HOME >> BIOLOGY >> NEWS
Folic Acid Lowers Risk Of Cardiovascular Disease

ANN ARBOR---University of Michigan scientists have solved the mystery behind folic acid's ability to reduce amounts of a compound called homocysteine, which is associated with an increased risk of heart attacks, strokes and birth defects in humans.

A team of U-M researchers led by Rowena G. Matthews, Ph.D., and Martha L. Ludwig, Ph.D., discovered the chemical and structural basis for folic acid's effectiveness while conducting research on an enzyme called methylenetetrahydrofolate reductase (MTHFR). This enzyme with the tongue-twisting name catalyzes a critical step in the biochemical chain reaction within cells that converts homocysteine to an essential amino acid called methionine. The U-M study is being published in the April 1 issue of Nature Structural Biology.

"This work illustrates why basic scientific research is so important," said Matthews, the G. Robert Greenberg Distinguished University Professor of Biological Chemistry and chair of the U-M's Biophysics Research Division. "Our original goal was simply to learn more about the biochemistry of MTHFR. We had no prior indication of any specific health-related application for our work, nor did we imagine that this enzyme would prove to be so important for human health.

"Much of the credit should go to the National Institute of General Medical Sciences of the National Institutes of Health," Matthews added, "because they continue to provide funding for this type of untargeted basic research."

Since the 1970s, researchers have known that administration of folic acid dramatically protects against the development of birth defects like spina bifida in humans. More recent evidence has suggested a correlation between high levels of homocysteine in blood and an increased risk of cardiovascular disease or spina bifida. In the mid-1990s, scientists discovered that increased folic acid intake reduced homocysteine. But no one understood how folic acid exerted its effect until the U-M study.


'"/>

Contact: Sally Pobojewski
pobo@umich.edu
734-647-1844
University of Michigan
1-Apr-1999


Page: 1 2 3

Related biology news :

1. Folic acid vitamin use by women reaches all-time high, March of Dimes survey finds
2. Folic acid may have no immediate impact on Down Syndrome
3. Folic acid-iron supplements reduce risk of low birth weight
4. Folic acid supplements not linked to multiple births
5. Folic acid supplements and fortified breakfast cereals can reduce homocysteine levels and ischemic heart disease risk
6. American Heart Association Comment: The Effect Of Folic Acid Fortification On Plasma Folate And Total Homocysteine Concentrations
7. Americans Urged To Consume More Folic Acid
8. New Analytical Methods Indicate Higher Folic Acid Concentration In Beans And Peas
9. Folic Acid Fortification Effective In Cereal Grains
10. Wake Forest Study Shows Soy Containing A Key Ingredient Is What Lowers Cholesterol
11. Stress Lowers Sperm Count By Overwhelming Cells That Make Testosterone

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... PUNE, India , April 13, 2017 According ... Identity Proofing, Identity Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication ... by MarketsandMarkets™, the IAM Market is expected to grow from USD 14.30 ... Annual Growth Rate (CAGR) of 17.3%. ... ...
(Date:4/6/2017)... April 6, 2017 Forecasts by ... Document Readers, by End-Use (Transportation & Logistics, Government & ... Gas & Fossil Generation Facility, Nuclear Power), Industrial, Retail, ... Are you looking for a definitive report ... ...
(Date:4/3/2017)... , April 3, 2017  Data captured ... engineering platform, detected a statistically significant association ... prior to treatment and objective response of ... potential to predict whether cancer patients will ... treatment, as well as to improve both pre-infusion ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... , ... ComplianceOnline’s Medical Device Summit is back for its 4th year. The ... Francisco, CA. The Summit brings together current and former FDA office bearers, regulators, industry ... officials from around the world to address key issues in device compliance, quality and ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are the main ... people each year. Especially those living in larger cities are affected by air pollution ... of the most pollution-affected countries globally - decided to take action. , “I knew ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that ... Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s Hospital Los ...
(Date:10/10/2017)... CRUZ, Calif. , Oct. 10, 2017 ... grant from the NIH to develop RealSeq®-SC (Single Cell), ... kit for profiling small RNAs (including microRNAs) from single ... Analysis Program highlights the need to accelerate development of ... "New techniques for measuring ...
Breaking Biology Technology:
Cached News: