HOME >> BIOLOGY >> NEWS
Forgetting, reminding, and remembering: The retrieval of lost spatial memory

Most forms of memory loss are caused by some type of brain injury -- particularly to the hippocampus. Amnesia can arise from brain damage that interferes with memory storage, retrieval, or consolidation. What ultimately causes amnesia -- a failure to store memories or a failure to retrieve them -- is not clear.

A major challenge in resolving this question experimentally is being able to determine whether an animal has truly recovered a lost memory or has simply re-learned the task at hand. By refining a classic behavioral neuroscience experiment to test spatial learning and memory, Livia de Hoz, Stephen Martin, and Richard Morris have developed a novel protocol that distinguishes retrieval from new learning. The original protocol, developed by Morris over fifteen years ago, takes advantage of the fact that rats are good swimmers but prefer life out of water. Rats are placed in an opaque pool and trained to remember the location of an escape platform, hidden just under the surface.

The new twist on the protocol gives rats a reminder by briefly raising the platform above the water in either the learned location or in a new 'false' location. If raising the platform was facilitating relearning, then animals capable of learning would look for the platform in the new location. But if raising the platform functioned as a reminder, then animals should gravitate toward the place they were trained to, regardless of whether the platform reminder was in the original location or a new one. And that's what happened to the rats with partial lesions.

Testing rats with partial damage to the hippocampus, they showed that the resulting memory impairment was not a result of storage failure, since the rats responded to the reminder treatment by recalling the original platform location. This argues strongly that at least part of the amnesia associated with hippocampal damage is a failure of retrieval. Teasing apart this story fully will require more experime
'"/>

Contact: Paul Ocampo
pocampo@plos.org
1-415-624-1224
Public Library of Science
16-Aug-2004


Page: 1 2

Related biology news :

1. Researchers concerned over early egg retrieval after cancer treatment - doctors advised to monitor pregnancies as mice study reveals problems
2. Study explains spatial orientation differences between sexes
3. Could memory performance and spatial learning be genetically based?
4. Brown research reveals key insight into memory-making
5. Wrapping a memory with an experience, capacity for recollection detected in non-human species
6. Mutant mice lead to memory insights
7. Protein believed to control formation of memory identified by Scripps & UCSD scientists
8. Alzheimers may leave some forms of memory intact
9. Study in flies allows researchers to visualize formation of a memory
10. Brain signal predicts working memory prowess
11. Lack of specific brain protein causes marked deficits in learning, memory

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/30/2017)... Today, American Trucking Associations announced Seeing ... and eye tracking software, became the newest member ... "Artificial intelligence and advanced sensing algorithms ... driver,s attentiveness levels while on the road.  Drivers ... fatigue and prevent potential accidents, which could lead ...
(Date:5/16/2017)... 16, 2017  Veratad Technologies, LLC ( www.veratad.com ), ... and identity verification solutions, announced today they will participate ... May 15 thru May 17, 2017, in ... Trade Center. Identity impacts the lives ... today,s quickly evolving digital world, defining identity is critical ...
(Date:4/19/2017)... 19, 2017 The global military ... is marked by the presence of several large global ... by five major players - 3M Cogent, NEC Corporation, ... for nearly 61% of the global military biometric market ... the global military biometrics market boast global presence, which ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... , ... October 11, 2017 , ... Personal eye wash is a basic first aid ... at a time. So which eye do you rinse first if a dangerous substance enters ... Plum Duo Eye Wash with its unique dual eye piece. , “Whether its dirt ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are ... 5.5 million people each year. Especially those living in larger cities are affected by ... in one of the most pollution-affected countries globally - decided to take action. , ...
(Date:10/10/2017)... ... October 10, 2017 , ... For the second time in ... STEM Mentoring Award. Representatives of the FirstHand program travelled to Washington, D.C. Tuesday, ... , US2020’s mission is to change the trajectory of STEM education in America ...
(Date:10/10/2017)... ... October 10, 2017 , ... The Pittcon Program Committee ... honoring scientists who have made outstanding contributions to analytical chemistry and applied ... the world’s leading conference and exposition for laboratory science, which will be held ...
Breaking Biology Technology:
Cached News: