HOME >> BIOLOGY >> NEWS
Forgetting, reminding, and remembering: The retrieval of lost spatial memory

Most forms of memory loss are caused by some type of brain injury -- particularly to the hippocampus. Amnesia can arise from brain damage that interferes with memory storage, retrieval, or consolidation. What ultimately causes amnesia -- a failure to store memories or a failure to retrieve them -- is not clear.

A major challenge in resolving this question experimentally is being able to determine whether an animal has truly recovered a lost memory or has simply re-learned the task at hand. By refining a classic behavioral neuroscience experiment to test spatial learning and memory, Livia de Hoz, Stephen Martin, and Richard Morris have developed a novel protocol that distinguishes retrieval from new learning. The original protocol, developed by Morris over fifteen years ago, takes advantage of the fact that rats are good swimmers but prefer life out of water. Rats are placed in an opaque pool and trained to remember the location of an escape platform, hidden just under the surface.

The new twist on the protocol gives rats a reminder by briefly raising the platform above the water in either the learned location or in a new 'false' location. If raising the platform was facilitating relearning, then animals capable of learning would look for the platform in the new location. But if raising the platform functioned as a reminder, then animals should gravitate toward the place they were trained to, regardless of whether the platform reminder was in the original location or a new one. And that's what happened to the rats with partial lesions.

Testing rats with partial damage to the hippocampus, they showed that the resulting memory impairment was not a result of storage failure, since the rats responded to the reminder treatment by recalling the original platform location. This argues strongly that at least part of the amnesia associated with hippocampal damage is a failure of retrieval. Teasing apart this story fully will require more experime
'"/>

Contact: Paul Ocampo
pocampo@plos.org
1-415-624-1224
Public Library of Science
16-Aug-2004


Page: 1 2

Related biology news :

1. Researchers concerned over early egg retrieval after cancer treatment - doctors advised to monitor pregnancies as mice study reveals problems
2. Study explains spatial orientation differences between sexes
3. Could memory performance and spatial learning be genetically based?
4. Brown research reveals key insight into memory-making
5. Wrapping a memory with an experience, capacity for recollection detected in non-human species
6. Mutant mice lead to memory insights
7. Protein believed to control formation of memory identified by Scripps & UCSD scientists
8. Alzheimers may leave some forms of memory intact
9. Study in flies allows researchers to visualize formation of a memory
10. Brain signal predicts working memory prowess
11. Lack of specific brain protein causes marked deficits in learning, memory

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
Breaking Biology Technology:
Cached News: