HOME >> BIOLOGY >> NEWS
Fosrenol (TM) reduces damaging high levels of phosphate in end-stage kidney disease patients

Philadelphia, Pa., USA Shire Pharmaceuticals Group plc (NASDAQ: SHPGY, LSE: SHP.L, TSE: SHQ CN) announces that long-term (two year) treatment with FOSRENOL™ (lanthanum carbonate) reduces damaging high phosphate levels, which most end-stage renal disease (ESRD) patients experience, according to data from two studies presented at the American Society of Nephrology (ASN) 35th Annual Meeting.

According to the two trials, lanthanum carbonate is well tolerated and associated with the reduced occurrence of high calcium levels, a side effect of some current therapies that has been linked to increased calcification of the coronary arteries in the heart.

Shire has submitted lanthanum carbonate under the trade name of FOSRENOL for regulatory review in the United States, European Union and Canada. The product is under development in Japan.

"Data from the two trials illustrate that lanthanum carbonate has the potential to reduce dangerously high phosphate levels safely and effectively. Previous data from a separate phase 3 long-term safety study indicate that there is no demonstrable link between lanthanum administration and bone toxicity. These data suggest that lanthanum carbonate will deliver tangible clinical benefits to dialysis patients," says William F. Finn, M.D., professor of medicine at the University of North Carolina School of Medicine at Chapel Hill, regarding his interim analysis of 1,203 ESRD dialysis patients enrolled in a two-year trial at 96 U.S. sites, presented at the ASN meeting.

Studies show lanthanum carbonate has a good safety and efficacy profile in the treatment of hyperphosphatemia in dialysis patients

Finn's study [ASN Poster SA-P0600] showed that after one year of therapy, patients receiving lanthanum carbonate had similar reductions in average phosphorus levels compared to those on standard therapies, including aluminum salts, calcium salts or sevelamer. The study also showed that patients in the
'"/>

Contact: Michele Roy , Shire
450-978-7938
Porter Novelli
2-Nov-2002


Page: 1 2 3 4

Related biology news :

1. Pneumococcal vaccine reduces ear infections, pneumonia, new study shows
2. Preschool bolsters early childhood immunity, reduces risk of young adult Hodgkins lymphoma
3. Structure solved at Scripps shows how one human protein reduces potency of chemotherapy
4. Underground carbon dioxide storage reduces emissions
5. Gene therapy reduces drinking in rats with genetic predisposition to alcoholism
6. Exercise reduces blood estrogens, risk for breast cancer in post menopausal women
7. Biosensor-regulated gene therapy reduces heart attack damage in mice
8. Study examines whether giving good bacteria reduces infections
9. Mastectomy dramatically reduces breast cancer risk among women with BRCA1/2 mutations
10. Dec. 17 JAMA study shows new biologic drug reduces psoriasis symptoms, improves quality of life
11. Water treatment reduces risk of Legionnaires

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/22/2018)... , ... December 21, 2018 , ... ... sponsored and hosted the Boston Healthcare Drinks event featuring Helen Chen, Greater China ... from China.” , The discussion was moderated by patent attorney David J. ...
(Date:12/19/2018)... ... 2018 , ... NDA Partners Chairman Carl Peck, MD, announced today that ... for Devices and Radiological Health (CDRH), has been appointed a Partner in the firm. ... she has more than 25 years of regulatory experience. In addition to her FDA ...
(Date:12/19/2018)... ... December 19, 2018 , ... OrthoSpace Ltd. (“OrthoSpace” or “the ... evaluating the use of novel surgical techniques, including the OrthoSpace InSpace™ balloon spacer, ... disabling condition for which there are historically few treatment options. The present study ...
Breaking Biology News(10 mins):
(Date:1/20/2019)... ... January 17, 2019 , ... TrakCel, the leading cell and ... Life Science Group (Quick Healthcare and QuickSTAT) today announce a partnership to offer ... and gene therapy industry to track products and manage the logistical processes of ...
(Date:1/15/2019)... ... 15, 2019 , ... With the U.S. Congress designating January as Cervical Health Awareness Month ... today announces tips to help reduce the risk of Cervical Cancer. , Cervical cancer ... is the #1 most common STD and an STI that almost half of ...
(Date:1/11/2019)... TORONTO (PRWEB) , ... January 11, 2019 , ... Drawing ... place on Tuesday, January 22, 2019 at 2:30pm EST will explore some of the ... and benefits of using one vendor vs. using multiple vendors, and find out how ...
(Date:1/10/2019)... (PRWEB) , ... January 08, ... ... Implant Co, (SAGICO), an innovative spinal implant company, announced today that SAGICO ... San Francisco, California. The annual J.P. Morgan Healthcare Conference is the ...
Breaking Biology Technology:
Cached News: