HOME >> BIOLOGY >> NEWS
Fox Chase Cancer Center research reveals how COX-2 causes ovarian cancer

Fox Chase Cancer Center scientists have identified how an enzyme called COX-2 may promote the development of ovarian tumors, adding further insight into the mechanism of COX-2 inhibitors and the prevention of this highly lethal disease. The data was presented today at the 95th Annual Meeting of the American Association for Cancer Research in Orlando, Fla.

"We have found that the over-expression of COX-2 correlates with the loss of the basement membrane in ovarian epithelium cells, thus promoting cancer," said Mike (Xiang-Xi) Xu, Ph.D., who heads the Fox Chase team in this research. "A COX-2 inhibitor may reduce the loss of basement membrane and thus decrease cancer risk."

Previous research had shown that COX-2 inhibitors such as aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) slow the growth of tumors, particularly of the breast and colon, but only now are researchers beginning to understand how COX-2 inhibitors work in thwarting cancer.

In the ovaries and other tissues, basement membrane provides a scaffold to which cells called epithelial cells adhere in an organized fashion, Xu explained. When there is no basement membrane, the epithelial cells become disorganized and unregulated and may undergo transformation from a normal to cancerous state. Xu added that basement membrane is also lost during ovulation, which may help explain the association between frequent ovulation and higher ovarian cancer risk.

Ovarian cancer claims the lives of over 14,000 women each year in the United States, making it the most lethal of all gynecologic malignancies. A strong family history of ovarian or breast cancer is evident in about 5 to 10 percent of ovarian cancer cases. While an average woman's risk of getting ovarian cancer is only about 1.4 percent over her lifetime, the risk increases to between 15 and 60 percent if two or more first-degree relatives (parents, siblings or children) have developed ovarian, breast or a certain type of b
'"/>

Contact: Karen Carter Mallet
karen.carter@fccc.edu
215-728-2700
Fox Chase Cancer Center
28-Mar-2004


Page: 1 2 3

Related biology news :

1. Fox Chase Cancer Centers Alfred Knudson Jr. named 2004 Kyoto Prize winner
2. Fox Chase discovery may help physicians diagnose, treat devastating childhood disease
3. Wilex & Fox Chase Cancer Center begin trial w/ novel compound targeting tumor invasion & metastasis
4. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
5. Fox Chase Cancer Center researchers identify significant smoking-induced genetic alteration
6. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
7. Fox Chase Cancer Center researcher develops new model for studying prions mad cow disease
8. Fox Chase Cancer Center study: Novel DNA-repair gene mutation can cause resistance to cancer drugs
9. NIH funds Breast Cancer and the Environmental Research Center at Fox Chase Cancer Center
10. Fox Chase Cancer Center researchers make significant discovery about function of p53
11. Fox Chase Cancer Center receives grant to study possible link between measles vaccine and autism

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/4/2019)... , ... June 04, 2019 , ... ... of orthopedic medical devices, today announced Q1-19 revenues of $31M, up 12% from ... with successful roll-out of strategic investments & operational excellence initiatives worldwide. , ...
(Date:6/4/2019)... ... ... Lajollacooks4u is delighted to announce it has been named as one of ... only to businesses that have achieved consistently outstanding traveler reviews on TripAdvisor, as well ... qualify for the Certificate of Excellence –- an award that only 10 percent of ...
(Date:5/31/2019)... , ... May 30, 2019 , ... ... testing company, and Mayo Clinic, have documented significant differences in the prevalence of ... and ethnic populations compared to non-Hispanic White women. Results will be presented at ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... ... May 30, 2019 , ... A study ... efficient delivery system for the sustained release of human placental stem cell (HPSC)-derived ... was able to deliver CM into the injured kidney, where it helped restore ...
(Date:5/15/2019)... ... 15, 2019 , ... Milton Hershey School® has named William Charles Ballough Harding ... biomedical industry, where he is changing lives by creating solutions to global healthcare challenges ... the vision of our founders – Milton and Catherine Hershey – who always hoped ...
(Date:5/14/2019)... LA JOLLA, Calif. (PRWEB) , ... May 14, 2019 , ... ... announces an office expansion, effectively doubling its space from 2,500 to 5,000 square feet. ... SneakPeek Early Gender DNA tests ,” says Gateway Genomics CEO, Chris Jacob. “The ...
(Date:5/4/2019)... Brazil (PRWEB) , ... May 03, 2019 , ... ... given by the President of the Dakila Pesquisas Association, the scientist and ufologist ... Councilmen 2019, in Brasília (DF). Urandir detailed the results of some research carried ...
Breaking Biology Technology:
Cached News: