HOME >> BIOLOGY >> NEWS
Fox Chase Cancer Center research reveals how COX-2 causes ovarian cancer

owel cancer.

The important role of inheritance has led many women with a family history of breast or ovarian cancer to have their breasts and ovaries removed as a means of preventing the development of cancer. Xu and his colleagues studied the tissues removed during prophylactic oophorectomy (removal of the ovaries) for clues about the precancerous changes that go on in the cells.

One of the cell proteins they analyzed was COX-2, a physiologically important enzyme that plays a role in ovulation as well as in antibacterial, immunologic and inflammatory processes. COX-2 has also been shown to stimulate tumor cell division and angiogenesis (new blood vessel formation) and to inhibit a type of programmed cell death called apoptosis, which helps control the growth of tumors. Xu's analysis of the ovarian tissue specimens showed that as the level of COX-2 increases, it appears to promote the loss of basement membrane.

Treatment with COX-2 inhibitors may prevent the development of cancer cells. In fact, the National Cancer Institute will launch a human clinical trial of COX-2 inhibitors. Mary B. Daly, M.D., Ph.D., director of Fox Chase's Cancer Control Program, is heading the multi-center trial, which will include Fox Chase as one of its sites. Fox Chase has one of four Specialized Programs of Research Excellence (SPORE) in Ovarian Cancer, established by the NCI in 1999.

Understanding what happens in ovarian cells before they become cancerous is important not only because it may lead to preventive therapies but also because it may lead to the identification of markers of the disease that will be useful for diagnosis and for assessing treatment results. One of the reasons for the high death rate among women who develop ovarian cancer is that diagnosis often is delayed until late stages of the disease.

In addition to Xu and Daly, the Fox Chase research team includes Isabelle H. Roland, Wan-Lin Yang, Ph.D., Dong-Hua Yang, M.D., Ph.D., Robert F.
'"/>

Contact: Karen Carter Mallet
karen.carter@fccc.edu
215-728-2700
Fox Chase Cancer Center
28-Mar-2004


Page: 1 2 3

Related biology news :

1. Fox Chase Cancer Centers Alfred Knudson Jr. named 2004 Kyoto Prize winner
2. Fox Chase discovery may help physicians diagnose, treat devastating childhood disease
3. Wilex & Fox Chase Cancer Center begin trial w/ novel compound targeting tumor invasion & metastasis
4. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
5. Fox Chase Cancer Center researchers identify significant smoking-induced genetic alteration
6. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
7. Fox Chase Cancer Center researcher develops new model for studying prions mad cow disease
8. Fox Chase Cancer Center study: Novel DNA-repair gene mutation can cause resistance to cancer drugs
9. NIH funds Breast Cancer and the Environmental Research Center at Fox Chase Cancer Center
10. Fox Chase Cancer Center researchers make significant discovery about function of p53
11. Fox Chase Cancer Center receives grant to study possible link between measles vaccine and autism

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/13/2019)... ... 2019 , ... KICVentures announced today its plans to host an ... Management-Driven ASC Conference in Chicago on Thursday, June 13th at 6:30 pm. The event ... in the 3rd floor Ticino Hospitality room in space #74T. , The event will ...
(Date:6/6/2019)... ... 05, 2019 , ... Pelican BioThermal , the global ... service center in Mexico City, Mexico. Mexico is the second largest pharmaceutical market ... $1.75 billion in pharmaceutical exports since 2015. The Mexico City network station will ...
(Date:6/4/2019)... ... June 04, 2019 , ... Most preclinical EEG ... seizure risk signals, usually based on variations of amplitude, frequency or spike train ... diagnostic methodology due to the complexity and variability of the signal, and automation ...
Breaking Biology News(10 mins):
(Date:7/9/2019)... Ky. (PRWEB) , ... July 08, 2019 , ... ... Award winner. The company’s SmartLight Indicator was recognized as the 2019 Innovative Product ... sensors industry forward. The prestigious awards were during Sensors Expo & Conference ...
(Date:6/12/2019)... TOWNSHIP, N.J. (PRWEB) , ... June 12, 2019 ... ... of custom built, helium-based leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device ... with Shanghai Zillion has been signed. The agreement will grant exclusive rights for ...
(Date:6/11/2019)... Calif. (PRWEB) , ... June 11, 2019 , ... ... company of Personalized Stem Cells Inc. (PSC) , has announced that their ... Public Health, Food and Drug Branch for manufacturing. This is an important ...
(Date:5/31/2019)... ... 30, 2019 , ... World Compliance Seminars today announced a ... in Boston, MA. This peer recommended interactive workshop is always selected by professionals ... kick off with a compendial treatment of Data Integrity fundamentals. After laying the ...
Breaking Biology Technology:
Cached News: