HOME >> BIOLOGY >> NEWS
Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine

Fox Chase Cancer Center researchers have demonstrated the ability to identify kidney cancer, including localized (stage I) cancer, in the urine of affected patients. What's more, urine tests were repeated following the removal of the cancerous kidney and none of the tests showed DNA evidence of disease. These research findings were presented at the American Urological Association Annual Meeting May 8-13, 2004 in San Francisco.

As with other cancers, an early diagnosis of kidney cancer can result in curative treatment whereas the prognosis for advanced kidney cancer is poor. The challenge in diagnosing cancer early is developing an inexpensive, noninvasive, accurate and simple screening test. A urine test meets these standards.

"We used a common laboratory procedure to test the urine of 50 patients with kidney cancer," explained Fox Chase molecular biologist Paul Cairns, Ph.D. "Forty-four of the 50 tests showed gene changes in the urine that were identical to the gene changes found in the tumor tissue taken at the time of surgery."

When the same test was conducted on the controls urine from people without cancer none showed the relevant gene alterations that were found in the urine from people with cancer.

"The test appears to be remarkably accurate with no false-positives in this study," said Robert G. Uzzo, M.D., a urologic surgeon at Fox Chase and lead author of the abstract. "In addition, one of the most impressive outcomes of this research is that the test also identified 27 of the 30 patients with stage I disease."

The researchers then tested the urine of 17 patients after they had surgery to remove the cancerous kidney. Mutated genes present in the urine prior to the kidney removal were not present in the urine after the kidney was removed.

"This step in our research further supports the accuracy of this potential screening test but also demonstrates the possibility of using urine to monitor the
'"/>

Contact: Karen C. Mallet
k_carter@fccc.edu
215-728-2700
Fox Chase Cancer Center
9-May-2004


Page: 1 2

Related biology news :

1. Fox Chase Cancer Centers Alfred Knudson Jr. named 2004 Kyoto Prize winner
2. Fox Chase discovery may help physicians diagnose, treat devastating childhood disease
3. Wilex & Fox Chase Cancer Center begin trial w/ novel compound targeting tumor invasion & metastasis
4. Fox Chase Cancer Center researchers identify significant smoking-induced genetic alteration
5. Fox Chase Cancer Center research reveals how COX-2 causes ovarian cancer
6. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
7. Fox Chase Cancer Center researcher develops new model for studying prions mad cow disease
8. Fox Chase Cancer Center study: Novel DNA-repair gene mutation can cause resistance to cancer drugs
9. NIH funds Breast Cancer and the Environmental Research Center at Fox Chase Cancer Center
10. Fox Chase Cancer Center researchers make significant discovery about function of p53
11. Fox Chase Cancer Center receives grant to study possible link between measles vaccine and autism

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... August 25, 2020 , ... ... in partnership with Essex Bio-Technology, a bio-pharmaceutical company specializing in Ophthalmology and ... study of SkQ1 ophthalmic solution in patients with moderate to severe Dry ...
(Date:8/21/2020)... ... August 18, 2020 , ... Sentien Biotechnologies, Inc., ... the U.S. Food and Drug Administration (FDA) has approved the company’s Investigational New ... treatment of severe COVID-19. Approval of this IND allows Sentien to initiate a ...
(Date:8/12/2020)... ... August 11, 2020 , ... ... in Princeton, NJ, have entered into license agreements with Housey Pharma’s HMI subsidiary ... Both Roche and J&J have annual Research and Development spending in excess of ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... 2020 , ... The SDX® Respiratory Gating System , ... reached its 20th anniversary of worldwide use. Introduced in the US over the ... University of Pennsylvania, University of Michigan, University of Maryland, University of California San ...
(Date:7/18/2020)... (PRWEB) , ... July 16, 2020 , ... “We are ... Third Wave Bioactives. “It’s the only technology of its kind on the market and ... of onions with the protective capacity of traditional cultured ingredients, creating a natural way ...
(Date:7/10/2020)... , ... July 09, 2020 ... ... company, announced today that Massachusetts Institute of Technology (MIT) has expanded the ... license allows PathSensors to move into the point-of-care diagnostic market, focusing initially ...
(Date:7/7/2020)... ... July 06, 2020 , ... Bio-IT World has ... Lilly, Bristol-Myers Squibb, the University of Chicago, Massachusetts General Hospital, Mission: Cure, and ... elite awards program, highlighting outstanding examples of how technology innovations and strategic initiatives ...
Breaking Biology Technology:
Cached News: