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Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine

patient after treatment," Uzzo added.

The researchers used a molecular DNA-based test called methylation-specific PCR (polymerase chain reaction) to detect gene alterations that initiate and fuel the onset of cancer. The test searched for six cancer specific tumor-suppressor genes that were altered causing them to falter in their critical role of preventing errant cell growth. These six genes are usually identified only after a pathologist's review of tumor tissue.

"In addition to early detection, differential diagnosis and surveillance, this testing could potentially be extended in the future to simultaneously provide molecular staging and prognostic information," Uzzo concluded.

Currently, kidney cancer is diagnosed after radiographic imaging of the kidney, which may include an ultrasound, CT scan and/or MRI. Biopsy of a kidney mass is often difficult to interpret or may give a false negative result and therefore currently confirmation of radiographic results is primarily after surgical excision. There is no protein marker test for kidney cancer as there is for prostate cancer with the PSA test.


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Contact: Karen C. Mallet
k_carter@fccc.edu
215-728-2700
Fox Chase Cancer Center
9-May-2004


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