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Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine

PHILADELPHIA Laboratory researchers and urologic oncologists from Fox Chase Cancer Center have demonstrated the ability to identify kidney cancer, including localized (stage I) cancer, in the urine of affected patients. The research, supported in part by a grant from the Flight Attendants Medical Research Institute and the National Cancer Institute's Early Detection Research Network, is published in the Dec. 15 issue of the journal Cancer Research.

As with other cancers, an early diagnosis of kidney cancer can result in curative treatment whereas the prognosis for advanced kidney cancer is poor. The challenge in diagnosing cancer early is developing an inexpensive, noninvasive, accurate and simple screening test.

The researchers say a urine test meets these standards. Currently, kidney cancer is diagnosed after radiographic imaging of the kidney, which may include an ultrasound, CT scan and/or MRI. Biopsy of a kidney mass is often difficult to interpret or may give a false negative result and therefore currently confirmation of radiographic results is primarily after surgical excision. There is no protein marker test for kidney cancer as there is for prostate cancer with the PSA test.

"We used a common laboratory procedure to test the urine of 50 patients with kidney cancer," explained Fox Chase molecular biologist Paul Cairns, Ph.D., lead author of the study. "Forty-four of the 50 tests showed gene changes in the urine that were identical to the gene changes found in the tumor samples taken at the time of surgery."

When the same test was conducted on the controls urine from people without cancer none showed the relevant gene alterations that were found in the urine from people with cancer.

"The test is remarkably accurate with no false-positives in this study," said Robert G. Uzzo, M.D., a urologic surgeon at Fox Chase and co-author of the paper. "In addition, one of the most impressive outcomes of this research is that t
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Contact: Karen Carter Mallet
k_carter@fccc.edu
215-728-2700
Fox Chase Cancer Center
15-Dec-2003


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