HOME >> BIOLOGY >> NEWS
Fox Chase Cancer Center researcher develops new model for studying prions mad cow disease

PHILADELPHIA--Fox Chase Cancer Center researchers and their colleagues in Japan and San Francisco have obtained new insight into the molecular structure of prion particles responsible for mad cow disease and other degenerative neurological disorders. In new research to be published in this week's Online Early Edition of the Proceedings of the National Academy of Sciences (www.pnas.org), Fox Chase biophysicist Heinrich Roder, Ph.D., and colleagues describe a computer model of the structural core of prions, based on biophysical measurements of a fibrous form of a prion protein fragment. Prions are infectious protein particles linked to degenerative neurological diseases in animals and humans, such as mad cow disease (bovine spongiform encephalopathy or BSE) in cattle, scrapie in sheep and goats, and Creutzfeldt-Jakob disease (CJD) in humans.

For proteins, form really does equal function. Not only are they essential building blocks of the body, but proteins are also the workers of every cell, carrying out its specific functions. This function depends on the ultimate three-dimensional shape of the protein, a form achieved by folding flexible chains of amino acids until each is properly aligned so that the protein can do its job. Normally, the folding of proteins is highly efficient and specific, but sometimes the process goes awry, resulting in dangerous misfolded forms.

Prion diseases result from the conversion of a normal cellular protein into an alternative structure that forms threadlike fibers called amyloid fibrils. They accumulate in target tissues, such as brain tissue, where they cause the progressive degeneration of cognitive and motor functions and ultimately prove fatal.

Amyloid fibrils form as a result of mistakes in a protein's normal folding process. Each disease involving amyloid fibrils stems from the misfolding of a different protein that then packs into a similar structure. The formation of amyl
'"/>

Contact: Karen Carter Mallet
k_carter@fccc.edu
215-728-2700
Fox Chase Cancer Center
2-Dec-2003


Page: 1 2 3

Related biology news :

1. Fox Chase Cancer Centers Alfred Knudson Jr. named 2004 Kyoto Prize winner
2. Fox Chase discovery may help physicians diagnose, treat devastating childhood disease
3. Wilex & Fox Chase Cancer Center begin trial w/ novel compound targeting tumor invasion & metastasis
4. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
5. Fox Chase Cancer Center researchers identify significant smoking-induced genetic alteration
6. Fox Chase Cancer Center research reveals how COX-2 causes ovarian cancer
7. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
8. Fox Chase Cancer Center study: Novel DNA-repair gene mutation can cause resistance to cancer drugs
9. NIH funds Breast Cancer and the Environmental Research Center at Fox Chase Cancer Center
10. Fox Chase Cancer Center researchers make significant discovery about function of p53
11. Fox Chase Cancer Center receives grant to study possible link between measles vaccine and autism

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/25/2019)... , ... September 25, 2019 , ... ... leaders through off-the-record collaboration and dialogue, today announces its inaugural South CEO ... BioInnovation Center in Louisiana. , Co-produced by Tulane University, this invitation-only meeting ...
(Date:9/24/2019)... , ... September 24, 2019 , ... ... characterize protein interactions for accelerated drug development, announced today that it has raised ... led by OS Fund and also includes AME Cloud Ventures, Boom Capital, Madrona ...
(Date:9/17/2019)... ... September 17, 2019 , ... Last week, Blackrock Microsystems, ... from the Medical University of Warsaw, met at the Presidential Palace of the ... a neuroprosthetic system as part of an initiative called "Startups in the Palace ...
Breaking Biology News(10 mins):
(Date:9/24/2019)... (PRWEB) , ... September 24, ... ... be presenting their latest research in the area of high-level X-ray methods ... Dr. Pamela Smith, COO of Improved Pharma, will present “Synchrotron X-Ray Diffraction ...
(Date:9/24/2019)... S.D. (PRWEB) , ... September 24, 2019 , ... In ... funding for research led by faculty at South Dakota School of Mines & ... the tiny microbes that attach to surfaces to form a slimy and yet strong ...
(Date:9/17/2019)... ... , ... Jennifer Hermansky and Fang Xie, Ph.D. , attorneys ... 2019 Rising Stars. Hermansky and Xie, named an Immigration Rising Star and a Life ... practice areas. The list highlights attorneys “whose legal accomplishments transcend their age,” according to ...
(Date:9/11/2019)... ... 2019 , ... Suvoda LLC , a SaaS provider ... management, today announced its new technology partnership with Veeva Systems , a ... Veeva Vault EDC and our IRT will enable sponsors and CROs to run ...
Breaking Biology Technology:
Cached News: