HOME >> BIOLOGY >> NEWS
Fox Chase Cancer Center researcher publishes new findings on the developmental origin of liver and pancreas

PHILADELPHIA (February 27, 2001) -Research conducted at Fox Chase Cancer Center shows that cells which develop into the liver can also give rise to part of the pancreas, according to a new study published in the March issue of Development, Volume 128(6). The finding counters the assumption that during the early stages of mammalian development, the liver and pancreas cells develop from separate lineages.

Kenneth S. Zaret, Ph.D. and his research team had originally been studying the development of the liver in mouse embryos, and then discovered that the ventral part of the pancreas develops at the same time as the liver and from the same general domain of endoderm cells.

Different domains of the endoderm, an early embryonic tissue, normally differentiate into liver, lung, pancreas, thyroid, and intestine; yet how these diverse tissue domains are specified, and whether each tissue domain can give rise to other tissue derivatives, has been unclear. Differentiation is the process whereby embryonic cells become specialized in structure and function, and organize into the tissues and organs that make up the adult organism.

The goal of this research was to understand basic principles by which different cell types arise from a common cell population.

Dr. Zaret's group hypothesized that early embryonic cells that normally become the liver may also have the capacity to become the ventral part of the pancreas. They previously developed techniques for isolating cells from the ventral endoderm of a mouse embryo and for culturing the cells in the laboratory, allowing the researchers to closely follow the generation of the liver or pancreatic cell lineages.

Earlier, they used this culture method to show that fibroblast growth factor (FGF), a signal secreted from embryonic heart tissue, would cause nearby ventral endoderm cells to initiate liver development.

The embryonic liver normally originates next to the cardiac domain. In the present study, D
'"/>

Contact: Anjou K. Dargar
a_dargar@fccc.edu
215-728-7784
Fox Chase Cancer Center
26-Feb-2001


Page: 1 2

Related biology news :

1. Fox Chase Cancer Centers Alfred Knudson Jr. named 2004 Kyoto Prize winner
2. Fox Chase discovery may help physicians diagnose, treat devastating childhood disease
3. Wilex & Fox Chase Cancer Center begin trial w/ novel compound targeting tumor invasion & metastasis
4. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
5. Fox Chase Cancer Center researchers identify significant smoking-induced genetic alteration
6. Fox Chase Cancer Center research reveals how COX-2 causes ovarian cancer
7. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
8. Fox Chase Cancer Center researcher develops new model for studying prions mad cow disease
9. Fox Chase Cancer Center study: Novel DNA-repair gene mutation can cause resistance to cancer drugs
10. NIH funds Breast Cancer and the Environmental Research Center at Fox Chase Cancer Center
11. Fox Chase Cancer Center researchers make significant discovery about function of p53

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/14/2019)... ... May 13, 2019 , ... BioMedGPS is ... very special Pre-EWMA 2019 event at Gothenburg’s Universeum Aquarium. Guests will be treated ... Innovations in Advanced Wound Care. , SmartTRAK’s Advanced Wound Care Experts will serve ...
(Date:5/8/2019)... ... May 08, 2019 , ... ... that business professional Carol S. Mann has agreed to serve as Chief Executive ... and Chief Operating Officer, effective immediately. They will join Chairman and Founder Roger ...
(Date:5/7/2019)... ... May 07, 2019 , ... ... on-site Legionella DNA test in the UK. , In May, Landsec will undertake ... results in 45 minutes, enabling operators to take corrective action within hours instead ...
Breaking Biology News(10 mins):
(Date:4/16/2019)... ... April 16, 2019 , ... ... applications, and technology, today announced that Bank South Pacific (BSP), the largest regionally ... process. The bank awarded Fulcrum a contract to deliver a fingerprint-based Know Your ...
(Date:4/9/2019)... ... April 09, 2019 , ... ... on increasing the capacity of life sciences organizations to accelerate innovation and maximize ... platform in the past 12 months. , USDM’s Cloud Assurance ...
(Date:4/8/2019)... ... April 09, 2019 , ... ... non-profit research center Chan Zuckerberg Biohub (CZ Biohub) has chosen Geneious Biologics to ... is part of CZ Biohub’s efforts to establish new approaches to inform the ...
(Date:3/27/2019)... , ... March 27, 2019 , ... In honor of ... awareness on the importance of healthy meals and good nutrition. This month, Chef ... Food Bank’s volunteer chef. , The first segment addressed the nutritional value ...
Breaking Biology Technology:
Cached News: