HOME >> BIOLOGY >> NEWS
Fox Chase Cancer Center researchers identify significant smoking-induced genetic alteration

A Fox Chase Cancer Center researcher and her colleagues have identified a genetic alteration that occurs 13 times more frequently in lung tissue of mice exposed to tobacco smoke. The frequency of this genetic alteration and its role in estrogen metabolism could help researchers understand why women who smoke are more susceptible to lung cancer. These findings were presented today at the 95th Annual Meeting of the American Association for Cancer Research in Orlando, Fla.

The researchers found 53 smoking-induced genetic alterations in mice exposed to tobacco smoke compared to unexposed controls. The most notable finding was the 13-fold overexpression of the enzyme CYP1B1.

"Our research demonstrates that this alteration isn't present in the lung tissue prior to tobacco exposure," said Fox Chase researcher Sibele I. Meireles, Ph.D., lead author of the research. "Since we know this alteration is present in human lung tumors, it could be a target for chemopreventive intervention in people at high risk for lung cancer--in particular, active smokers."

Because CYP1B1 activates estradiol, one of the body's natural estrogen hormones, this finding could also help researchers understand more about why female smokers are more susceptible to lung cancer than male smokers.

"The overexpression of CYP1B1 poses an interesting question about gender differences in the development of lung cancer," said Meireles "We hadn't intended to look at gender differences in this study, but this finding about an enzyme so important to estrogen metabolism once again raises the issue of whether estrogen has a role in promoting lung cancer, as it does in breast and ovarian cancer."

The American Cancer Society estimates that 173,770 people will be diagnosed with lung cancer in 2004 and an estimated 160,440 people will die of the disease this year.

Meireles is a postdoctoral associate in the laboratory of cell biologist Margie L. Clapper, Ph.D., director of ch
'"/>

Contact: Karen Carter Mallet
karen.carter@fccc.edu
215-728-2700
Fox Chase Cancer Center
29-Mar-2004


Page: 1 2

Related biology news :

1. Fox Chase Cancer Centers Alfred Knudson Jr. named 2004 Kyoto Prize winner
2. Fox Chase discovery may help physicians diagnose, treat devastating childhood disease
3. Wilex & Fox Chase Cancer Center begin trial w/ novel compound targeting tumor invasion & metastasis
4. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
5. Fox Chase Cancer Center research reveals how COX-2 causes ovarian cancer
6. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
7. Fox Chase Cancer Center researcher develops new model for studying prions mad cow disease
8. Fox Chase Cancer Center study: Novel DNA-repair gene mutation can cause resistance to cancer drugs
9. NIH funds Breast Cancer and the Environmental Research Center at Fox Chase Cancer Center
10. Fox Chase Cancer Center researchers make significant discovery about function of p53
11. Fox Chase Cancer Center receives grant to study possible link between measles vaccine and autism

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/9/2019)... Del. (PRWEB) , ... July 08, 2019 , ... ... Court ruled in favor of Danisco’s ownership of the innovation behind two Danisco ... that an entitlement action could be based on prior art was without merit ...
(Date:6/27/2019)... ... June 27, 2019 , ... Lighting designers from integrated ... Society (IES), which honored the designers for creating both engaging and energy efficient lighting ... Street , an office tower in San Diego, California earned an IES Illumination Award ...
(Date:6/24/2019)... , ... June 24, 2019 , ... According to the ... one of the four most common STDs: chlamydia, gonorrhea, trichomoniasis (or "trich") and syphilis. ... that gay and bisexual African American men accounted for the largest number of HIV ...
Breaking Biology News(10 mins):
(Date:7/9/2019)... ... July 08, 2019 , ... Today, at the BIO World ... Corn Growers Association (NCGA) announced the winners of the Consider Corn Challenge II. ... process using field corn to produce biobased materials. , “Corn is a sustainable, ...
(Date:7/2/2019)... ... ... Leading Regenerative Veterinary Medicine company, VetStem Biopharma , was recently featured ... focuses on regenerative veterinary medicine as a means of improving the quality of life ... the Brentwood and Pacific Palisades International Film Festival in Los Angeles, California where it ...
(Date:6/18/2019)... , ... June 17, 2019 , ... ... they have entered into an agreement for production and manufacturing of GMP-grade adeno-associated ... treatment of rhodopsin-mediated autosomal dominant retinitis pigmentosa (RHO-adRP) and IC-200 for the treatment ...
(Date:6/12/2019)... TOWNSHIP, N.J. (PRWEB) , ... June 12, 2019 ... ... of custom built, helium-based leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device ... with Shanghai Zillion has been signed. The agreement will grant exclusive rights for ...
Breaking Biology Technology:
Cached News: