HOME >> BIOLOGY >> NEWS
Fox Chase Cancer Center researchers make significant discovery about function of p53

PHILADELPHIA (February 2, 2003) -- Cancer researchers have known that the tumor-suppressor gene p53 is critical in preventing cells from dividing inappropriately and becoming tumors. But now, researchers at Fox Chase Cancer Center have established that the ability of the p53 gene to perform its job depends on the type of p53 within each cell. This and another new finding about p53, published in Nature Genetics (Feb. 3, 2003 online version, March 2003 print version), have implications for tailoring chemotherapy, designing new cancer treatments, and understanding how to treat cancer in certain populations.

The existence of two variants, or polymorphisms, of p53 isnt new, but weve discovered that the variant type in each cell can influence its tumor-suppressor ability, explains senior author Maureen Murphy, Ph.D., a molecular biologist in the pharmacology department of Fox Chase Cancer Center, Philadelphia, Pa.

When functioning properly, p53 polices cells for problems such as errant cellular growth, the hallmark of human cancer. If such harmful factors are present, p53 triggers the process of programmed cell death (known as apoptosis)-in effect, causing the bad cells to self-destruct. Alterations, or mutations, in this gene have been found in more than 60 percent of human cancers.

Murphy and her colleagues have known about the two p53 variants, but how the differences affect p53s ability to suppress tumor development was not previously understood until now.

People have one form or another of p53, says Murphy. The p53 variant containing the amino acid called arginine is better at killing out-of-control cells. The other p53 variant with the amino acid proline is less capable of stopping errant cells. When we asked if the two forms might function differently, the answer was a resounding yes.

In terms of treating cancer, patients could potentially be typed for the kind of p53 they have, some day allowing physicians to tailor their therapy.
'"/>

Contact: Karen Mallet
k_carter@fccc.edu
215-728-2700
Fox Chase Cancer Center
2-Feb-2003


Page: 1 2 3

Related biology news :

1. Fox Chase Cancer Centers Alfred Knudson Jr. named 2004 Kyoto Prize winner
2. Fox Chase discovery may help physicians diagnose, treat devastating childhood disease
3. Wilex & Fox Chase Cancer Center begin trial w/ novel compound targeting tumor invasion & metastasis
4. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
5. Fox Chase Cancer Center researchers identify significant smoking-induced genetic alteration
6. Fox Chase Cancer Center research reveals how COX-2 causes ovarian cancer
7. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
8. Fox Chase Cancer Center researcher develops new model for studying prions mad cow disease
9. Fox Chase Cancer Center study: Novel DNA-repair gene mutation can cause resistance to cancer drugs
10. NIH funds Breast Cancer and the Environmental Research Center at Fox Chase Cancer Center
11. Fox Chase Cancer Center receives grant to study possible link between measles vaccine and autism

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... ... August 14, 2019 , ... Join Jonathan Riek, PhD, VP, ... on Tuesday, September 10, 2019 at 1pm EDT to learn about two common imaging ... , NAFLD is the most common diffuse liver disease, with a worldwide prevalence ...
(Date:8/9/2019)... ... ... With a demand in healthcare to lower unneeded emergency room visits and provide ... in the coming years, according to a new report on the industry by market ... is a detailed look at the current state of these healthcare outlets, including the ...
(Date:8/6/2019)... , ... August 06, 2019 , ... ... and environmental concerns. One plant-based food in particular quickly entered the limelight – ... product developers use a thermogelling and emulsifying ingredient such as methyl cellulose. This ...
Breaking Biology News(10 mins):
(Date:8/6/2019)... ... 06, 2019 , ... The San Diego Biotechnology Network (SDBN) ... SDBN BUZZ podcast focused on connecting the region’s biotech community and discussing topics ... the region and attract external employers, investors, scientists, and others who wish to ...
(Date:8/6/2019)... ... August 05, 2019 , ... Advanced Clinical, ... as a distinguished leader by PharmaVOICE magazine, earning him a prestigious spot on ... magazine’s July/August special issue. , As the executive vice president of business development ...
(Date:8/4/2019)... , ... August 02, 2019 , ... Cirtec Medical Corporation, ... devices, today announced that it has begun construction on a 30,000 sq. ft. ... miles from San Jose. , The facility, which is expected to be fully ...
(Date:7/26/2019)... ... July 25, 2019 , ... LeadingBiotech , an exclusive ... announces its Boston BD conference to be held on September 10, ... Boston , the event provides an opportunity for attendees to leverage insight from ...
Breaking Biology Technology:
Cached News: