HOME >> BIOLOGY >> NEWS
Fox Chase Cancer Center researchers make significant discovery about function of p53

PHILADELPHIA (February 2, 2003) -- Cancer researchers have known that the tumor-suppressor gene p53 is critical in preventing cells from dividing inappropriately and becoming tumors. But now, researchers at Fox Chase Cancer Center have established that the ability of the p53 gene to perform its job depends on the type of p53 within each cell. This and another new finding about p53, published in Nature Genetics (Feb. 3, 2003 online version, March 2003 print version), have implications for tailoring chemotherapy, designing new cancer treatments, and understanding how to treat cancer in certain populations.

The existence of two variants, or polymorphisms, of p53 isnt new, but weve discovered that the variant type in each cell can influence its tumor-suppressor ability, explains senior author Maureen Murphy, Ph.D., a molecular biologist in the pharmacology department of Fox Chase Cancer Center, Philadelphia, Pa.

When functioning properly, p53 polices cells for problems such as errant cellular growth, the hallmark of human cancer. If such harmful factors are present, p53 triggers the process of programmed cell death (known as apoptosis)-in effect, causing the bad cells to self-destruct. Alterations, or mutations, in this gene have been found in more than 60 percent of human cancers.

Murphy and her colleagues have known about the two p53 variants, but how the differences affect p53s ability to suppress tumor development was not previously understood until now.

People have one form or another of p53, says Murphy. The p53 variant containing the amino acid called arginine is better at killing out-of-control cells. The other p53 variant with the amino acid proline is less capable of stopping errant cells. When we asked if the two forms might function differently, the answer was a resounding yes.

In terms of treating cancer, patients could potentially be typed for the kind of p53 they have, some day allowing physicians to tailor their therapy.
'"/>

Contact: Karen Mallet
k_carter@fccc.edu
215-728-2700
Fox Chase Cancer Center
2-Feb-2003


Page: 1 2 3

Related biology news :

1. Fox Chase Cancer Centers Alfred Knudson Jr. named 2004 Kyoto Prize winner
2. Fox Chase discovery may help physicians diagnose, treat devastating childhood disease
3. Wilex & Fox Chase Cancer Center begin trial w/ novel compound targeting tumor invasion & metastasis
4. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
5. Fox Chase Cancer Center researchers identify significant smoking-induced genetic alteration
6. Fox Chase Cancer Center research reveals how COX-2 causes ovarian cancer
7. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
8. Fox Chase Cancer Center researcher develops new model for studying prions mad cow disease
9. Fox Chase Cancer Center study: Novel DNA-repair gene mutation can cause resistance to cancer drugs
10. NIH funds Breast Cancer and the Environmental Research Center at Fox Chase Cancer Center
11. Fox Chase Cancer Center receives grant to study possible link between measles vaccine and autism

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/1/2019)... ... April 01, 2019 , ... Stay on top of current hot topics through ... Access to all webinars is free, so be sure to register today to save ... http://www.xtalks.com to see our upcoming webinars: , CLINICAL TRIALS , April 2 ...
(Date:3/29/2019)... HAMBURG, Germany and WESTMINSTER, Colo. (PRWEB) , ... ... ... Indivumed and Flagship Biosciences, Inc. are pleased to announce a partnership ... clinical services to support advanced oncology diagnostics. , Under the terms ...
(Date:3/27/2019)... ... ... Evan Holden , a shareholder in the Atlanta office ... National Academy of Sciences (NAS) Roundtable on Biomedical Engineering Materials Applications (BEMA), March 25 ... Pharmaceutical, Medical Device & Health Care Litigation Practice , addressed, “Medical Device Liability—How ...
Breaking Biology News(10 mins):
(Date:4/16/2019)... ... April 16, 2019 , ... On ... project partner, the U.S. Army Center for Environmental Health Research (USACEHR), with an ... In-Licensing/Out-Licensing.” , Blue Sources, a veteran-owned company located at the Frederick Innovative Technology ...
(Date:4/12/2019)... Fla. (PRWEB) , ... April 12, 2019 , ... ... explore recent developments in neurotechnology and will educate about innovative tools and devices ... Check your local listings for more information. , This segment of Advancements will ...
(Date:4/9/2019)... ... April 09, 2019 , ... USDM ... capacity of life sciences organizations to accelerate innovation and maximize productivity, announces that ... the past 12 months. , USDM’s Cloud Assurance is a managed ...
(Date:4/8/2019)... BOSTON (PRWEB) , ... April 08, 2019 , ... ... enterprise-class unified communications and collaboration solutions, announced today the launch of their app ... an unprecedented range of business and contact-orientated applications while using CT Cloud Voice ...
Breaking Biology Technology:
Cached News: