Fox Chase Cancer Center study: Novel DNA-repair gene mutation can cause resistance to cancer drugs

he mismatch. If this fails, the system halts the cell's replication cycle and causes the new cell to die--literally, to pop out of its skin in a process called apoptosis.

In addition to helping cells circumvent DNA damage that might otherwise lead to cancer, the mismatch-repair system also plays a critical role in allowing anticancer drugs known as alkylating agents to kill cancer cells. These agents are the oldest and most widely used chemotherapy drugs. They work by damaging the DNA of cancer cells and triggering the mismatch-repair system to interrupt the reproductive cycle and cause apoptosis.

"Our finding that the defective MED1 enzyme produces resistance to these drugs is consistent with previous observations in cell culture models, which show that reduced mismatch-repair proteins cause tolerance or resistance to alkylating agents," Bellacosa explained. "However, it appears that small amounts of DNA damage can be dealt with effectively by reduced levels of these proteins while an effective response to anticancer drugs requires normal amounts."

The experiments by Bellacosa and his colleagues suggest that colorectal tumors with the MED1 deficiency may resist treatment not only with alkylating agents but also with other drugs used against colorectal cancer, such as irinotecan. The research used cell cultures of mouse cell lines, including mice in which the Med1 gene has been inactivated.

"Clinical validation of these hypotheses may have significant implications for treatment selection," Bellacosa and his co-authors conclude. "Additional understanding of the mechanisms of MED1 and mismatch-repair inactivation may suggest methods to overcome drug resistance."


Contact: Karen Carter Mallet
Fox Chase Cancer Center

Page: 1 2

Related biology news :

1. Fox Chase Cancer Centers Alfred Knudson Jr. named 2004 Kyoto Prize winner
2. Fox Chase discovery may help physicians diagnose, treat devastating childhood disease
3. Wilex & Fox Chase Cancer Center begin trial w/ novel compound targeting tumor invasion & metastasis
4. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
5. Fox Chase Cancer Center researchers identify significant smoking-induced genetic alteration
6. Fox Chase Cancer Center research reveals how COX-2 causes ovarian cancer
7. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
8. Fox Chase Cancer Center researcher develops new model for studying prions mad cow disease
9. NIH funds Breast Cancer and the Environmental Research Center at Fox Chase Cancer Center
10. Fox Chase Cancer Center researchers make significant discovery about function of p53
11. Fox Chase Cancer Center receives grant to study possible link between measles vaccine and autism

Post Your Comments:

(Date:4/28/2020)... ... April 27, 2020 , ... ... was started by three teenagers with an idea to help millions of people ... the time of great need and suffering, an outlet has been created for ...
(Date:4/22/2020)... ... April 20, 2020 , ... RCH Solutions (RCH ), a global ... announces the hiring of Michael Wlodarczyk as Director of Sales and Business Development. Based ... grow the company’s already strong presence across the Northeast. , “We continue to see ...
(Date:4/18/2020)... ... April 16, 2020 , ... SIRION Biotech GmbH , a world ... it will present a company update on its work expediting gene therapy research and ... on April 22 and 23. Dieter Lingelbach, the Company’s Chief Operating Officer, will also ...
Breaking Biology News(10 mins):
(Date:4/26/2020)... ... April 23, 2020 , ... Indegene Omnipresence, Inc. ... providing applications and services for use on Microsoft Azure. The customer experience management ... up online for a built-for-purpose customer engagement capability to use in their commercial ...
(Date:4/22/2020)... and CAMBRIDGE, Mass. (PRWEB) , ... April 20, ... ... Budapest with US offices in Cambridge, MA, announced today that Omixon’s founder and ... the early commercialisation of Omixon’s flagship product Holotype HLA since 2014 before stepping ...
(Date:4/22/2020)... ... April 21, 2020 , ... ... work through COVID-19. Many clinical trial teams are working remotely and have paused ... wants to help researchers continue their research during this uncertain time by giving ...
(Date:4/7/2020)... ... April 06, 2020 , ... Gateway Genomics , leading developer ... SneakPeek Early Gender DNA Tests sold in March, just months after attaining ... an ecommerce product, where a mom could order her kit online, collect a DNA ...
Breaking Biology Technology:
Cached News: