Knudson has been a senior member of the scientific research staff at Fox Chase Cancer Center since 1976. A geneticist and physician, Knudson is internationally recognized for his "two-hit" theory of cancer causation, which explained the relationship between the hereditary and non-hereditary forms of a cancer and predicted the existence of tumor-suppressor genes that can suppress cancer cell growth. This now-confirmed theory has advanced understanding of errors in the genetic program that turn normal cells into cancer cells.
Knudson's powerful insights into the development of cancer hold implications for both treatment and prevention. Tumor-suppressor genes, in particular, are important targets for prevention research since they normally function to apply the brakes to cellular growth. This is a topic of Knudson's current research.
Defects in tumor-suppressor genes permit abnormal, cancerous growth, so devising ways to remedy such flaws or replace the gene's missing product through medication are of interest to researchers.
The Inamori Foundation was established in 1984 by Kazuo Inamori, founder and chairman emeritus of Kyocera Corporation. The Kyoto Prizes were founded in 1985 in line with Inamori's belief that "man has no higher calling than to strive for the greater good of society, and that mankind's future can be assured only when there is a balance between our scientific progress and our spiritual depth." It is characteristic of the Kyoto Prizes that they are presented to individuals or groups in appreciation not only of their outstanding achievements but also of the excellence of the personal characteristics on which they have b
Contact: Karen C. Mallet
Fox Chase Cancer Center