HOME >> BIOLOGY >> NEWS
Fred Hutchinson Cancer Research Center to lead international team to accelerate investigation of immune-related genes

Known as the Rosetta Stone of immunology, knowledge of these genes will help predict disease susceptibility, understand treatment failure and gauge vaccine response.

A cluster of nearly 220 genes known as the human leukocyte antigen (HLA) gene complex holds clues to many unsolved medical questions: why do transplants sometimes fail despite close donor-recipient matches? What makes certain people more susceptible to specific diseases? Why do vaccines protect some individuals better than others?

In search of the answers, the National Institutes of Health (NIH) is heading an initiative to catalog the HLA gene complex and explore its differences among populations worldwide. Nearly $20 million over five years will go to the International Histocompatibilty Working Group (IHWG), a network of almost 200 laboratories in more than 70 countries, to set up a centralized HLA gene database and develop new and improved tools to decipher this genetic Rosetta Stone of immunology.

John A. Hansen, M.D., at the Fred Hutchinson Cancer Research Center (FHCRC) in Seattle, will lead the project. According to Dr. Hansen, head of FHCRC's Human Immunogenetics Program and a professor of medicine at the University of Washington, the project could have immediate clinical benefits, for example, for finding better matches for bone marrow transplant recipients.

"But the potential impact of these new studies goes way beyond the HLA community immunogenetics," says Dr. Hansen. "This project will apply recent advances in genome technology to important questions about specific diseases and help explain how the rich genetic differences in HLA between individuals can either strengthen the immune response or open the door to autoimmune disease and infection."

The HLA gene complex, known more generally as the major histocompatibility complex (MHC), is responsible for encoding proteins that stud the surface of the body's cells, marking them as our own. Anything not marked as "self
'"/>

Contact: Susan Edmonds
sedmonds@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
5-Sep-2000


Page: 1 2 3

Related biology news :

1. Intel and Fred Hutchinson to explore the use of nanotechnology tools for early disease detection
2. American Association for Cancer Research honors Fred Hutchinson Cancer Research Center investigator
3. Fred Hutchinson Cancer Research Center, University of Washington join in national effort to study health impact of toxic substances
4. Hutchinson Center researchers first to induce state of suspended animation in model vertebrate organism
5. Digging for genetic fossils: Hutchinson Center researchers solve structure of ancient biological molecule
6. Hutchinson Center researcher awarded Block lectureship
7. White House honors Hutchinson Center Scientist with Presidential Early Career Award
8. Hutchinson Center to lead $11.5 million ovarian-cancer research consortium
9. Fred Hutchinson Cancer Research Center researcher one of five awarded $1 million distinguished young scholars grant
10. Fred Hutchinson Cancer Research Center And Targeted Genetics Announces Issuance Of Braod Patent Covering Antigen-Specific T Cell Expansion
11. Hutchinson Center Director Wins Americas Nobel

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/17/2019)... (PRWEB) , ... July 16, 2019 , ... Imagine using ... or to detect bone loss before it causes osteoporosis. For South Dakota School of ... “This is potentially a game-changer in terms of our ability to monitor and prevent ...
(Date:7/9/2019)... ... July 09, 2019 , ... Murrieta Genomics, ... its incubator program. The founder and CEO of Tx Genetic, Helen Harrison, has ... those suffering from epithelial connective tissue disorders. , “We are pleased and excited ...
(Date:7/5/2019)... ... July 05, 2019 , ... ... bring its patented Tractus™ Platform to governments around the world. , Powered ... technology and point of care solutions to operating theatres worldwide to address new ...
Breaking Biology News(10 mins):
(Date:7/9/2019)... ... 2019 , ... Today, at the BIO World Congress on Industrial ... (NCGA) announced the winners of the Consider Corn Challenge II. Three winners were chosen, ... to produce biobased materials. , “Corn is a sustainable, abundant and affordable ...
(Date:6/18/2019)... ... June 18, 2019 , ... Personalized Stem Cells, Inc (“PSC”), ... to the FDA for use of a person’s own adipose-derived stem cells to treat ... in the knee. This IND is the first of several planned clinical trials ...
(Date:6/11/2019)... ... June 11, 2019 , ... Mytonomy, ... a national leader in opioid treatment, announced today they are partnering to combat ... Mytonomy recently deployed its virtual care platform at the Mayo Clinic to drive ...
(Date:5/31/2019)... Redwood City, California (PRWEB) , ... ... ... received allowance of our patent applications from the USPTO providing proprietary interest ... SYSTEM AND METHOD FOR SLEEP DISORDER DIAGNOSIS AND TREATMENT… extends Somnology’s IP ...
Breaking Biology Technology:
Cached News: