HOME >> BIOLOGY >> NEWS
Freezing human eggs - new findings point way to greater success

Freezing human eggs has proved one of the most difficult techniques to master in reproductive medicine and only about thirty babies have been born worldwide since the first attempts in 1986. But research published today*(Tuesday 27 February) in Europe's leading fertility journal, Human Reproduction, could lead to a significant improvement in success rates.

Italian fertility experts lead by Dr Rafaella Fabbri from the IVF Centre, Human Reproductive Medicine Unit at the University of Bologna, have identified crucial factors in the freeze-thaw process which contribute to the difference between success and failure. Putting their findings into practice in a laboratory study, they achieved a much higher than normal rate of egg survival and fertilised 57% by using ICSI (the injection of a single sperm into the egg). This is a figure comparable to fertilisation of fresh oocytes.

The key to their success was to increase the time the oocytes were exposed to the chemical protectants, propanediol plus sucrose, from around 10 minutes to 15 minutes and to double or even triple the normal amount of sugar (sucrose) in the freezing solution.

The main reason that human eggs disintegrate in the freezing process is inadequate dehydration. Longer exposure to the protectant and more help from the extra sucrose meant that the eggs were dehydrated gradually and more completely. This gentler freezing process minimised the formation of ice crystals, which can pierce the egg membrane and kill the cell.

The researchers further established that one factor thought to be important in successful cryopreservation - the presence of the protective nourishing cells surrounding the oocyte (cumulus oophorus) - did not actually have a bearing on success. There was no real difference in survival between eggs frozen with their cumulus oophorus partially removed or totally removed.

But, increasing the exposure time to the protectant and doubling the sucrose solution in the freezin
'"/>

Contact: Margaret Willson
m.willson@mwcommunications.org.uk
44-0-1536-772181
European Society for Human Reproduction and Embryology
26-Feb-2001


Page: 1 2 3 4

Related biology news :

1. Freezing cancer cells makes them prime targets for anti-cancer drug, new study finds
2. Scientists Trace Roots Of Protein That Keeps Antarctic Fish From Freezing
3. Climate change plus human pressure caused large mammal extinctions in late Pleistocene
4. Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better
5. Most recent common ancestor of all living humans surprisingly recent
6. Wildlife Conservation Society hosts public symposium on human-wildlife diseases
7. Bronfenbrenner book sums up human development
8. No role for simian virus 40 in human pleural mesotheliomas
9. Sugar-coated sea urchin eggs could have sweet implications for human fertility
10. Serotonin metabolites in mollusks suggest pathways for human therapies
11. Wrapping a memory with an experience, capacity for recollection detected in non-human species

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/5/2016)... 2016 http://www.researchandmarkets.com/research/5kvw8m/global_facial ) ... "Global Facial Recognition Market 2016-2020" report ... ) has announced the addition of the ... report to their offering. --> ... announced the addition of the "Global ...
(Date:2/3/2016)... 3, 2016 --> ... report "Automated Fingerprint Identification System Market by Component (Hardware ... (Banking & Finance, Government, Healthcare, and Transportation) and Geography ... market is expected to be worth USD 8.49 Billion ... 2015 and 2020. The transformation and technology evolution from ...
(Date:2/2/2016)... NEW YORK , Feb. 2, 2016 ... healthcare facilities are primarily focused on medical ... that measure point-of-care parameters. Wearable devices that ... a user,s freedom of movement are being ... sensors for human biomedical signal acquisition coupled ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... Feb. 11, 2016  Neurocrine Biosciences, Inc. (NASDAQ: NBIX ) ... December 31, 2015. --> --> ... net loss of $29.3 million, or $0.34 loss per share, compared ... share for the same period in 2014. For the year ended ... million, or $1.05 loss per share, as compared to a net ...
(Date:2/11/2016)... ATLANTA , Feb. 11, 2016  Spectra BioPharma ... Organization (CSO) that provides biopharma companies the experience, ... implement and deploy outsourced sales teams. Created in ... team addresses both the strategic and tactical needs ... innovative sales solutions through both personal and non-personal ...
(Date:2/11/2016)... 2016 --> ... (OTCQB: PSID), a life sciences company focused on ... subsidiary, which markets the Caregiver® FDA-cleared non-contact thermometer, ... January 2016, including entering into agreements with five ... growth, and establishing several near-term pipeline opportunities. ...
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... ... of its new stem cell treatment clinic in Quito, Ecuador. The new facility ... and trauma applications to patients from around the world. , The new ...
Breaking Biology Technology:
Cached News: