HOME >> BIOLOGY >> NEWS
Freezing human eggs - new findings point way to greater success

Freezing human eggs has proved one of the most difficult techniques to master in reproductive medicine and only about thirty babies have been born worldwide since the first attempts in 1986. But research published today*(Tuesday 27 February) in Europe's leading fertility journal, Human Reproduction, could lead to a significant improvement in success rates.

Italian fertility experts lead by Dr Rafaella Fabbri from the IVF Centre, Human Reproductive Medicine Unit at the University of Bologna, have identified crucial factors in the freeze-thaw process which contribute to the difference between success and failure. Putting their findings into practice in a laboratory study, they achieved a much higher than normal rate of egg survival and fertilised 57% by using ICSI (the injection of a single sperm into the egg). This is a figure comparable to fertilisation of fresh oocytes.

The key to their success was to increase the time the oocytes were exposed to the chemical protectants, propanediol plus sucrose, from around 10 minutes to 15 minutes and to double or even triple the normal amount of sugar (sucrose) in the freezing solution.

The main reason that human eggs disintegrate in the freezing process is inadequate dehydration. Longer exposure to the protectant and more help from the extra sucrose meant that the eggs were dehydrated gradually and more completely. This gentler freezing process minimised the formation of ice crystals, which can pierce the egg membrane and kill the cell.

The researchers further established that one factor thought to be important in successful cryopreservation - the presence of the protective nourishing cells surrounding the oocyte (cumulus oophorus) - did not actually have a bearing on success. There was no real difference in survival between eggs frozen with their cumulus oophorus partially removed or totally removed.

But, increasing the exposure time to the protectant and doubling the sucrose solution in the freezin
'"/>

Contact: Margaret Willson
m.willson@mwcommunications.org.uk
44-0-1536-772181
European Society for Human Reproduction and Embryology
26-Feb-2001


Page: 1 2 3 4

Related biology news :

1. Freezing cancer cells makes them prime targets for anti-cancer drug, new study finds
2. Scientists Trace Roots Of Protein That Keeps Antarctic Fish From Freezing
3. Climate change plus human pressure caused large mammal extinctions in late Pleistocene
4. Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better
5. Most recent common ancestor of all living humans surprisingly recent
6. Wildlife Conservation Society hosts public symposium on human-wildlife diseases
7. Bronfenbrenner book sums up human development
8. No role for simian virus 40 in human pleural mesotheliomas
9. Sugar-coated sea urchin eggs could have sweet implications for human fertility
10. Serotonin metabolites in mollusks suggest pathways for human therapies
11. Wrapping a memory with an experience, capacity for recollection detected in non-human species

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2017)... , March 29, 2017  higi, the health IT ... North America , today announced a ... the acquisition of EveryMove. The new investment and acquisition ... of tools to transform population health activities through the ... data. higi collects and secures data today ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based and Touchless), ... published by MarketsandMarkets, the market is expected to be worth USD 18.98 billion ... Continue Reading ... ...      (Logo: ...
(Date:3/20/2017)... Germany , March 20, 2017 At this ... Hamburg -based biometrics manufacturer DERMALOG. The Chancellor came to the DERMALOG ... is this year,s CeBIT partner country. At the largest German ... biometrics in use: fingerprint, face and iris recognition as well as DERMALOG´s ... ...
Breaking Biology News(10 mins):
(Date:6/15/2017)... ... June 15, 2017 , ... ... for DuPont Biofuels, will be speaking at Bloomberg’s 2017 Sustainable Business Summit: ... other leading environmental and sustainability officials on a panel titled “Developing a Corporate ...
(Date:6/14/2017)... ... ... a leading global provider for complete solutions for sample ... specific for ChIP-sequencing from the CeMM for low input ... allows the study of histone modifications and transcription factor ...
(Date:6/14/2017)... , ... June 13, 2017 ... ... holistic approach for understanding the phenotype of an organism on a molecular ... throughput and complicated data processing remain major bottlenecks to biomarker discovery in ...
(Date:6/13/2017)... (PRWEB) , ... June 13, 2017 , ... ... for GPU-accelerated deep learning research, today announced that it will offer the new ... GPUs based on the NVIDIA Volta™ architecture. , “NVIDIA’s DGX portfolio is paving ...
Breaking Biology Technology:
Cached News: