Freezing human eggs - new findings point way to greater success

ted the first study** to confirm that human ovarian follicles have the potential to grow and develop after freezing.

Two women due to undergo cancer treatment donated ovarian tissue. This was preserved and frozen in sucrose and the chemical propanediol, and, after thawing, grafted under the kidney capsules of immunodeficient mice. Unfrozen tissue was also grafted as a control.

There was no evidence of ovarian follicle development in the tissue at the time of grafting. But, when the grafts were recovered from the mice around 20 weeks later, the researchers identified normal antral follicles in the majority of both fresh and frozen tissue. Antral follicle development is the crucial stage shortly before ovulation, when a central cavity is formed in the follicle.

The leader of the research team, Dr Debra Gook of the Reproductive Services Unit at the Royal Women's Hospital, said: "Our study is the first to confirm normal growth and development of human follicles to the antral stage following cryopreservation. Although this is preliminary work, development of these follicles after 20 weeks within almost all of the grafts, suggests that development following grafting is reproducible. The high rate of functional preservation of follicles following cryopreservation also suggests that cryopreservation of ovarian tissues has real potential for clinical application."

** Development of antral follicles in human cryopreserved ovarian tissue following xenografting.Human Reproduction.Vol 16 No 3 pp 417-422

Growing mouse ovarian follicles - future tips for freezing human tissue? A study*** by two Sydney-based researchers is the first to show that pre-antral mouse follicles isolated from frozen and thawed ovarian tissue can be grown in-vitro to the point of antral development. They can also release mature eggs after being stimulated with human chorionic gonodatrophin - a hormone used to stimulate the ovaries in IVF treatment.

Dr Helen Newton and Dr Peter Il

Contact: Margaret Willson
European Society for Human Reproduction and Embryology

Page: 1 2 3 4

Related biology news :

1. Freezing cancer cells makes them prime targets for anti-cancer drug, new study finds
2. Scientists Trace Roots Of Protein That Keeps Antarctic Fish From Freezing
3. Climate change plus human pressure caused large mammal extinctions in late Pleistocene
4. Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better
5. Most recent common ancestor of all living humans surprisingly recent
6. Wildlife Conservation Society hosts public symposium on human-wildlife diseases
7. Bronfenbrenner book sums up human development
8. No role for simian virus 40 in human pleural mesotheliomas
9. Sugar-coated sea urchin eggs could have sweet implications for human fertility
10. Serotonin metabolites in mollusks suggest pathways for human therapies
11. Wrapping a memory with an experience, capacity for recollection detected in non-human species

Post Your Comments:

(Date:9/8/2019)... ... September 06, 2019 , ... The Board of Directors of ... the respective companies to proceed with a proposed business combination. After the ... a series of products leveraging the CRISPR-Chip technology. The closing of the ...
(Date:8/29/2019)... DIEGO (PRWEB) , ... August 28, 2019 , ... Lajollacooks4u ... The San Diego-based team building and cooking events company has seen record growth in ... Teams, such as Amazon, ServiceNow, Vistage and Illumina, have all visited the company’s La ...
(Date:8/27/2019)... ... August 27, 2019 , ... e3 ... to announce that it has partnered with Bertec, a leading manufacturer of force ... Balance Advantage systems, a full line of clinical systems for both assessment and ...
Breaking Biology News(10 mins):
(Date:8/23/2019)... Fla. (PRWEB) , ... August 22, 2019 , ... ... explore new drug delivery modalities and is scheduled to broadcast 4Q/2019. Check your ... Science’s (Avro) state-of-the-art skin patches for generic drug delivery. Focusing on therapeutics for ...
(Date:8/7/2019)... (PRWEB) , ... August 07, 2019 , ... Locus Agricultural ... breakthrough line of soil amendments (soil “probiotics”), including Rhizolizer ® , which is ... year—the largest impact any approach has offered to date. Results from the treatment of ...
(Date:8/4/2019)... (PRWEB) , ... August 02, 2019 , ... Cirtec Medical ... invasive devices, today announced that it has begun construction on a 30,000 sq. ft. ... 15 miles from San Jose. , The facility, which is expected to be ...
(Date:7/19/2019)... ... 18, 2019 , ... World renowned two-time Everest summiter Ravichandran ... California-based charity Coalition Duchenne for its 9th Annual Expedition Mt. Kinabalu in Sabah, ... for Duchenne muscular dystrophy and was founded by Sabahan Catherine Jayasuriya. , ...
Breaking Biology Technology:
Cached News: