HOME >> BIOLOGY >> NEWS
From algae, weeds and people: new genetic clues to complex obesity syndrome

By comparing the genomes of an alga, a weed and humans, a team of researchers has identified a new gene behind Bardet-Beidl syndrome (BBS), a complex condition marked by learning disabilities, vision loss and obesity.

"Finding this gene underscores the power of comparing organisms' complete genetic information," says Nicholas Katsanis, Ph.D., an assistant professor in the McKusick-Nathans Institute of Genetic Medicine at Johns Hopkins. "We can use this technique to look for new genes and proteins involved in specific cellular structures and their roles in health and disease."

That's because even very distantly related organisms -- the alga and humans, for example -- may share genes and proteins for common cellular structures that have been conserved by nature.

The genetic comparisons, done by researchers at Washington University in St. Louis, revealed 688 genes in humans and the alga that are involved in building cells' hair-like projections called cilia, the team reports in the May 14 issue of Cell.

In people, cilia help push fluid and molecules around outside certain cells, including some in the lung, eye, brain and kidney. Hopkins researchers and their colleagues have reported that genetic mutations in BBS cause problems at least in part by rendering cilia and related structures useless.

Two of the identified genes turned out to be located in a region of human chromosome 2 that already had been linked to BBS. Stimulated by the St. Louis researchers, the international BBS team sequenced the two genes in families with BBS and discovered mutations in one of the two genes.

"There were 230 possible genes in the region of chromosome 2 linked to BBS, and this genomic comparison immediately narrowed down the most likely possibilities to just two," says Katsanis, also an assistant professor of ophthalmology. "Using comparative genomics in this way is a big, big deal. It would have been nearly impossible to
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
13-May-2004


Page: 1 2 3

Related biology news :

1. Metal-eating algae, spartina eradication, horseshoe crabs
2. Lowly weeds may hold promise for curing host of common health woes
3. Using a companion crop to control weeds organically
4. Deer help disperse seeds--including noxious weeds
5. Seed dormancy may hold the key to fighting weeds
6. Invading weeds escaped old enemies, brought immunity
7. Molecular biology and biological control team up to thwart pests and weeds
8. Genetically modified crops may pass helpful traits to weeds, study finds
9. Genes passed from crops to weeds persist for generations
10. Radioactive tumbleweeds
11. Researchers determine genetic cause of Timothy syndrome

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: From algae weeds and people new genetic clues complex obesity syndrome

(Date:10/31/2014)... study confirms that endangered musk deer still live in ... Species targeted by poachers: Musk deer scent glands are ... October issue of the journal Oryx , ... years after its last confirmed sighting, a strange deer ... slopes of northeast Afghanistan according to a research team ...
(Date:10/31/2014)... creating green space in cities is good for attracting species, ... built environments, a University of Iowa study has found. , ... area in Iowa, and recorded the abundance of two insects ... plenty of the trees, black cherry and black walnut, they ... case fruit flies that feed on the walnuts and black ...
(Date:10/31/2014)... Thomas Bugnyar and his team have been studying ... the Northern Austrian Alps for years. They observed ... such as grooming and playing. However, they also ... by a third individual. Although in about 50 ... and broke up the two affiliating ravens, intervening ...
Breaking Biology News(10 mins):Strange, fanged deer persists in Afghanistan 2Green spaces don't ensure biodiversity in urban areas 2
(Date:10/31/2014)... October 31, 2014 The report ... Rice), Formulation (Plain, Flavored, Sweetened, Unsweetened), Channel (Supermarket, ... Global Trends & Forecast to 2018," defines and ... analysis and forecast of revenue and volume for ... is projected to reach $14 Billion by 2018 ...
(Date:10/31/2014)... ORLANDO, Fla. , Oct. 31, 2014 /PRNewswire/ ... firm owned by Tavistock Group, celebrated the groundbreaking of ... Nona Medical City. The 92,000-square-foot, ... Central Florida designed specifically ... Located in the heart of the 650-acre Lake ...
(Date:10/30/2014)... , Oct. 30, 2014  Ardelyx, Inc. (NASDAQ: ... focused on cardio-renal, gastrointestinal and metabolic diseases, today ... financial results on Thursday, November 6, 2014. Following ... a live conference call and webcast at 4:30pm ... provide a business update. The live ...
(Date:10/30/2014)... MA (PRWEB) October 30, 2014 ... and collaboration provider, offers Office 365 end users ... into a complete phone system by adding voice ... 365 (O365) includes Lync Online, a communication tool ... Lync calls. With hosted voice, O365 becomes a ...
Breaking Biology Technology:Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 2Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 3Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 4GuideWell Innovation Center Groundbreaking Hosted by Tavistock Development Company at Lake Nona Medical City 2GuideWell Innovation Center Groundbreaking Hosted by Tavistock Development Company at Lake Nona Medical City 3Ardelyx to Report Third Quarter 2014 Financial Results on November 6, 2014 2SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 2SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 3
Cached News: