From biodefense to prostate cancer offense

FOR IMMEDIATE RELEASE: (SACRAMENTO, Calif.) -- Two molecular geneticists at the UC Davis Cancer Center have won $1.1 million in grants to turn biodefense technology into a new prostate cancer offense. The grants were awarded by the U.S. Department of Defense Prostate Cancer Research Program.

Paul Gumerlock, professor of hematology/oncology, received a three-year, $557,000 grant to test a new gene-silencing method, developed last summer at Lawrence Livermore National Laboratory. Gumerlock will use the new method to silence certain DNA repair genes in prostate cancer cells. By doing so, he hopes to make the cancer cells more vulnerable to radiation therapy.

Philip Mack, a research geneticist, received a three-year, $334,000 grant to test the same gene-silencing method, known as siHybrid technology, against certain mutations of the p53 tumor suppressor gene. Mack will test whether silencing the mutations can help to prevent androgen independence, a poorly understood process that renders prostate cancer untreatable.

"Preventing or delaying the emergence of androgen independence, and perhaps even reversing it after it has occurred, would provide new treatment options and greatly impact overall patient survival," Mack says.

Gumerlock also received a second, 18-month grant for $111,000 to exploit two other biodefense technologies fresh from the Lawrence Livermore National Laboratory. One is a method of affixing cell-free DNA fragments to chips of glass, so the fragile fragments can be examined without being damaged. The other is a technique, known as in situ rolling circle amplification, which allows minute DNA fragments to be detected in the bloodstream with much greater sensitivity than previous methods.

Using the new techniques, Gumerlock intends to develop a blood test that can detect methylated, or deactivated, gene sequences common in prostate cancers. Methylation is a process commonly used by cancer cells to shut down tumo

Contact: Claudia Morain
916 734-9023
University of California, Davis - Health System

Page: 1 2

Related biology news :

1. PNNL lands $10.3 million NIH biodefense contract to unlock proteomes of salmonella and pox
2. Project BioShield: Consistent financing, markets, indemnity for biodefense vaccine developers needed
3. ASM biodefense meeting scheduled for March 2003
4. Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better
5. Researchers identify distinctive signature for metastatic prostate cancer
6. Charting the future in prostate cancer care: A call to action
7. Study reveals first genetic step necessary for prostate cancer growth
8. Study narrows search for genes placing men at increased risk for prostate cancer
9. MICs shed light on prostate cancer
10. Alterations in vitamin D receptor gene increase prostate, breast cancer risk
11. New prostate cancer gene identified

Post Your Comments:

(Date:1/20/2019)... SAN DIEGO (PRWEB) , ... January 16, 2019 , ... ... building and cooking events company. Not only has the company already hosted several ... to host Fortune 500 companies, Amazon and Janssen Pharmaceuticals, later this month. , ...
(Date:1/10/2019)... ... ... Dr. Beanlands is the Vered Chair and Division Head of Cardiology at the ... of its National Cardiac PET Centre, and Professor in the University's Division of Cardiology ... of Cellular and Molecular medicine. , He is a founding member of ASNC, member ...
(Date:1/8/2019)... and RALEIGH, N.C. (PRWEB) , ... January 07, ... ... micro acoustic and micro mechanical technologies and solutions for hearing instruments and specialty ... today announced BiometRIC, the first ever hearing aid receiver in canal with an ...
Breaking Biology News(10 mins):
(Date:1/8/2019)... ... ... The American Society of Gene and Cell Therapy’s (ASGCT) first ... up of industry leaders identified by the ASGCT board of directors. In total, the ... support ASGCT members designing transformative pilot studies in gene and cell therapy as they ...
(Date:1/4/2019)... ... January 01, 2019 , ... uBiome, the ... World Economic Forum Annual Meeting January 22-25, 2019 held in Davos-Klosters, Switzerland following ... World Economic Forum Annual Meeting brings together leaders of global society–the heads and ...
(Date:12/20/2018)... ... December 20, 2018 , ... New Year’s brings reflection ... changes in regulations in the European Union (EU) on the horizon, Jim Kasic, president ... , “The transition to the EU Medical Device Regulation (MDR), digital health, and big ...
(Date:12/18/2018)... ... 17, 2018 , ... ABCT , the Accelerator for ... to participate in the annual program. Twelve ventures will participate in the 6.5-month-long ... network. All startups receive an entrepreneur coach, access to active business professionals and ...
Breaking Biology Technology:
Cached News: