HOME >> BIOLOGY >> NEWS
From biodefense to prostate cancer offense

FOR IMMEDIATE RELEASE: (SACRAMENTO, Calif.) -- Two molecular geneticists at the UC Davis Cancer Center have won $1.1 million in grants to turn biodefense technology into a new prostate cancer offense. The grants were awarded by the U.S. Department of Defense Prostate Cancer Research Program.

Paul Gumerlock, professor of hematology/oncology, received a three-year, $557,000 grant to test a new gene-silencing method, developed last summer at Lawrence Livermore National Laboratory. Gumerlock will use the new method to silence certain DNA repair genes in prostate cancer cells. By doing so, he hopes to make the cancer cells more vulnerable to radiation therapy.

Philip Mack, a research geneticist, received a three-year, $334,000 grant to test the same gene-silencing method, known as siHybrid technology, against certain mutations of the p53 tumor suppressor gene. Mack will test whether silencing the mutations can help to prevent androgen independence, a poorly understood process that renders prostate cancer untreatable.

"Preventing or delaying the emergence of androgen independence, and perhaps even reversing it after it has occurred, would provide new treatment options and greatly impact overall patient survival," Mack says.

Gumerlock also received a second, 18-month grant for $111,000 to exploit two other biodefense technologies fresh from the Lawrence Livermore National Laboratory. One is a method of affixing cell-free DNA fragments to chips of glass, so the fragile fragments can be examined without being damaged. The other is a technique, known as in situ rolling circle amplification, which allows minute DNA fragments to be detected in the bloodstream with much greater sensitivity than previous methods.

Using the new techniques, Gumerlock intends to develop a blood test that can detect methylated, or deactivated, gene sequences common in prostate cancers. Methylation is a process commonly used by cancer cells to shut down tumo
'"/>

Contact: Claudia Morain
claudia.morain@ucdmc.ucdavis.edu
916 734-9023
University of California, Davis - Health System
4-May-2004


Page: 1 2

Related biology news :

1. PNNL lands $10.3 million NIH biodefense contract to unlock proteomes of salmonella and pox
2. Project BioShield: Consistent financing, markets, indemnity for biodefense vaccine developers needed
3. ASM biodefense meeting scheduled for March 2003
4. Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better
5. Researchers identify distinctive signature for metastatic prostate cancer
6. Charting the future in prostate cancer care: A call to action
7. Study reveals first genetic step necessary for prostate cancer growth
8. Study narrows search for genes placing men at increased risk for prostate cancer
9. MICs shed light on prostate cancer
10. Alterations in vitamin D receptor gene increase prostate, breast cancer risk
11. New prostate cancer gene identified

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/13/2019)... ... June 13, 2019 , ... Global Clinical and Ancillary ... end-to-end clinical and ancillary supply chain management needs of large- and middle-market pharmaceutical, ... today announced it will sponsor a summer education program offered by the Young ...
(Date:6/6/2019)... ... June 05, 2019 , ... ... opening of a new network station and service center in Mexico City, Mexico. ... in the world — with more than $1.75 billion in pharmaceutical exports since ...
(Date:6/4/2019)... ... June 04, 2019 , ... Harper was three years ... X-rays revealed severe elbow dysplasia, which caused painful osteoarthritis in the joints. She ... Her parents were heartbroken. , The surgical specialist, Dr. Christopher Eich of Southern ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... Redwood City, California (PRWEB) , ... ... ... received allowance of our patent applications from the USPTO providing proprietary interest ... SYSTEM AND METHOD FOR SLEEP DISORDER DIAGNOSIS AND TREATMENT… extends Somnology’s IP ...
(Date:5/21/2019)... ... May 21, 2019 , ... ... today officially opened the inaugural Africa Brewing Conference dedicated to sharing brewing knowledge, ... Africa. The event, which is supported through a partnership with “Ethiopia Invest”, will ...
(Date:5/8/2019)... ... ... at 16.2 hands, Atlas is on the large side for a Quarter Horse. He ... other activities. When loping around a corner in late 2017, Atlas tripped and partially ... only being able to walk. Fortunately Atlas’ owner, Kelly, sought the opinion of her ...
(Date:5/2/2019)... ... 2019 , ... The centuries old practice of brewing beer thrives today across ... and even home brewing clubs scattered across the nation. , But proper beer ... can produce a superb product. Students at South Dakota School of Mines & ...
Breaking Biology Technology:
Cached News: