HOME >> BIOLOGY >> NEWS
From lung to gut the Wnt signaling pathway transforms cell fate

Researchers have uncovered a cellular mechanism that can alter the fate of progenitor cells that normally generate the lung, causing them to create gut cells instead. The findings, which are published this week in the top-tier Open Access journal, Journal of Biology, could help researchers hoping to use adult stem cells for therapeutic purposes.

Brigid Hogan and Tadashi Okubo, from Duke University Medical Center, studied the lungs of transgenic mice that had developed under the influence of artificially high levels of activity in the Wnt signaling pathway, caused by the presence of an activated b catenin gene. They found that although externally the lungs looked normal, the interior of the lungs had lost the normal branching tree-like structure lined with rounded alveolar cells. Instead, a few wide bronchial tubes opened directly into large sacs that were lined with a rapidly proliferating cuboidal epithelium.

Looking more closely at these epithelial cells, the researchers found that many of them were not expressing genes typical of lung cells, such as the genes encoding secretoglobin and surfactants. In addition, microarrays comparing the transgenic cells with normal lung epithelial cells showed a general reduction in the expression of lung-specific genes and a strong expression, instead, of genes characteristic of intestinal cells.

"A striking feature of the microarray data was the high expression in transgenic lungs of genes normally associated with the specification and differentiation of gut secretory cell lineages," say Hogan and Okubo. These included the gene encoding the Atoh1 transcription factor, which is normally turned off in lung cells.

"In particular there was a very high level of expression of genes characteristic of Paneth cells, which are normally found in the base of crypts in the small intestine," they continue.

Signaling downstream of b catenin normally occurs in cells that have been activated by molecules
'"/>

Contact: Gemma Bradley
press@biomedcentral.com
44-207-631-9931
BioMed Central
7-Jun-2004


Page: 1 2

Related biology news :

1. Activated signaling pathway may predict lung cancer patients response to gefitinib
2. NRH1 and Wnt signaling come together in convergent extension
3. Equine clonings triple play sheds light on calcium, cell signaling, human disease
4. UT Southwestern researchers learn importance of insulin family signaling in male sex determination
5. Mantis shrimp fluoresce to enhance signaling in the dim ocean depths
6. OHSU researchers discover molecular signaling system controlling aspects of embryonic development
7. New study identifies gene signaling puberty
8. Are the bright colors of some avian eggs signaling female genetic quality to their mates?
9. Scientists map signaling molecule crucial to survival, disease
10. Researchers identify molecular signaling system that is crucial for plant fertility
11. Plants and people share a molecular signaling system, researchers discover

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/19/2020)... , ... June 18, 2020 ... ... webinar series, “Automate Your Lab with Software for Data Decisions,” for pharmaceutical ... learn how to integrate and automate cutting-edge scientific instruments and laboratory equipment ...
(Date:6/13/2020)... LORTON, Va. (PRWEB) , ... June 11, 2020 ... ... of forensic DNA services, announces a significant expansion of its forensic genealogy team. ... law enforcement and attorneys through proven forensic genealogy and DNA analysis methods. The ...
(Date:6/11/2020)... ... ... Superior Controls, Inc. , an E Technologies Company and leading U.S. ... industry, is pleased to announce the recent hiring of Ray Boudreau, who will be ... office. In his new role, Boudreau will use his extensive experience with business ...
Breaking Biology News(10 mins):
(Date:7/7/2020)... , ... July 06, 2020 , ... ... Awards. Entries from Roche, Eli Lilly, Bristol-Myers Squibb, the University of Chicago, Massachusetts ... Bio-IT World has hosted an elite awards program, highlighting outstanding examples of how ...
(Date:6/28/2020)... , ... June 25, 2020 , ... ... racing to develop a vaccine or drug treatment. In an effort to better ... has publicly released the world’s largest imaging dataset portraying therapeutic compound effects from ...
(Date:6/23/2020)... , ... June 22, 2020 , ... ... offering an Amniosomes special offer. This includes buy three, get the fourth unit ... (888) 568-6909. , Amniotic derived exosomes, known as exosomes, have been a game ...
(Date:6/11/2020)... ... June 09, 2020 , ... PathSensors Inc., a Baltimore ... Innovation Research (SBIR) program funded by the National Institute of Food and Agriculture ... Field”. The project’s goal was to engineer and develop a field-deployable instrument for ...
Breaking Biology Technology:
Cached News: