HOME >> BIOLOGY >> NEWS
Fruit Flies May Shed Light On Cocaine Addiction

Two geneticists have found that fruit flies respond in the same way to "crack" cocaine as do other animals, including humans. Because humans and fruit flies use many similar biochemical pathways, this discovery suggests that the flies may help scientists unravel the molecular basis of cocaine addiction in people. It may also lay the foundation for highly specific drugs to treat cocaine addiction.

The research, performed by Dr. Jay Hirsh and Colleen McClung of the University of Virginia in Charlottesville, grew out of the group's long-term genetic studies on brain receptors and neurotransmitters--such as dopamine and serotonin--involved in learning, memory, and motor function. Their current findings are featured in a cover story in the January 15 issue of Current Biology.

Cocaine is one of the most powerfully addictive street drugs. Extensive studies on rodents and monkeys have provided little information about the molecular processes that underlie cocaine's behavioral and addictive effects. Using fruit flies in such studies offers several advantages. The genetics of the flies have been intensively studied for 80 years, providing researchers with a rich information base from which to devise and interpret experiments. Not insignificantly, research on flies is cheaper, easier, and faster than similar studies on mammals.

The flies, formally called Drosophila melanogaster, reacted in striking and reproducible ways in response to different levels of cocaine. They also became "sensitized" to the drug, a physiological process thought to be involved in human drug addiction.

"This study shows that the nature of the changes in the Drosophila brain and nervous system in response to cocaine are probably very similar to those that occur in the human brain. This gives us a new tool to learn more about brain receptors and neurotransmitters, and also to better understand the genetic and ph
'"/>

Contact: Alisa Zapp Machalek
alisa.zapp@nih.gov
(301) 496-7301
NIH/National Institute of General Medical Sciences
13-Jan-1998


Page: 1 2 3

Related biology news :

1. Fruits offer powerful protection from skin cancer
2. Fruit odors lure some flies to evolve into new species
3. Fruit fly pheromone receptor first ever discovered linked to specific sexual behavior
4. Fruit consumption related to increased risk of Parkinsons?
5. Fruit fly cells reveal Hedgehogs secrets
6. Fruit flies unlock Methuselahs secrets
7. Fruit fly model could explain how mosquitoes carry malaria: new drugs and vaccines on the horizon
8. Fruit flys genome sequence finished in record time: Physical maps are the key to accuracy
9. Research Bears Fruit, And Patents
10. Compounds From Fruits, Vegetables And Grains Slow The Growth Of Human Tumor Cells
11. Variations In The Human Homologue Of A Fruit Fly Gene Are Associated With Mood And Panic Disorders

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... 2017  Veratad Technologies, LLC ( www.veratad.com ), an ... identity verification solutions, announced today they will participate as ... 15 thru May 17, 2017, in Washington ... Center. Identity impacts the lives of ... quickly evolving digital world, defining identity is critical to ...
(Date:4/19/2017)... , April 19, 2017 ... its vendor landscape is marked by the presence of ... is however held by five major players - 3M ... these companies accounted for nearly 61% of the global ... leading companies in the global military biometrics market boast ...
(Date:4/13/2017)... PUNE, India , April 13, 2017 According ... Identity Proofing, Identity Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication ... by MarketsandMarkets™, the IAM Market is expected to grow from USD 14.30 ... Annual Growth Rate (CAGR) of 17.3%. ... ...
Breaking Biology News(10 mins):
(Date:8/23/2017)... ... August 23, 2017 , ... The Excelera network ... The network provides members nationally scaled infrastructure and support to help them develop ... agreements so members can provide continuity of care for their patients with complex ...
(Date:8/22/2017)... Worcester. MA (PRWEB) , ... August 22, 2017 ... ... a new service pipeline built upon patented KBioBox technology, the extended GUIDE-Seq ananlysis. ... open source GUIDE-Seq computation pipeline to be provide scientists with easy to understand ...
(Date:8/21/2017)... ... August 21, 2017 , ... Finalists ... awards recognize medical centers that have implemented innovative products, services, and technology over ... protocols, competitive advantages, financial impact/value, and market need. The applicants with the top ...
(Date:8/21/2017)... ... August 21, 2017 , ... The team at ... webinar, in which attendees will learn about the assembly and topological architecture of ... an overview of the development and validation of new high-quality recombinant monoclonal antibodies, ...
Breaking Biology Technology:
Cached News: