HOME >> BIOLOGY >> NEWS
Fruit Flies May Shed Light On Cocaine Addiction

Two geneticists have found that fruit flies respond in the same way to "crack" cocaine as do other animals, including humans. Because humans and fruit flies use many similar biochemical pathways, this discovery suggests that the flies may help scientists unravel the molecular basis of cocaine addiction in people. It may also lay the foundation for highly specific drugs to treat cocaine addiction.

The research, performed by Dr. Jay Hirsh and Colleen McClung of the University of Virginia in Charlottesville, grew out of the group's long-term genetic studies on brain receptors and neurotransmitters--such as dopamine and serotonin--involved in learning, memory, and motor function. Their current findings are featured in a cover story in the January 15 issue of Current Biology.

Cocaine is one of the most powerfully addictive street drugs. Extensive studies on rodents and monkeys have provided little information about the molecular processes that underlie cocaine's behavioral and addictive effects. Using fruit flies in such studies offers several advantages. The genetics of the flies have been intensively studied for 80 years, providing researchers with a rich information base from which to devise and interpret experiments. Not insignificantly, research on flies is cheaper, easier, and faster than similar studies on mammals.

The flies, formally called Drosophila melanogaster, reacted in striking and reproducible ways in response to different levels of cocaine. They also became "sensitized" to the drug, a physiological process thought to be involved in human drug addiction.

"This study shows that the nature of the changes in the Drosophila brain and nervous system in response to cocaine are probably very similar to those that occur in the human brain. This gives us a new tool to learn more about brain receptors and neurotransmitters, and also to better understand the genetic and ph
'"/>

Contact: Alisa Zapp Machalek
alisa.zapp@nih.gov
(301) 496-7301
NIH/National Institute of General Medical Sciences
13-Jan-1998


Page: 1 2 3

Related biology news :

1. Fruits offer powerful protection from skin cancer
2. Fruit odors lure some flies to evolve into new species
3. Fruit fly pheromone receptor first ever discovered linked to specific sexual behavior
4. Fruit consumption related to increased risk of Parkinsons?
5. Fruit fly cells reveal Hedgehogs secrets
6. Fruit flies unlock Methuselahs secrets
7. Fruit fly model could explain how mosquitoes carry malaria: new drugs and vaccines on the horizon
8. Fruit flys genome sequence finished in record time: Physical maps are the key to accuracy
9. Research Bears Fruit, And Patents
10. Compounds From Fruits, Vegetables And Grains Slow The Growth Of Human Tumor Cells
11. Variations In The Human Homologue Of A Fruit Fly Gene Are Associated With Mood And Panic Disorders

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/1/2016)... 1, 2016 Favorable Government Initiatives ... and Criminal Identification to Boost Global Biometrics System Market ... TechSci Research report, " Global Biometrics Market By ... and Opportunities, 2011 - 2021", the global biometrics market ... on account of growing security concerns across various end ...
(Date:5/16/2016)... 2016   EyeLock LLC , a market leader ... of an IoT Center of Excellence in ... development of embedded iris biometric applications. EyeLock,s ... and security with unmatched biometric accuracy, making it the ... DNA. EyeLock,s platform uses video technology to deliver a ...
(Date:5/3/2016)... 2016  Neurotechnology, a provider of high-precision biometric ... Biometric Identification System (ABIS) , a complete system ... ABIS can process multiple complex biometric transactions with ... fingerprint, face or iris biometrics. It leverages the ... MegaMatcher Accelerator , which have been used ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... -- A person commits a crime, and the detective uses ... criminal down. An outbreak of foodborne illness makes ... uses DNA evidence to track down the bacteria that caused ... not. The FDA has increasingly used a complex, cutting-edge technology ... Put as simply as possible, whole genome sequencing is a ...
(Date:6/23/2016)... , June 23, 2016  The Prostate Cancer Foundation (PCF) is ... treatments and faster cures for prostate cancer. Members of the Class of 2016 ... countries. Read More About the Class of 2016 PCF ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the Industry ... Supplyframe Design Lab . Located in Pasadena, Calif., the Design Lab’s mission ... hardware projects are designed, built and brought to market. , The Design Lab ...
(Date:6/23/2016)... Ky. , June 23, 2016 ... two Phase 1 clinical trials of its complement ... placebo-controlled, single and multiple ascending dose studies designed ... pharmacodynamics (PD) of subcutaneous injection in healthy adult ... subcutaneously (SC) either as a single dose (ranging ...
Breaking Biology Technology:
Cached News: