HOME >> BIOLOGY >> NEWS
Fruit Flies May Shed Light On Cocaine Addiction

Two geneticists have found that fruit flies respond in the same way to "crack" cocaine as do other animals, including humans. Because humans and fruit flies use many similar biochemical pathways, this discovery suggests that the flies may help scientists unravel the molecular basis of cocaine addiction in people. It may also lay the foundation for highly specific drugs to treat cocaine addiction.

The research, performed by Dr. Jay Hirsh and Colleen McClung of the University of Virginia in Charlottesville, grew out of the group's long-term genetic studies on brain receptors and neurotransmitters--such as dopamine and serotonin--involved in learning, memory, and motor function. Their current findings are featured in a cover story in the January 15 issue of Current Biology.

Cocaine is one of the most powerfully addictive street drugs. Extensive studies on rodents and monkeys have provided little information about the molecular processes that underlie cocaine's behavioral and addictive effects. Using fruit flies in such studies offers several advantages. The genetics of the flies have been intensively studied for 80 years, providing researchers with a rich information base from which to devise and interpret experiments. Not insignificantly, research on flies is cheaper, easier, and faster than similar studies on mammals.

The flies, formally called Drosophila melanogaster, reacted in striking and reproducible ways in response to different levels of cocaine. They also became "sensitized" to the drug, a physiological process thought to be involved in human drug addiction.

"This study shows that the nature of the changes in the Drosophila brain and nervous system in response to cocaine are probably very similar to those that occur in the human brain. This gives us a new tool to learn more about brain receptors and neurotransmitters, and also to better understand the genetic and ph
'"/>

Contact: Alisa Zapp Machalek
alisa.zapp@nih.gov
(301) 496-7301
NIH/National Institute of General Medical Sciences
13-Jan-1998


Page: 1 2 3

Related biology news :

1. Fruits offer powerful protection from skin cancer
2. Fruit odors lure some flies to evolve into new species
3. Fruit fly pheromone receptor first ever discovered linked to specific sexual behavior
4. Fruit consumption related to increased risk of Parkinsons?
5. Fruit fly cells reveal Hedgehogs secrets
6. Fruit flies unlock Methuselahs secrets
7. Fruit fly model could explain how mosquitoes carry malaria: new drugs and vaccines on the horizon
8. Fruit flys genome sequence finished in record time: Physical maps are the key to accuracy
9. Research Bears Fruit, And Patents
10. Compounds From Fruits, Vegetables And Grains Slow The Growth Of Human Tumor Cells
11. Variations In The Human Homologue Of A Fruit Fly Gene Are Associated With Mood And Panic Disorders

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Fruit Flies May Shed Light Cocaine Addiction

(Date:3/23/2015)... LOS ANGELES , March 23, 2015  In ... in Federal fraud case conviction losses. This figure accounts ... fraud, which, according to The Nilson Report, exceeds $11 ... an investigative tool after a crime has occurred. Investor ... Agent and polygraph expert Joe Paolella partnered ...
(Date:3/20/2015)... , Mar. 19, 2015 Research and Markets ... "Iris Biometrics - Global Strategic Business Report" report ... markets for Iris Biometrics in US$ Thousands. The report provides ... , Japan , Europe ... , and Latin America . ...
(Date:3/17/2015)...  MecklerMedia Corporation (OTCQX: MECK) announced its ... ever held in New York City ... 2015 at the Javits Convention Center. ... Acorn Product Development; Axis NJ; c-Link Systems; CoroWare; ... NewBotic Corporation; Neya Systems LLC; Reliabotics; RoboKind; RocketFarm ...
Breaking Biology News(10 mins):Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5MecklerMedia's RoboUniverse New York Announces Sponsors and Exhibitors, May 11-13, 2015 2
(Date:3/30/2015)... 2015 CASI Pharmaceuticals, Inc. (Nasdaq: CASI ... and commercialization of innovative therapeutics addressing cancer and other ... commercial focus on China , announced ... has approved the Company,s application to conduct a Phase ... (OCCC) patients for its proprietary drug candidate ENMD-2076.  ...
(Date:3/30/2015)... CARDIFF, UK, and BELLINGHAM, Washington, USA (PRWEB) March 29, ... energy projects in Europe and the United States and ... programme highlights planned for SPIE Optics + Optoelectronics ... will feature over 700 technical presentations in 17 conferences ... international society for optics and photonics , the event ...
(Date:3/30/2015)... MADISON, Wis. , March 30, 2015  FUJIFILM ... ("Fujifilm") and Cellular Dynamics International, Inc. (CEO: Robert ... leading developer and manufacturer of fully functioning human cells ... the two companies have entered into a definitive agreement ... offer to be followed by a second step merger. ...
(Date:3/29/2015)... March 29, 2015 As a symbol ... required by our pharmaceutical manufacturing clients, Whitehouse Laboratories is ... of the Berkenstock Race Team for the 2015 race ... only speed, but a strong sense of precision and ... lead to success in the quality control testing laboratory. ...
Breaking Biology Technology:CASI Pharmaceuticals Receives Approval From CFDA For Phase 2 Clinical Trial In China With ENMD-2076 For Ovarian Clear Cell Carcinoma 2CASI Pharmaceuticals Receives Approval From CFDA For Phase 2 Clinical Trial In China With ENMD-2076 For Ovarian Clear Cell Carcinoma 3CASI Pharmaceuticals Receives Approval From CFDA For Phase 2 Clinical Trial In China With ENMD-2076 For Ovarian Clear Cell Carcinoma 4CASI Pharmaceuticals Receives Approval From CFDA For Phase 2 Clinical Trial In China With ENMD-2076 For Ovarian Clear Cell Carcinoma 5Laser Energy Advances Among Reports Set for SPIE Optics + Optoelectronics 2Laser Energy Advances Among Reports Set for SPIE Optics + Optoelectronics 3Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 2Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 3Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 4Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 5Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 6Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 7Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 8Whitehouse Laboratories Reaffirms Commitment to Speedy Results – Renews Sponsorship of Berkenstock Racing Team 2
Cached News: