HOME >> BIOLOGY >> NEWS
Fruit Flies May Shed Light On Cocaine Addiction

Two geneticists have found that fruit flies respond in the same way to "crack" cocaine as do other animals, including humans. Because humans and fruit flies use many similar biochemical pathways, this discovery suggests that the flies may help scientists unravel the molecular basis of cocaine addiction in people. It may also lay the foundation for highly specific drugs to treat cocaine addiction.

The research, performed by Dr. Jay Hirsh and Colleen McClung of the University of Virginia in Charlottesville, grew out of the group's long-term genetic studies on brain receptors and neurotransmitters--such as dopamine and serotonin--involved in learning, memory, and motor function. Their current findings are featured in a cover story in the January 15 issue of Current Biology.

Cocaine is one of the most powerfully addictive street drugs. Extensive studies on rodents and monkeys have provided little information about the molecular processes that underlie cocaine's behavioral and addictive effects. Using fruit flies in such studies offers several advantages. The genetics of the flies have been intensively studied for 80 years, providing researchers with a rich information base from which to devise and interpret experiments. Not insignificantly, research on flies is cheaper, easier, and faster than similar studies on mammals.

The flies, formally called Drosophila melanogaster, reacted in striking and reproducible ways in response to different levels of cocaine. They also became "sensitized" to the drug, a physiological process thought to be involved in human drug addiction.

"This study shows that the nature of the changes in the Drosophila brain and nervous system in response to cocaine are probably very similar to those that occur in the human brain. This gives us a new tool to learn more about brain receptors and neurotransmitters, and also to better understand the genetic and ph
'"/>

Contact: Alisa Zapp Machalek
alisa.zapp@nih.gov
(301) 496-7301
NIH/National Institute of General Medical Sciences
13-Jan-1998


Page: 1 2 3

Related biology news :

1. Fruits offer powerful protection from skin cancer
2. Fruit odors lure some flies to evolve into new species
3. Fruit fly pheromone receptor first ever discovered linked to specific sexual behavior
4. Fruit consumption related to increased risk of Parkinsons?
5. Fruit fly cells reveal Hedgehogs secrets
6. Fruit flies unlock Methuselahs secrets
7. Fruit fly model could explain how mosquitoes carry malaria: new drugs and vaccines on the horizon
8. Fruit flys genome sequence finished in record time: Physical maps are the key to accuracy
9. Research Bears Fruit, And Patents
10. Compounds From Fruits, Vegetables And Grains Slow The Growth Of Human Tumor Cells
11. Variations In The Human Homologue Of A Fruit Fly Gene Are Associated With Mood And Panic Disorders

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... 2017 According to a new market research report ... Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region ... expected to grow from USD 14.30 Billion in 2017 to USD 31.75 ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... , April 11, 2017 NXT-ID, Inc. ... technology company, announces the appointment of independent Directors Mr. ... to its Board of Directors, furthering the company,s corporate governance ... Gino ... we look forward to their guidance and benefiting from their ...
(Date:4/5/2017)... LONDON , April 4, 2017 KEY ... is anticipated to expand at a CAGR of 25.76% ... neurodegenerative diseases is the primary factor for the growth ... full report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The ... of product, technology, application, and geography. The stem cell ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... ... April 27, 2017 , ... Sierra Instruments announces ... capillary thermal mass flow technology provide exponentially more accurate mass flow data than ... of all industrial processes—such as those involving chemical reactions, combustion, respiration, pharmaceutical, and ...
(Date:4/27/2017)... WASHINGTON , April 27, 2017  Kinexum, a ... science products, today announces the appointment of Thomas ... G. Alexander ("Zan") Fleming, M.D., Kinexum founder, who becomes ... strategic advisor to Kinexum clients. Thomas ... take on the Kinexum mission and lead the firm,s ...
(Date:4/26/2017)... Baltimore, Maryland (PRWEB) , ... April 26, 2017 ... ... it will be demonstrating its new Bioflash MailGuardtm mail security screening solution at ... The Bioflash MailGuard system provides a fast, highly accurate, easy to ...
(Date:4/25/2017)... ... April 25, 2017 , ... Franz Inc ... (CL) development tools, and market leader for Semantic Graph Database technology, ... available within the most effective system for developing and deploying applications to solve ...
Breaking Biology Technology:
Cached News: