HOME >> BIOLOGY >> NEWS
Fruit flies unlock Methuselah's secrets

New research published in Genome Biology investigates genes that increase the life span of fruit flies in an effort to gain a greater understanding of the ageing process. The researchers from the University of Southern California and Harvard Medical School screened 10,000 fruit fly populations that were mutated. Their results revealed that six populations of mutant flies lived 5-17% longer than normal. Furthermore, analysis of these long-lived flies showed that the extended life span was caused by the overexpression of six different genes.

The use of the fruit fly Drosophila melanogaster in aging research is common as these flies are short-lived in comparison to humans but carry out many of the same biological processes. The current focus of research is on genes that increase the life span of an animal because it is difficult to disentangle changes that decrease life span from those that cause disease.

Jumping genes or transposable elements are regions of DNA that are able to move around the genome of an organism. The movement of these transposable elements can cause mutations because they interrupt a gene in another part of the genome. Gary Landis, Depak Bhole and John Tower exploited this phenomenon by using a chemically controlled transposable element that acts as an accelerator of gene expression to find mutations that could make flies live longer. Crucially, they were able to turn this acceleration on an off by feeding the flies a specific chemical and to look at the effects of the mutations in adult flies.

Their experiments revealed six fly populations that lived 5-17% longer than normal flies. Characterisation of these mutant flies showed increased expression of a different gene for each population. Interestingly the overexpressed genes were involved in a variety of fundamental cellular processes, which raises the possibility that similar effects are produced in higher organisms or even humans. The authors, however, are cautious a
'"/>

Contact: Gordon Fletcher
gordon@biomedcentral.com
44-20 7-323-0323
BioMed Central
30-Jan-2003


Page: 1 2

Related biology news :

1. Fruits offer powerful protection from skin cancer
2. Fruit odors lure some flies to evolve into new species
3. Fruit fly pheromone receptor first ever discovered linked to specific sexual behavior
4. Fruit consumption related to increased risk of Parkinsons?
5. Fruit fly cells reveal Hedgehogs secrets
6. Fruit fly model could explain how mosquitoes carry malaria: new drugs and vaccines on the horizon
7. Fruit flys genome sequence finished in record time: Physical maps are the key to accuracy
8. Research Bears Fruit, And Patents
9. Compounds From Fruits, Vegetables And Grains Slow The Growth Of Human Tumor Cells
10. Variations In The Human Homologue Of A Fruit Fly Gene Are Associated With Mood And Panic Disorders
11. Fruit-Fly Mating May Produce A Game Of Evolutionary Leapfrog

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... April 13, 2017 UBM,s Advanced Design and ... will feature emerging and evolving technology through its 3D ... will run alongside the expo portion of the event ... and demonstrations focused on trending topics within 3D printing ... and manufacturing event will take place June 13-15, 2017 at ...
(Date:4/11/2017)... -- Research and Markets has announced the addition of ... offering. ... market to grow at a CAGR of 30.37% during the period ... has been prepared based on an in-depth market analysis with inputs ... growth prospects over the coming years. The report also includes a ...
(Date:4/6/2017)... Forecasts by Product Type (EAC), ... End-Use (Transportation & Logistics, Government & Public Sector, Utilities ... Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), ... you looking for a definitive report on the $27.9bn ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia Inc ., ... a Webinar titled, “Pathology is going digital. Is your lab ready?” with Dr. ... best practices and how Proscia improves lab economics and realizes an increase in ...
(Date:10/11/2017)... LAGUNA HILLS, Calif. , Oct. 11, 2017 /PRNewswire/ ... London (ICR) and University of ... tool to risk-stratify patients with multiple myeloma (MM), in a ... . The University of Leeds is ... Myeloma UK, and ICR will perform the testing services to ...
(Date:10/11/2017)... ... October 11, 2017 , ... A new ... rates in frozen and fresh in vitro fertilization (IVF) transfer cycles. ... to IVF success. , After comparing the results from the fresh and frozen ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
Breaking Biology Technology:
Cached News: