HOME >> BIOLOGY >> NEWS
Fruit fly cells reveal Hedgehog's secrets

A Johns Hopkins-led research team has successfully used a technique to rapidly find fruit fly genes involved in a cell signaling pathway called Hedgehog, which is critical to proper embryo development and a key trigger in some cancers, including the deadly childhood brain cancer medulloblastoma.

By using the technique, called RNA interference, to "knock down" the messages of specific genes in fruit fly cells, researchers from Johns Hopkins and the National Institutes of Health screened 43 percent of the fruit fly's genes and found four new players involved in passing along Hedgehog's signal.

Reporting in the March 28 issue of Science, the scientists also suggest that the human counterparts of the fruit fly genes may be involved in birth defects and cancers characteristic of abnormal Hedgehog activity.

"Thanks to the human genome draft, we can make fairly direct connections between what we find in fruit flies and human disease," says Phil Beachy, Ph.D., a Howard Hughes Medical Institute investigator and a professor of molecular biology and genetics in Johns Hopkins' Institute for Basic Biomedical Sciences. "Our evidence suggests that human versions of these genes may be involved in disease, acting through the Hedgehog pathway."

In developing embryos of many organisms, including fruit flies, mice and humans, the Hedgehog signal ensures appropriate patterns of key proteins and cell types. Without the signal, these early developmental steps are disrupted, and severe -- usually fatal -- birth defects result. In some cancers, unnecessary activity of Hedgehog causes excessive cell growth. Understanding Hedgehog's signal one day may help prevent or correct these situations, say the researchers.

The Hedgehog pathway starts with a protein by the same name and ends with another protein that directly regulates the activity of a host of genes. A few key intermediate player
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
28-Mar-2003


Page: 1 2 3

Related biology news :

1. Fruits offer powerful protection from skin cancer
2. Fruit odors lure some flies to evolve into new species
3. Fruit fly pheromone receptor first ever discovered linked to specific sexual behavior
4. Fruit consumption related to increased risk of Parkinsons?
5. Fruit flies unlock Methuselahs secrets
6. Fruit fly model could explain how mosquitoes carry malaria: new drugs and vaccines on the horizon
7. Fruit flys genome sequence finished in record time: Physical maps are the key to accuracy
8. Research Bears Fruit, And Patents
9. Compounds From Fruits, Vegetables And Grains Slow The Growth Of Human Tumor Cells
10. Variations In The Human Homologue Of A Fruit Fly Gene Are Associated With Mood And Panic Disorders
11. Fruit-Fly Mating May Produce A Game Of Evolutionary Leapfrog

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/8/2019)... ROSKILDE, Denmark and RALEIGH, N.C. (PRWEB) , ... ... ... leader in micro acoustic and micro mechanical technologies and solutions for hearing instruments ... sensor technology, today announced BiometRIC, the first ever hearing aid receiver in canal ...
(Date:1/4/2019)... ... January 02, 2019 , ... Lifecycle Biotechnologies announces ... life science tools and service supplier turned 40 in 2018 and for the ... features not just part numbers like most catalogs, but rather, insightful information into ...
(Date:12/27/2018)... FRANCISCO (PRWEB) , ... December 27, 2018 , ... ... annual Microbiome Conference at JPM as part of the JP Morgan 37th Annual ... innovative scientists and physicians, and members of the investment community. , Since ...
Breaking Biology News(10 mins):
(Date:12/10/2018)... ... December 10, 2018 , ... ... Contract Development and Manufacturing Organization (CDMO) with sites in China and the ... manufacturing, and aseptic fill finish solutions for monoclonal antibody (mAb) and antibody-drug ...
(Date:12/5/2018)... ... ... The incredible life story of former refugee and LG Sonic CEO Yousef ... the European Commissioner for Research and Innovation. , In his November 27th speech ... spoke at length of Yousef’s life and journey, citing the man who convinced him ...
(Date:12/5/2018)... Va. and LONDON (PRWEB) , ... ... ... Research Group (ARG), an established North American full-service contract research organization (CRO), ... Effective immediately, the transaction significantly strengthens ARG’s reach and experience in the ...
(Date:11/28/2018)... ... November 28, 2018 , ... Earlier this month, Lajollacooks4u's ... as well as experience the height of truffle season. , Her first ... pristine countryside. Staying in the exclusive Black Truffle Lodge in the small mountain village ...
Breaking Biology Technology:
Cached News: