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Fugu fish sequencing project potential boon to gene hunters

n strategy" used so successfully by JGI researchers to complete the draft sequences of human chromosomes 5, 16 and 19. To speed the process even faster for the Fugu genome, researchers will use customized software now being developed at the JGI under the direction of Rokhsar. JGI scientists anticipate having more than 95-percent of the Fugu genome sequence available in an accessible database by March 2001.

The other members of the consortium will be responsible for the finishing phase of the project as well as contributing to the computational analysis of the genomic data. The long-term goal of this consortium is to generate complete sequence coverage of the Fugu genome and assemble it into a finished form for comparative genomic analysis.

Nobel laureate James Watson, co-discoverer of DNA's double helix structure, has endorsed this project. "The Fugu fish sequence, in combination with the draft mouse genome, to be available in early 2001, will greatly add to the comparative sequence studies that are now required to isolate coding and non-coding conserved elements within the human genome." Said Sydney Brenner, whose pioneering studies of Fugu biology with Greg Elgar and his colleagues in Singapore helped show that the organization of Fugu genes parallels that of human genes, "I am delighted that DOE has decided to sequence Fugu. The data will greatly enhance the identification of gene promoter regions and lead to a much better understanding of the human genome."


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Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
25-Oct-2000


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