HOME >> BIOLOGY >> NEWS
Functional genomics enables easy target identification and drives drug discovery

Palo Alto, Calif. May 10, 2004 Functional genomics and proteomics have been quite successful in identifying functions of potential therapeutic targets such as encoded proteins. In fact, the possibilities of identifying more than 10,000 novel target antigens in the human genome may accelerate the discovery of new drugs and therapeutic molecules.

"As opposed to conventional sequence homology, functional genomics adds structure-based predictions to locate gene sequences with assigned and confirmed functions," explains Frost & Sullivan Industry Analyst Rajaram Sankaran. "It simultaneously sifts through well established targets to detect critical therapeutic targets."

Such structural information results in enriched annotations that improve the identification process and also provide a clear understanding of interactions between specific molecules and target proteins.

Additionally, functional genomics opens up the possibilities of genetically demarcating patients and predicting individual responses to drugs. This permits customized medications and dosages that improve treatment safety and efficacy in areas such as neuropsychiatry, cardiovascular medicine, endocrinology, and oncology.

The success of functional genomics is magnified when used in conjunction with combinatorial chemistry (combichem) where a molecular compound is introduced into a compound library to chemically interconvert. It follows a target driven approach wherein, molecular building blocks are designed to react together selectively and covalently.

With an increasing number of new molecular entities (NMEs) entering clinical trials by 2008, a 65 percent increase in NMEs entering the market is expected innovative techniques for 'fast track' drug development and early screening of compounds are being devised.

One such technique gaining popularity is high-throughput screening (HTS) that detects and provides optimization guidelines for lead compounds and validate
'"/>

Contact: Julia Paulson
jpaulson@frost.com
210-247-3870
Technical Insights
10-May-2004


Page: 1 2

Related biology news :

1. Functional food Safety aspects
2. Moffitt Cancer Center receives DoD funds to establish National Functional Genomics Project
3. Anthrax genome may contain new clues to fight infection, says Science Functional Genomics article
4. Functional Arteries Grown From Cells Using Novel System That Simulates Fetal Environment
5. Structure Of Fat-Depleting Protein Reveals Important Functional Clues
6. Children With AD/HD Have Significant Functional Disabilities Related to Attention Deficit
7. International symposium on nutritional genomics
8. APS announces the winners of its 2004 postdoctoral fellowship in physiological genomics
9. Full promise of genomics in disease research yet to be realized
10. Pharmacogenomics could replace trial-and-error with science from the human genome
11. Dartmouth Medical School awarded $9 million grant for genomics research

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... MILAN , March 24, 2017 The Controller ... Deputy Controller Mr. Abdulla Algeen have received the prestigious international ... Continue Reading ... ... small picture) and Deputy Controller Abdulla Algeen (small picture on the right) ...
(Date:3/22/2017)... 21, 2017 Optimove , provider ... retailers such as 1-800-Flowers and AdoreMe, today announced ... and Replenishment. Using Optimove,s machine learning algorithms, these ... and replenishment recommendations to their customers based not ... of customer intent drawn from a complex web ...
(Date:3/13/2017)... , March 13, 2017 Future of security: Biometric Face ... ... DERMALOGs Face Matching enables to match face pictures against ... basis to identify individuals. (PRNewsFoto/Dermalog Identification Systems) ... DERMALOG,s "Face Matching" is the fastest software for biometric Face Matching ...
Breaking Biology News(10 mins):
(Date:4/21/2017)... ... April 21, 2017 , ... Frederick ... a range of emerging bio and technology start-ups, is hosting “Celebration Friday” (a ... double event will start with libations and networking at 3:30 p.m. at FITCI’s ...
(Date:4/20/2017)... , April 20, 2017  Eli Lilly and ... 2 data evaluating galcanezumab for the prevention of migraine ... which will take place April 22-28, 2017, in ... present four abstracts at AAN, including safety and patient ... factors associated with a reduction in monthly migraine headache ...
(Date:4/20/2017)... April 20, 2017 /PRNewswire/ - Prometic Life Sciences Inc. (TSX: PLI) ... at the International Liver Congress ("ILC") 2017 of the European ... Amsterdam on the positive effects of PBI-4050 ... of obesity and metabolic syndrome. ... According to Dr. Lyne Gagnon, Vice-President of R&D Pre-clinical ...
(Date:4/20/2017)... Dutch philosopher Koert van Mensvoort - founder of the Next Nature Network ... - has written a ,Letter to Humanity, in support of International ... a slave and victim to its own technology, but to employ technology to ... ... – founder of the Next Nature Network and Fellow of ‘Next Nature’ at ...
Breaking Biology Technology:
Cached News: