HOME >> BIOLOGY >> NEWS
Functional genomics enables easy target identification and drives drug discovery

Palo Alto, Calif. May 10, 2004 Functional genomics and proteomics have been quite successful in identifying functions of potential therapeutic targets such as encoded proteins. In fact, the possibilities of identifying more than 10,000 novel target antigens in the human genome may accelerate the discovery of new drugs and therapeutic molecules.

"As opposed to conventional sequence homology, functional genomics adds structure-based predictions to locate gene sequences with assigned and confirmed functions," explains Frost & Sullivan Industry Analyst Rajaram Sankaran. "It simultaneously sifts through well established targets to detect critical therapeutic targets."

Such structural information results in enriched annotations that improve the identification process and also provide a clear understanding of interactions between specific molecules and target proteins.

Additionally, functional genomics opens up the possibilities of genetically demarcating patients and predicting individual responses to drugs. This permits customized medications and dosages that improve treatment safety and efficacy in areas such as neuropsychiatry, cardiovascular medicine, endocrinology, and oncology.

The success of functional genomics is magnified when used in conjunction with combinatorial chemistry (combichem) where a molecular compound is introduced into a compound library to chemically interconvert. It follows a target driven approach wherein, molecular building blocks are designed to react together selectively and covalently.

With an increasing number of new molecular entities (NMEs) entering clinical trials by 2008, a 65 percent increase in NMEs entering the market is expected innovative techniques for 'fast track' drug development and early screening of compounds are being devised.

One such technique gaining popularity is high-throughput screening (HTS) that detects and provides optimization guidelines for lead compounds and validate
'"/>

Contact: Julia Paulson
jpaulson@frost.com
210-247-3870
Technical Insights
10-May-2004


Page: 1 2

Related biology news :

1. Functional food Safety aspects
2. Moffitt Cancer Center receives DoD funds to establish National Functional Genomics Project
3. Anthrax genome may contain new clues to fight infection, says Science Functional Genomics article
4. Functional Arteries Grown From Cells Using Novel System That Simulates Fetal Environment
5. Structure Of Fat-Depleting Protein Reveals Important Functional Clues
6. Children With AD/HD Have Significant Functional Disabilities Related to Attention Deficit
7. International symposium on nutritional genomics
8. APS announces the winners of its 2004 postdoctoral fellowship in physiological genomics
9. Full promise of genomics in disease research yet to be realized
10. Pharmacogenomics could replace trial-and-error with science from the human genome
11. Dartmouth Medical School awarded $9 million grant for genomics research

Post Your Comments:
(Date:7/29/2014)... New research from scientists at the University of Kent ... inside cells are regulated a breakthrough that could ... A team from Kent,s School of Biosciences uncovered the ... within cells known as actin filaments are ... these actin filaments appear to completely stable, providing a ...
(Date:7/29/2014)... breaking new book that brings together two of the ... the profile of insect fossils through stunning photographs and ... and James E Jepson, details the incredible preservation and ... the scene for what these remarkable fossils can tell ... the future of our planet. Like the mosquito in ...
(Date:7/28/2014)... U.S. Food and Drug Administration (FDA) for other purposes ... inside human cells, including those that cause Legionnaires, disease, ... mBio , the online open-access journal of the ... identifying non-antibiotic drugs that could one day help curb ... the list inhibit the growth of at least three ...
Breaking Biology News(10 mins):Unique images bring fossil insects back to life 2New route to identify drugs that can fight bacterial infections 2
(Date:7/29/2014)... (PRWEB) July 29, 2014 TransVac Solutions, ... linen collection and transport solutions for hospitals, will be ... Healthcare Engineering (ASHE) Annual Conference & Technical Exhibition Aug. ... present its technology for making hospitals cleaner, reducing infection ... over the hospital’s life cycle. Staff will be ...
(Date:7/29/2014)... Philadelphia’s newest entrepreneurial incubation space is ready ... The Innovation Center @3401 , a collaborative effort of ... Center to help attract and nurture start-up businesses in ... , The Innovation Center @3401 (ic@3401), which ... is the new home of DreamIt Ventures and ...
(Date:7/29/2014)... July 29, 2014  Sigma-Aldrich Corporation (NASDAQ: ... use, increased its investment in Green Chemistry and donated ... world last year, the Company announced Monday in its ... Changed the World? The report comes ... for being a responsible corporate citizen, including recognition for ...
(Date:7/29/2014)... July 29, 2014 Quorum Review ... has been awarded accreditation by the International ... its Lean Six Sigma Deployment Program. The citation ... improve performance. , Quorum’s Lean Six Sigma program ... Deployment Program designation. The designation is a public ...
Breaking Biology Technology:TransVac Presents Cost Saving Technology at ASHE Conference for Keeping Hospitals Cleaner 2Innovation Center @3401 Opens for Business; DreamIt Ventures and Point.io First Residents 2Innovation Center @3401 Opens for Business; DreamIt Ventures and Point.io First Residents 3Sigma-Aldrich Achieves Record Success in Environmental, Community Initiatives 2Sigma-Aldrich Achieves Record Success in Environmental, Community Initiatives 3Quorum Review IRB Accredited by IASSC for Lean Six Sigma Deployment Program 2Quorum Review IRB Accredited by IASSC for Lean Six Sigma Deployment Program 3
Cached News: