HOME >> BIOLOGY >> NEWS
Functional genomics enables easy target identification and drives drug discovery

Palo Alto, Calif. May 10, 2004 Functional genomics and proteomics have been quite successful in identifying functions of potential therapeutic targets such as encoded proteins. In fact, the possibilities of identifying more than 10,000 novel target antigens in the human genome may accelerate the discovery of new drugs and therapeutic molecules.

"As opposed to conventional sequence homology, functional genomics adds structure-based predictions to locate gene sequences with assigned and confirmed functions," explains Frost & Sullivan Industry Analyst Rajaram Sankaran. "It simultaneously sifts through well established targets to detect critical therapeutic targets."

Such structural information results in enriched annotations that improve the identification process and also provide a clear understanding of interactions between specific molecules and target proteins.

Additionally, functional genomics opens up the possibilities of genetically demarcating patients and predicting individual responses to drugs. This permits customized medications and dosages that improve treatment safety and efficacy in areas such as neuropsychiatry, cardiovascular medicine, endocrinology, and oncology.

The success of functional genomics is magnified when used in conjunction with combinatorial chemistry (combichem) where a molecular compound is introduced into a compound library to chemically interconvert. It follows a target driven approach wherein, molecular building blocks are designed to react together selectively and covalently.

With an increasing number of new molecular entities (NMEs) entering clinical trials by 2008, a 65 percent increase in NMEs entering the market is expected innovative techniques for 'fast track' drug development and early screening of compounds are being devised.

One such technique gaining popularity is high-throughput screening (HTS) that detects and provides optimization guidelines for lead compounds and validate
'"/>

Contact: Julia Paulson
jpaulson@frost.com
210-247-3870
Technical Insights
10-May-2004


Page: 1 2

Related biology news :

1. Functional food Safety aspects
2. Moffitt Cancer Center receives DoD funds to establish National Functional Genomics Project
3. Anthrax genome may contain new clues to fight infection, says Science Functional Genomics article
4. Functional Arteries Grown From Cells Using Novel System That Simulates Fetal Environment
5. Structure Of Fat-Depleting Protein Reveals Important Functional Clues
6. Children With AD/HD Have Significant Functional Disabilities Related to Attention Deficit
7. International symposium on nutritional genomics
8. APS announces the winners of its 2004 postdoctoral fellowship in physiological genomics
9. Full promise of genomics in disease research yet to be realized
10. Pharmacogenomics could replace trial-and-error with science from the human genome
11. Dartmouth Medical School awarded $9 million grant for genomics research

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/6/2016)... -- Valencell , the leading innovator in performance ... third consecutive year of triple digit growth for its ... a 360 percent increase in companies who have acquired ... by sales of its wrist and ear Benchmark™ sensor ... for hearables for fitness and healthcare applications. ...
(Date:12/2/2016)... 1, 2016 The report "Biometric ... Future Technology (Iris Recognition System), Vehicle Type (Passenger ... Forecast to 2021", published by MarketsandMarkets, the market ... 2016, and is projected to grow to USD ... 14.06%.      (Logo: http://photos.prnewswire.com/prnh/20160303/792302) ...
(Date:11/30/2016)... -- higi SH llc (higi) announced today the launch ... industry thought-leaders and celebrity influencers looking to encourage, ... steps to live healthier, more active lives. ... built the largest self-screening health station network in ... have conducted over 185 million biometric screenings.  The ...
Breaking Biology News(10 mins):
(Date:12/6/2016)... and SAN DIEGO , Dec. ... the appointment of Santosh Kesari , MD, PhD, ... will leverage his experience in neurology and clinical trials ... stem cell for treatment of stroke. The AmnioStem product is ... which has previously shown therapeutic activity in animal models ...
(Date:12/6/2016)... , Dec. 6, 2016  SRI International has ... million from the National Institutes of Health,s National ... Division of AIDS (NIAID-DAIDS) to support the manufacturing ... pre-exposure (PreP) agents. Under the seven-year contract, SRI ... development services for candidate HIV-prevention products that emerge ...
(Date:12/6/2016)... ... December 06, 2016 , ... ... company focused on discovery and development of precision treatments for neurodegenerative diseases, ... for Alzheimer’s disease (AD) inhibited the direct neurotoxic effect of prion-like forms ...
(Date:12/5/2016)... Dec. 5, 2016 Axovant Sciences Ltd. (NYSE: ... focused on the treatment of dementia, today announced that ... treatment of Alzheimer,s disease will be presented at the ... Friday, December 9, 2016 in San Diego ... of both simple and complex measures of activities of ...
Breaking Biology Technology:
Cached News: