HOME >> BIOLOGY >> NEWS
Functional genomics enables easy target identification and drives drug discovery

Palo Alto, Calif. May 10, 2004 Functional genomics and proteomics have been quite successful in identifying functions of potential therapeutic targets such as encoded proteins. In fact, the possibilities of identifying more than 10,000 novel target antigens in the human genome may accelerate the discovery of new drugs and therapeutic molecules.

"As opposed to conventional sequence homology, functional genomics adds structure-based predictions to locate gene sequences with assigned and confirmed functions," explains Frost & Sullivan Industry Analyst Rajaram Sankaran. "It simultaneously sifts through well established targets to detect critical therapeutic targets."

Such structural information results in enriched annotations that improve the identification process and also provide a clear understanding of interactions between specific molecules and target proteins.

Additionally, functional genomics opens up the possibilities of genetically demarcating patients and predicting individual responses to drugs. This permits customized medications and dosages that improve treatment safety and efficacy in areas such as neuropsychiatry, cardiovascular medicine, endocrinology, and oncology.

The success of functional genomics is magnified when used in conjunction with combinatorial chemistry (combichem) where a molecular compound is introduced into a compound library to chemically interconvert. It follows a target driven approach wherein, molecular building blocks are designed to react together selectively and covalently.

With an increasing number of new molecular entities (NMEs) entering clinical trials by 2008, a 65 percent increase in NMEs entering the market is expected innovative techniques for 'fast track' drug development and early screening of compounds are being devised.

One such technique gaining popularity is high-throughput screening (HTS) that detects and provides optimization guidelines for lead compounds and validate
'"/>

Contact: Julia Paulson
jpaulson@frost.com
210-247-3870
Technical Insights
10-May-2004


Page: 1 2

Related biology news :

1. Functional food Safety aspects
2. Moffitt Cancer Center receives DoD funds to establish National Functional Genomics Project
3. Anthrax genome may contain new clues to fight infection, says Science Functional Genomics article
4. Functional Arteries Grown From Cells Using Novel System That Simulates Fetal Environment
5. Structure Of Fat-Depleting Protein Reveals Important Functional Clues
6. Children With AD/HD Have Significant Functional Disabilities Related to Attention Deficit
7. International symposium on nutritional genomics
8. APS announces the winners of its 2004 postdoctoral fellowship in physiological genomics
9. Full promise of genomics in disease research yet to be realized
10. Pharmacogenomics could replace trial-and-error with science from the human genome
11. Dartmouth Medical School awarded $9 million grant for genomics research

Post Your Comments:
(Date:1/22/2015)... YORK , Jan. 21, 2015  Analyst Report Issued by ... Card Brands report showed that planet-wide, transactions at merchants on ... while the total number of credit, debit, and prepaid cards ... U.S. were victims of fraudulent card usage in 2012, and ...
(Date:12/24/2014)... , Dec. 23, 2014  Since its launch in December 2014, ... to eliminate the pain of trying to remember their usernames ... biometrics fused to their smartphones. To assist people who have ... the company that created 1U and focuses on redefining identity, ...
(Date:12/19/2014)... Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has announced the addition ... Systems Market" report to their offering. ... security market is estimated to grow at a CAGR of ... a larger share in this market, Canada ...
Breaking Biology News(10 mins):$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3
(Date:1/22/2015)... 22, 2015  Transwestern | RBJ today announces the firm brokered ... for Shire a leading biopharmaceutical company, at Two Ledgemont Center ... Robert Richards , president, and Brian Cohen , ... entire five-floor building at 95 Hayden Ave. Photo ...
(Date:1/22/2015)... Cambridge Semantics, the leading provider of smart data solutions driven ... record-breaking year across the board for the company. , ... and our Smart Data solutions, our customers were able to ... to record growth for the company in 2014,” said Alok ...
(Date:1/22/2015)... / Rootstown, OH (PRWEB) January 22, 2015 ... platform, announced today that it has received AOAC-PTM Certifications for ... O1O3, O111, O121, and O145; collectively referred to as STEC ... O157, at 1 colony forming unit (cfu) per 325 g ...
(Date:1/22/2015)... Dr. Greg Leyer of UAS Labs recently was invited ... seminar on probiotics in San Diego, CA. , The ... for health care professionals. This year’s pre-conference seminar was held ... health. Dr. Leyer spoke about the emerging topics and science ...
Breaking Biology Technology:Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Cambridge Semantics Announces Record Results for 2014 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2
Cached News: