GAD2 as a candidate gene for obesity

Like many complex physiological conditions, obesity results from the interaction of multiple genes and environmental factors. In a large case-control study of nuclear families in France, Philippe Froguel and colleagues used genome-wide scans of a chromosomal region linked with susceptibility to hone in on a new candidate gene for obesity. The same group had previously found strong linkage between a region of chromosome 10 and obesity. GAD2, one of the genes in the region, codes for an enzyme that catalyzes the production of a neurotransmitter in the hypothalamus that stimulates appetite, and is therefore an interesting candidate.

Screening genomic data on 575 obese subjects and 646 controls for different GAD2 alleles, Froguel and colleagues identified one group of alleles as "protective" against obesity and another as increasing risk. These findings were supported by genetic screens of the nuclear families participating in the study. And when the researchers investigated the physiological effect of the "highest risk" GAD2 variant in a mouse cell line, they found it caused a 6-fold increase in GAD2 transcript levels compared to the "wild-type" cells without the variant.

The researchers hypothesize that an overexpression of the GAD2 gene may increase the amount of the neurotransmitter GABA in the hypothalamus, thereby increasing GABA's orexigenic effects and leading to overeating. Studies in turkeys injected with muscimol, a GABA activator, and mice overexpressing a protein that regulates GABA localization support this notion; the more musimol the turkeys received, the more they ate, while the mice gained more weight and showed higher fat deposits.

Taken together, these results strongly suggest that genetic variations in GAD2 influence the risk for obesity. The researchers hope their work will inspire others to replicate their results, to confirm the genetic link and to elucidate the underlying biology of body weight control and eating behav

Contact: Barbara Cohen
Public Library of Science

Page: 1 2

Related biology news :

1. The search for a safer smallpox vaccine: New data released on promising candidate
2. ESA consults European science community on candidate Earth Explorer missions
3. VaxGen reports Phase I clinical trial results of anthrax vaccine candidate
4. Researchers identify candidate vaccine for Sjgren syndrome
5. Promising multi-strain HIV vaccine candidate emerges
6. Ten new candidate genes associated with salt sensitivity and hypertension are identified in rats
7. Adult human breast stem cell candidate found
8. Cyclin B1 identified as a new tumor antigen and candidate for the development of a cancer vaccine
9. Male infertility: Scientists discover candidate gene for impaired spermatogenesis
10. Researchers find candidate gene for premature menopause
11. Heart failure patients with worst heart function are good candidates for pacemakers

Post Your Comments:

(Date:6/25/2020)... ... June 24, 2020 , ... eClinical ... clinical data services that accelerate drug development, is collaborating with Karyopharm Therapeutics (Nasdaq: ... in hospitalized patients with severe COVID-19. This is the first study of an ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... healthcare, and Renovagen Ltd, a UK supplier and manufacturer of innovative portable renewable ... testing operations in the fight against the COVID-19 pandemic in Zambia. , One ...
(Date:6/23/2020)... Texas (PRWEB) , ... June 23, 2020 , ... ... analytical instrumentation, is pleased to announce the next event in a series of ... scattering. , The TOPIQ series of webinars was developed in response to social ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is now offering ... 50 million stem cells total, patients may choose which extremities they would like treated. ... joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is obtained from ...
(Date:7/31/2020)... ... July 29, 2020 , ... eSource has long been touted as ... cover the history of eSource, the reasons it did not take off as quickly ... site source, the industry is moving towards capturing data electronically for clinical trials and ...
(Date:7/18/2020)... ... July 16, 2020 , ... “We are thrilled to deliver this new ... only technology of its kind on the market and we were pleased that the ... capacity of traditional cultured ingredients, creating a natural way to extend the shelf life ...
(Date:7/10/2020)... ... July 09, 2020 , ... In most research ... to suppress pigment formation in zebrafish embryos, maintaining optical transparency to facilitate microscopic ... MA has been using the zebrafish model to investigate the causes of leukaemia ...
Breaking Biology Technology:
Cached News: