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Gel being developed to allow women to control fertility,reduce sexually-transmitted disease risk, including HIV, herpes

r final preclinical assessment and phase one clinical trials. A patent is pending on the product.

"Drs. Doncel and Stephen D. Bryant of Buckman Laboratory International of Memphis, Tenn., contributed substantially to the success of this research," says Gandour.

The Buckman Lab specializes in industrial microorganism control. "We don't produce human medicines or products, but we do screen many compounds," explains Bryant. "We screened compounds provided by Dr. Gandours group for microbial activity, specifically against Candida (yeast infections)." The lab is also looking for industrial applications for Z-15 and the other compounds provided by the Virginia Tech researchers, he said.

Co-authors on the ACS paper are Savle, now Chiral Product Specialist at Aldrich in Milwaukee, Gandour, Doncel, and Bryant. The ACS paper (MEDI paper 127) is about multi-gram synthesis of Z-15. It was presented Sunday evening, March 26 as part of the Division of Medicinal Chemistry poster session.


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Contact: Dr. Richard Gandour
gandour@vt.edu
540-231-3731
Virginia Tech
27-Mar-2000


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