HOME >> BIOLOGY >> NEWS
GenSAT (Gene Expression Nervous System Atlas) project announced

For scientists studying the brain, this week's Nature announces a remarkable new map describing previously uncharted territory, plus the means of exploring the new horizons for themselves. Rockefeller University scientists led by Nat Heintz, Ph.D., and Mary Beth Hatten, Ph.D., are well under way on a genetic atlas of the mammalian brain that provides unprecedented access to central nervous system regions, cell classes and pathways.

"Researchers studying degenerative and developmental diseases from Parkinson's and Huntington's to autism and epilepsy now will have genetic access to the brain without all the effort required of doing their own molecular genetics from scratch," says Heintz. "Gensat will advance the experimentation that can be done based on the information provided in the atlas; to me this is the key contribution of our project."

The project, called Gensat (Gene Expression Nervous System Atlas) employs a method for manipulation of "bacterial artificial chromosomes" or BACs, developed by project co-leader Heintz, professor and head of the Laboratory of Molecular Biology at Rockefeller and an investigator at the Howard Hughes Medical Institute. BACs in an early form provided the backbone of The Human Genome Project; Heintz discovered how to manipulate them by inserting, changing or deleting parts of the large gene sequences composing them. Once created, the modified BACs for individual genes are inserted into the genome of laboratory mice to assess gene expression.

The BAC technology provides unparalleled insight because it identifies the actual cell types in the brain in which individual genes express themselves. Heintz also added a reporter gene to the BACs so that cells with the selected gene activity glow bright green. Many new brain cell types or subtypes have been discovered in this project as a result of the potent tool. (Traditional methods of genetic analysis such as in situ hybridization cannot distinguish among cell types
'"/>

Contact: Lynn Love
lovel@rockefeller.edu
212-327-8977
Rockefeller University
29-Oct-2003


Page: 1 2 3 4

Related biology news :

1. Expression of Rb2/p130 and VEGF could serve as potential liver cancer prognosticators
2. 4th Annual Northwest Gene Expression Conference
3. Recombinant Protein Expression Lab established at CU
4. Researchers Find Unexpected Feature In Plankton Nervous System
5. New Class Of Molecular Cues Guides Nervous System Wiring
6. Brief Exposure To High Temperature Has Lasting Effect On Nervous System
7. Scientists Find First Protein In Central Nervous System Junctions
8. Sex-Specific Behavior Controlled By Peripheral Nervous System
9. Spinal Cord Injury Treatment May Improve With New Findings On Nervous System Damage
10. Shuttle Missions "Neurolab" To Study Nervous System
11. Pinpoint Gene Control Holds Promise For Nervous System Studies

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/28/2020)... ... February 28, 2020 , ... Meridian Clinical Research ... Vaccine Industry Excellence (ViE) award for Best Clinical Trial Site. Meridian is also ... the Best Clinical Trial Network award. These nominations were the result of two voting ...
(Date:2/28/2020)... SCOTTSDALE, Ariz. (PRWEB) , ... February 27, 2020 , ... ... PDO Max. The first rate PDO thread lift products are not only ... the portfolio. , Non invasive thread lift procedures are increasing exponentially in popularity, as ...
(Date:2/26/2020)... Texas (PRWEB) , ... February 25, 2020 , ... Renowned ... is among the first practices in Texas to offer the FDA-approved, post-surgical, corrective Light ... LAL implants have been placed with excellent results. Dell Laser Consultants is also currently ...
Breaking Biology News(10 mins):
(Date:2/11/2020)... ... February 11, 2020 , ... ... to announce the successful results from a long-term follow-up clinical study of ... interspinous fixation device (INSPAN LLC). Unlike extension block design, the Inspan device ...
(Date:2/5/2020)... Conn. (PRWEB) , ... February 04, 2020 , ... ... develops tools for characterizing microbiome populations down to the strain level, has announced ... will sell Shoreline Biome’s microbiome kits and other products to companies and research ...
(Date:2/3/2020)... BUDAPEST, Hungary and CAMBRIDGE, Mass. (PRWEB) , ... ... ... headquartered in Budapest with US offices in Cambridge, MA, announce that OmniType, the ... Access Program (EAP) from today. OmniType is a best-in-class product featuring locus-multiplexing and ...
(Date:1/28/2020)... COLLEGE, Pa. (PRWEB) , ... January 28, 2020 ... ... line of Better Salivary Assay Kits . The new Salivary Total ... bioscience research. “By measuring total immunoglobulin G in saliva, researchers can extend the ...
Breaking Biology Technology:
Cached News: