HOME >> BIOLOGY >> NEWS
Gene-Altered Mice Boost Studies of Cardiomyopathy: Enables Research Into Causes And Treatment Of Heart Failure

University of Chicago cardiologists have created the first transgenic mouse that closely reproduces the clinical, anatomical and pathological features of dilated cardiomyopathy, allowing scientists an unprecedented opportunity to study the early changes associated with this fairly common disorder and to develop and test new therapies.

The finding is reported in the June 1 issue of the Journal of Clinical Investigation.

"This is a big step toward better understanding and better treatments for a prevalent and very deadly disease," said cardiologist Jeffrey Leiden, M.D., Ph.D., Frederick H. Rawson Professor of Medicine and Pathology at the University of Chicago and director of the study.

Dilated cardiomyopathy is an important cause of congestive heart failure, which affects more than four million Americans. Congestive heart failure is the most common cause of hospitalization for patients over the age of 65 and a leading cause of death.

In dilated cardiomyopathy the heart muscle expands and weakens -- ballooning out like an over-stretched rubber band -- until it can no longer pump blood efficiently. Patients complain of overwhelming fatigue, shortness of breath and chest pains. Lack of adequate circulation, in turn, can damage the lungs, liver, and other body systems.

Although cardiomyopathy has been associated with many possible triggers, such as viral infections or alcohol abuse, the cause is usually unknown. Idiopathic (of unknown cause) dilated cardiomyopathy (IDC), affects an estimated 36 out of every 100,000 people. Recent studies have shown that as many as 40 percent of those patients have a family history of the disorder, suggesting a

Contact: John Easton
jeaston@mcis.bsd.uchicago.edu
773-702-6241
University of Chicago Medical Center
1-Jun-1998


Page: 1 2 3 4

Related biology news :

1. Gene-Altered Mouse May Provide New Insights To Parkinsons Disease, Substance Abuse And Schizophrenia
2. Boost your brain power
3. Report: High Carbon Dioxide Boosts Duke Forest Growth By 25 Percent
4. Researchers Find Vaginal Bacteria Imbalance Might Boost AIDS Risk
5. Genetic Research Boosts Understanding Of Irons Path Through Body, Diseases Of Iron Metabolism
6. Genes Boost Rice Yields On Poorest Farms
7. Cells From Mother Can Boost Success Of Sibling-To-Sibling Kidney Transplants
8. Scientists Locate A Genetic On/Off Switch In Diphtheria; Find May Yield Antibiotics That Wont Boost Bacterial Resistance
9. Open-Air Experiment Shows High CO2 Boosts Tree Growth
10. Boosting Immune Response Against HIV-1 Key To Controlling Infection, Say University Of Pittsburgh Researchers
11. Duke Researchers Finds That Moderate Caffeine Use Boosts Blood Pressure, Potential For Heart Disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/16/2019)... , ... April 16, 2019 , ... ... featured speakers for two signature events: The 2019 ISPE Biopharmaceutical Manufacturing Conference ... on 20–21 June. Taking place in one of the most influential bio hubs, ...
(Date:4/12/2019)... ... April 12, 2019 , ... Gnubiotics ... complex microbiota accessible carbohydrates (MACs) as specialty ingredients for the global animal and ... Register and commercial launch of its first-in class microbiome modulating prebiotic GNU100, for ...
(Date:4/5/2019)... ... April 04, 2019 , ... PI’s ... providing 0.05 microns and 0.005 microns resolution, respectively. The new design allows for ... available, from fast DC-servo motors with linear encoders and low-friction ball-screws to simple ...
Breaking Biology News(10 mins):
(Date:4/8/2019)... ... April 08, 2019 , ... CallTower, a ... the launch of their app integration solution, CT Cloud Unite. CT Cloud ... while using CT Cloud Voice and Skype for Business solutions. This robust integration ...
(Date:3/29/2019)... MOUNTAIN VIEW, Calif. (PRWEB) , ... March 28, ... ... the achievement of development and testing milestones, CARB-X has proceeded with a second ... will receive up to $1.7 million, which is on top of the $1.7 ...
(Date:3/23/2019)... ... March 22, 2019 , ... Tosoh ... Light Scattering (MALS) detector , offering a revolutionary approach for the measurement of ... and biopolymers. A novel optical design, a unique cell-block assembly, and a new ...
(Date:3/19/2019)... ... ... will review strategies for data management in modular and adaptive clinical trials. , Participants will:, ... 30 percent, reducing cost while increasing quality, achieving clinical site set-up faster , ... reducing risk and impact on trial success, trial teams, and trial execution , ...
Breaking Biology Technology:
Cached News: