HOME >> BIOLOGY >> NEWS
Gene-Altered Mice Boost Studies of Cardiomyopathy: Enables Research Into Causes And Treatment Of Heart Failure

University of Chicago cardiologists have created the first transgenic mouse that closely reproduces the clinical, anatomical and pathological features of dilated cardiomyopathy, allowing scientists an unprecedented opportunity to study the early changes associated with this fairly common disorder and to develop and test new therapies.

The finding is reported in the June 1 issue of the Journal of Clinical Investigation.

"This is a big step toward better understanding and better treatments for a prevalent and very deadly disease," said cardiologist Jeffrey Leiden, M.D., Ph.D., Frederick H. Rawson Professor of Medicine and Pathology at the University of Chicago and director of the study.

Dilated cardiomyopathy is an important cause of congestive heart failure, which affects more than four million Americans. Congestive heart failure is the most common cause of hospitalization for patients over the age of 65 and a leading cause of death.

In dilated cardiomyopathy the heart muscle expands and weakens -- ballooning out like an over-stretched rubber band -- until it can no longer pump blood efficiently. Patients complain of overwhelming fatigue, shortness of breath and chest pains. Lack of adequate circulation, in turn, can damage the lungs, liver, and other body systems.

Although cardiomyopathy has been associated with many possible triggers, such as viral infections or alcohol abuse, the cause is usually unknown. Idiopathic (of unknown cause) dilated cardiomyopathy (IDC), affects an estimated 36 out of every 100,000 people. Recent studies have shown that as many as 40 percent of those patients have a family history of the disorder, suggesting a

Contact: John Easton
jeaston@mcis.bsd.uchicago.edu
773-702-6241
University of Chicago Medical Center
1-Jun-1998


Page: 1 2 3 4

Related biology news :

1. Gene-Altered Mouse May Provide New Insights To Parkinsons Disease, Substance Abuse And Schizophrenia
2. Boost your brain power
3. Report: High Carbon Dioxide Boosts Duke Forest Growth By 25 Percent
4. Researchers Find Vaginal Bacteria Imbalance Might Boost AIDS Risk
5. Genetic Research Boosts Understanding Of Irons Path Through Body, Diseases Of Iron Metabolism
6. Genes Boost Rice Yields On Poorest Farms
7. Cells From Mother Can Boost Success Of Sibling-To-Sibling Kidney Transplants
8. Scientists Locate A Genetic On/Off Switch In Diphtheria; Find May Yield Antibiotics That Wont Boost Bacterial Resistance
9. Open-Air Experiment Shows High CO2 Boosts Tree Growth
10. Boosting Immune Response Against HIV-1 Key To Controlling Infection, Say University Of Pittsburgh Researchers
11. Duke Researchers Finds That Moderate Caffeine Use Boosts Blood Pressure, Potential For Heart Disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2019)... N.J. (PRWEB) , ... January 16, 2019 , ... As ... service offering through the introduction of its own liver 3D cell culture models. In ... of its models, protocols and validation criteria so that any researcher can replicate these ...
(Date:1/14/2019)... ... January 14, 2019 , ... ... detect precancer and cancer cells in blood, will present new findings at the ... the fight against colorectal cancer. The results from this study show CellMax Life’s ...
(Date:1/8/2019)... TORONTO (PRWEB) , ... January 07, 2019 , ... Join ... Maven Ridge for a live webinar on Thursday, January 17, 2019 at ... and ongoing management of risk during the clinical trial process. Featured speakers will also ...
Breaking Biology News(10 mins):
(Date:2/2/2019)... ... 2019 , ... Stay on top of current hot topics through free webinars ... all webinars is free, so be sure to register today to save your place! ... to check out our upcoming webinars, or click below to learn more about each ...
(Date:1/30/2019)... ... January 29, 2019 , ... K&R Negotiations announced today that Mladen Kresic, CEO ... event titled: Six Ways to Shorten the Sales Cycle : Reduce Complexity and ... the BrightTALK network. , Negotiation expert Kresic will discuss the realities of today’s ...
(Date:1/30/2019)... , ... January 30, 2019 , ... ... of the international tasting 5StarWines to promote and give recognition to producers whose ... Wine Without Walls selection takes place in Verona, Italy, contemporaneously to the 5StarWines ...
(Date:1/24/2019)... ... 2019 , ... Outsourcing trials to contract research organizations (CRO) ... RFP creation and management generally requires manual effort. Additionally, each vendor organizes tasks ... challenges can ultimately lead to study start delays and change orders because tasks ...
Breaking Biology Technology:
Cached News: