Gene-Altered Mouse May Provide New Insights To Parkinson's Disease, Substance Abuse And Schizophrenia

nts to neutrotransmitter transporters as the most important determinant of the strength and duration of cellular communications in the nervous system."

Dr. Ralph Snyderman, chancellor for health affairs at Duke, said, "These findings represent a superb example of the way in which basic research in academic medical centers leads to practical benefit. This discovery may well change our understanding of the nature of addiction and lead to new treatments for psychiatric disorders and Parkinson's disease. It once again shows how our nation's commitment to research is needed to provide practical solutions for common health care problems."

Insights into the mechanism of amphetamine drugs derived from studying the "knockout" mice should yield new strategies for treating amphetamine addiction, Caron said.

"Much of what we know about dopamine's function comes from studies of drugs that tamper with the dopamine system," he said. Cocaine, for example, temporarily blocks the transporter from outside the cell, so the dopamine remains at high concentrations in the synapse and continues to stimulate adjacent neurons, producing cocaine's characteristic "high."

Amphetamines, by contrast, are believed to enter the neuron via both the transporter and directly through the cell membrane, where they burst dopamine vesicles inside the cell and promote the release of dopamine.

"What happens when amphetamines break dopamine vesicles has been a matter of some speculation, since it has never been directly tested,"said Jones, a post-doctoral fellow.

These studies provide the first direct demonstration that the dopamine transporter is absolutely required for amphetamine's releasing action on dopamine. Amphetamine appears to reverse the dopamine transporter pump so instead of pumping dopamine into the cell, it pumps dopamine out of the cell, Caron said.

In the knockout mice with no dopamine transporters, amphetamines can still get in

Contact: Karyn Hede George
Duke University

Page: 1 2 3 4 5 6

Related biology news :

1. Gene-Altered Mice Boost Studies of Cardiomyopathy: Enables Research Into Causes And Treatment Of Heart Failure
2. Half-million dollar landmark achieved for the Methuselah Mouse Prize
3. Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis
4. Mouse brain stem cells capable of converting into blood vessel cells
5. Mouse study yields clue to why liver is less prone to rejection, say Pitt researchers
6. Mouse embryonic germ cells and male gametes created in the lab
7. Mouse, stripped of a key gene, resists diabetes
8. Mouse model of schizophrenia could speed identification of new antipsychotic drugs
9. Mouse study identifies protective mechanism against alcohol-induced embryo toxicity
10. Mouse model offers new explanation for kidney disease and failure
11. Mouse study suggests mammoth evolutionary change

Post Your Comments:

(Date:3/3/2020)... (PRWEB) , ... March 03, 2020 , ... Amplify Surgical, ... with the dualX Expanding Interbody Fusion System. , The landmark case was ... After the case Dr. Najafi noted, “dualX has completely changed the game for ...
(Date:3/2/2020)... (PRWEB) , ... March 02, 2020 , ... Toronto-based clinical ... is soon opening its newest office location just 5 minutes south of Clarksburg on ... orchard on the property, called End of the Rainbow Orchard, and decided it would ...
(Date:3/2/2020)... ... March 02, 2020 , ... Nominations are now being accepted for the ... Security Industry Association (SIA) and SecureIDNews and co-presented with sponsors ... . The recipients of this year’s Women in Biometrics Awards will be honored at ...
Breaking Biology News(10 mins):
(Date:3/4/2020)... ... ... This month, Cognosante will make its annual appearance at the HIMSS Global ... emerging offerings that align with the HIMSS annual theme, “Be the Change.” , ... engaging. From Interoperability and HIE to Cloud Computing and ...
(Date:3/3/2020)... ... March 03, 2020 , ... Ideal ... the latest breast implant technology at the IMCAS Innovation Shark Tank 2020 in ... the dermatology, plastic surgery, and aesthetic science industries that promise to revolutionize medical ...
(Date:2/28/2020)... ... February 26, 2020 , ... ... a high-speed camera with a dedicated controller, thus simplifying setup, streamlining integration, and ... HS7 is the first of Fastec Imaging’s new HS Series cameras to be ...
(Date:2/21/2020)... TORONTO, Ontario (PRWEB) , ... February 20, 2020 , ... ... (3pm GMT/UK) join guest speakers from Synteract including Lisa Dilworth, BS, MS, ... a discussion about these challenges, with feasible strategies and solutions to support patients, sites ...
Breaking Biology Technology:
Cached News: