HOME >> BIOLOGY >> NEWS
Gene For Inherited Syndrome Is Possible New Tumor Suppressor

COLUMBUS, Ohio -- New research has found the gene responsible for a rare inherited disorder that can lead to cancer in many different organs. Unexpectedly, the work might also have uncovered a new category of tumor suppressor genes.

The disorder is Peutz-Jeghers syndrome (PJS). People who are born with it typically develop precancerous polyps in the intestines in their teen years or later, and have freckle-like spots on the lips, around the mouth, and on the fingers.

These individuals are also at a higher risk for a variety of cancers, including those of the intestine, breast, pancreas, testis, and ovary, said Albert de la Chapelle, director of the Human Cancer Genetics Program at Ohio State University's Comprehensive Cancer Center and a co-author of the study.

The research, published this month in the journal Nature, will likely lead to a test that can be used to unequivocally diagnosis individuals with PJS and detect family members who carry the gene.

In addition, it may lead to a better understanding of how some cancers happen. "The more difficult, but in many ways more interesting, part of this story relates to how changes in this gene lead to cancer," said de la Chapelle.

"This is the way things often go when you're looking for genes. You begin with a condition, and you have no idea what sort of a gene causes it. So you map the gene's location on a chromosome and clone it, and then you find out what it does. Quite often, the function of the gene is very surprising."

In this study, de la Chapelle was a member of a team of researchers who studied 12 individuals with PJS. By examining cells from polyps removed from a single patient, the researchers were able to map the location of the gene to one tip of chromosome 19 (more specifically, to the tip of the short arm of chromosome 19).

With the gene identified, further study revealed a number of mutations that disabled it.

A gene that leads to cancer when it is disabled is know
'"/>

Contact: Albert de la Chapelle
delachapelle-1@medctr.osu.edu
(614) 688-4781
Ohio State University
28-Jan-1998


Page: 1 2

Related biology news :

1. Inherited gene may place some at higher risk of post-traumatic injury seizures
2. Inherited deafness studies may affect genetic counseling
3. Seattle Researchers Zero In On Location Of Gene For Inherited Prostate Cancer; Gene Also Linked To Brain Cancer
4. Vulnerability To Compulsive Gambling Is Partly Inherited
5. New Form Of Inherited Dwarfism In Large Pakistani Family Caused By Genetic Mutation In A Pituitary Receptor
6. Inherited Depression Linked To Shortage Of Cells In Brain Region
7. Ribozymes To The Rescue: New UF Gene Therapy Shows Promise For Treatment Of Inherited Blindness
8. Aspirin Decreases Genetic Mutations Associated With Inherited Colon Cancer
9. UF Discovery Of Chicken Gene Mutation Aids Study Of Rare Inherited Eye Disease
10. Jefferson Researchers Use Gene Therapy To Treat Rare, Inherited Brain Disease
11. Columbia Researchers Identify Gene For Inherited Baldness

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/22/2017)... 21, 2017 Vigilant Solutions , a ... enforcement agencies, announced today the appointment of retired FBI ... public safety business development. Mr. Sheridan brings ... including a focus on the aviation transportation sector, to ... position, Mr. Sheridan served as the Aviation Liaison Agent ...
(Date:3/13/2017)... Future of security: Biometric Face Matching software  ... ... Matching enables to match face pictures against each other or against large databases. ... Systems) ... the fastest software for biometric Face Matching on the market. The speed is ...
(Date:3/7/2017)... , March 7, 2017   HireVue , ... top global companies identify the best talent, faster, today ... Chief Sales Officer (CSO) and Diana Kucer ... round out a seasoned executive team poised to drive continued ... building on a year of record bookings in 2017. ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... ... March 21, 2017 , ... Okyanos Cell Therapy has ... part of their live events series, “Stem Cell Therapy: The Next Phase in the ... the 2013 Stem Cell Research and Therapy Act, Okyanos maintains a mission ...
(Date:3/22/2017)... NY (PRWEB) , ... March 21, 2017 , ... The ... Summit (CMO Summit) to be held on May 10-11, 2017, at the Colonnade ... the country specifically for Chief Medical Officer peer-to-peer learning, benchmarking and support. , “The ...
(Date:3/22/2017)... ... 22, 2017 , ... March 22, 2017...Council for Agricultural Science and Technology, Ames, ... utilizes technological innovation in smart, sustainable ways. Humans depend on plants for food, feed, ... environmental stability. This paper is the first in a series that connects science and ...
(Date:3/22/2017)... , March 22, 2017   Invitae Corporation ... genetic information companies, today announced the availability of ... Spinal Muscular Atrophy (SMA) , a neuromuscular ... genetic disorders among infants as well as a ... The new test, announced during the American College ...
Breaking Biology Technology:
Cached News: