HOME >> BIOLOGY >> NEWS
Gene For Inherited Syndrome Is Possible New Tumor Suppressor

COLUMBUS, Ohio -- New research has found the gene responsible for a rare inherited disorder that can lead to cancer in many different organs. Unexpectedly, the work might also have uncovered a new category of tumor suppressor genes.

The disorder is Peutz-Jeghers syndrome (PJS). People who are born with it typically develop precancerous polyps in the intestines in their teen years or later, and have freckle-like spots on the lips, around the mouth, and on the fingers.

These individuals are also at a higher risk for a variety of cancers, including those of the intestine, breast, pancreas, testis, and ovary, said Albert de la Chapelle, director of the Human Cancer Genetics Program at Ohio State University's Comprehensive Cancer Center and a co-author of the study.

The research, published this month in the journal Nature, will likely lead to a test that can be used to unequivocally diagnosis individuals with PJS and detect family members who carry the gene.

In addition, it may lead to a better understanding of how some cancers happen. "The more difficult, but in many ways more interesting, part of this story relates to how changes in this gene lead to cancer," said de la Chapelle.

"This is the way things often go when you're looking for genes. You begin with a condition, and you have no idea what sort of a gene causes it. So you map the gene's location on a chromosome and clone it, and then you find out what it does. Quite often, the function of the gene is very surprising."

In this study, de la Chapelle was a member of a team of researchers who studied 12 individuals with PJS. By examining cells from polyps removed from a single patient, the researchers were able to map the location of the gene to one tip of chromosome 19 (more specifically, to the tip of the short arm of chromosome 19).

With the gene identified, further study revealed a number of mutations that disabled it.

A gene that leads to cancer when it is disabled is know
'"/>

Contact: Albert de la Chapelle
delachapelle-1@medctr.osu.edu
(614) 688-4781
Ohio State University
28-Jan-1998


Page: 1 2

Related biology news :

1. Inherited gene may place some at higher risk of post-traumatic injury seizures
2. Inherited deafness studies may affect genetic counseling
3. Seattle Researchers Zero In On Location Of Gene For Inherited Prostate Cancer; Gene Also Linked To Brain Cancer
4. Vulnerability To Compulsive Gambling Is Partly Inherited
5. New Form Of Inherited Dwarfism In Large Pakistani Family Caused By Genetic Mutation In A Pituitary Receptor
6. Inherited Depression Linked To Shortage Of Cells In Brain Region
7. Ribozymes To The Rescue: New UF Gene Therapy Shows Promise For Treatment Of Inherited Blindness
8. Aspirin Decreases Genetic Mutations Associated With Inherited Colon Cancer
9. UF Discovery Of Chicken Gene Mutation Aids Study Of Rare Inherited Eye Disease
10. Jefferson Researchers Use Gene Therapy To Treat Rare, Inherited Brain Disease
11. Columbia Researchers Identify Gene For Inherited Baldness

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2016)... Massachusetts , March 23, 2016 /PRNewswire/ ... im Interesse erhöhter Sicherheit Gesichts- und Stimmerkennung ... Xura, Inc. (NASDAQ: MESG ), ... bekannt, dass das Unternehmen mit SpeechPro zusammenarbeitet, ... aus der Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, ...
(Date:3/21/2016)... 22, 2016 Unique technology ... for superior security   Xura, ... of secure digital communications services, today announced it is ... offer enterprise customers, particularly those in the Financial Services ... voice authentication within a mobile app, alongside, and in ...
(Date:3/15/2016)... 15, 2016 --> ... Transparency Market Research "Digital Door Lock Systems Market - Global ... 2023," the global digital door lock systems market in terms ... and is forecast to grow at a CAGR of 31.8% ... and medium enterprises (MSMEs) across the world and high industrial ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... ... May 25, 2016 , ... Thailand’s ... at BIO 2016 in San Francisco. Located at booth number 7301, representatives from ... answer questions and discuss the Thai biotechnology and life sciences sector. , ...
(Date:5/25/2016)... ... 2016 , ... Scientists at the University of Athens say they have evidence ... hampering the research that could lead to one good one. Surviving Mesothelioma has just ... , The team evaluated 98 mesothelioma patients who got a second ...
(Date:5/24/2016)... ... 2016 , ... Cell therapies for a range of serious ... at Worcester Polytechnic Institute (WPI) that yielded a newly patented method of converting ... novel method, developed by WPI faculty members Raymond Page, PhD, professor of practice ...
(Date:5/23/2016)... ... 23, 2016 , ... The need for blood donations in South Texas and across the nation ... Blood & Tissue Center, blood donations are on the decline. In fact, donations across the ... 21 percent in South Texas in the last four years alone. , There is no ...
Breaking Biology Technology:
Cached News: