HOME >> BIOLOGY >> NEWS
Gene Influences How Lifestyle Affects Blood Cholesterol

DALLAS, Nov. 10 -- A gene that influences blood cholesterol levels can also predict how much those levels are affected by weight gain, smoking and other lifestyle factors, according to a study presented today at the American Heart Association's 71st Scientific Sessions.

Sathanur R. Srinivasan, Ph.D., and colleagues at the Tulane Center for Cardiovascular Health, New Orleans, showed that the gene called apolipoprotein E, or (apo)E gene, is influenced from childhood to adulthood by environmental factors.

An adult's blood cholesterol level can be influenced by the (apo)E gene -- which is expressed in three forms, or alleles: E-2, E-3 and E-4.

One form, the E-2, is associated with low levels of cholesterol. Cholesterol is a fatty substance in the blood that collects in the walls of blood vessels. If the blood vessels to the heart become narrowed -- a process called atherosclerosis -- a heart attack can result.

However, a new study shows that weight gain and other risk factors for heart disease cause cholesterol levels to rise relatively more in people with the E-2 form of the gene when compared to those with other forms of the gene. "People with E-3 or E-4 still may have elevated cholesterol levels if they gain weight, but the changes in E-2 individuals are greater," says Srinivasan.

"The (apo)E gene influences not only cholesterol levels from childhood to adulthood, but also moderates how an individual's cholesterol levels may interact with the risk factors and behaviors that contribute to heart disease," says Srinivasan. "Although people with the E-2 variant have this beneficial cholesterol profile, smoking, obesity and other cardiovascular risk factors can negate this benefit.

"The study shows that if you know your (apo)E gene type, it is possible to determine your risk status for high cholesterol during life and how great your risk can be influenced by factors such as smoking and decreases or increases in body fat," says Srinivasan.


'"/>

Contact: Carole Bullock
caroleb@heart.org
214-706-1279
American Heart Association
10-Nov-1998


Page: 1 2

Related biology news :

1. Influences of sex on gene expression discussed at annual conference
2. Gene Influences Heart Disease And Stroke Risk Factors
3. Why some animals have smaller eyes: Lifestyle matters
4. Lifestyle accounts for difference in chimp, human genome
5. Lifestyle changes clinically effective
6. Lifestyle factors fuel high diabetes risk in African-American women
7. Lifestyle Determinants Of Plasma Homocysteine
8. Colon Cancer Linked To Genes, Not Lifestyle
9. Wake Forest Physicians Demonstrate How Gene-Diet Interaction Affects Cholesterol Absorption
10. Fetal Growth Rate Affects Risk Of Heart Disease
11. Not Just What You Eat That Affects Risk For Heart Disease And Stroke; Your Genes Influence How Much Damage High-Fat Diet Causes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/20/2018)... ... 20, 2018 , ... The Utah Department of Health (UDOH) has contracted with ... specimens across the state. The system will be deployed to all birthing hospitals ... screening laboratory in Salt Lake City. This supports UDOH’s goals of saving lives and ...
(Date:11/16/2018)... ... November 16, 2018 , ... ... awarded the International Bottled Water Association’s (IBWA’s) IBWA/Shayron Barnes-Selby Advocacy Award at the ... Award, named “The Selby” after longtime IBWA contributor Shayron Barnes-Selby, is awarded to ...
(Date:11/15/2018)... ... ... Firmex today released new research on merger and acquisition advisory fees prepared in conjunction ... to compile the third annual M&A Fee Guide 2018-19 report. Contributors BDO Canada ... Highlights in the 2018-19 Report:, , The latest data shows ...
Breaking Biology News(10 mins):
(Date:12/5/2018)... and LONDON (PRWEB) , ... ... ... Group (ARG), an established North American full-service contract research organization (CRO), announced ... immediately, the transaction significantly strengthens ARG’s reach and experience in the management ...
(Date:11/28/2018)... ... November 28, 2018 , ... Earlier this month, Lajollacooks4u's Founder and Chef Jodi ... the height of truffle season. , Her first stop was Umbria, a ... the exclusive Black Truffle Lodge in the small mountain village of Pettino, Chef Jodi ...
(Date:11/26/2018)... , ... November 26, 2018 , ... ... backed by Siemens Healthineers and Omphalos Venture Partners (Virtual Radiologic founders) among other ... Meeting from Nov. 25-29 at McCormick Place in Chicago. The company is proud ...
(Date:11/20/2018)... ... November 19, 2018 , ... Patients with missing teeth in Sandy Springs, GA, ... Dr. Dan Myers at THE DENTIST Centers without a referral. Dr. Myers is a ... last 20 years. He now offers skilled dental care in two practice locations THE ...
Breaking Biology Technology:
Cached News: