HOME >> BIOLOGY >> NEWS
Gene Therapy Enables Transplantation Without Immunosuppressive Drugs

Researchers at the University of Pennsylvania Medical Center, working in a rodent model, have succeeded in transplanting livers without the need for immunosuppressive drugs. In a scientific first, a gene therapy strategy was used to alter the donor liver prior to surgery so that the immune system of the recipient became permanently tolerant of the new organ. The new findings are reported in the February issue of Nature Medicine.

Although additional animal studies will be required before human clinical trials of the approach can be considered, the advantages of such a localized system for countering the immune-system rejection of newly engrafted organs are potentially significant. The powerful immunosuppressive drugs now required to allow a life-saving transplanted organ to survive in a recipient's body without rejection do their work only at a substantial cost to the overall well-being of the recipient.

"Currently, all immunosuppression is systemic and lifelong," says Kim M. Olthoff, MD, an assistant professor of surgery and lead author on the study. "So, to protect the new organ from rejection, long-term drugs that suppress the entire immune system must be given, making the person susceptible to infections, cancers, and a number of other complications, including nerve and kidney damage. In our study, a one-time gene therapy treatment of only the donor liver made the recipient's immune system tolerant of the new organ without the need for any further immunosuppression."

The technique developed by the Penn team makes use of an adenovirus -- a virus usually associated with the common cold -- that has been engineered to incorporate the gene that encodes for a protein called CTLA4Ig. The gene-bearing virus, referred to as a vector, is then introduced into an organ preservation solution used to maintain the liver after harvesting and prior to engraftment, resulting in uptake by the organ
'"/>

Contact: Franklin Hoke
hokef@mail.med.upenn.edu
215-349-5659
University of Pennsylvania School of Medicine
29-Jan-1998


Page: 1 2 3

Related biology news :

1. 1st International Conference on Cell Therapy for Cardiovascular Disease
2. National Cancer Gene Therapy Foundation gives $4.0 million in research grants
3. Braunschweig Prize 2003 for Molecular Cancer Therapy
4. Alliance for Cancer Gene Therapy announces $1.5 million in national grants to young investigators
5. New research on safety of intracoronary delivery of adenovector reported in cover story of Molecular Therapy
6. Therapy hinders AIDS virus from evolving drug resistance, Hopkins researchers find
7. Invitation To Cover: American Society Of Gene Therapy Meeting
8. Gene Therapy For Pain
9. Role Of Protein Linked To Colon Cancer Identified, Offering Potential Target For Therapy
10. Shock Therapy Exceeds Expectations In Cleaning Up Contaminated Soils
11. Penn Researchers Develop Gene Therapy Technique That Reverses Muscle Membrane Weakness In Muscular Dystrophy Variant

Post Your Comments:
(Date:8/25/2014)... the first U.S. outbreaks of the H1N1 virus swept ... people. A university math and biology professor has used ... gain insight into how only a few infected people ... community., The fall 2009 semester hadn,t even started when ... and Wellness Services clinic11 one day, and just two ...
(Date:8/25/2014)... battery-powered DNA diagnostic device invented at New Zealand,s ... commonly used field tool for rapidly detecting suspected ... the level of infection. , The breakthrough device, ... Queenstown Molecular Biology main meeting. It takes advantage ... target DNA sequences in real-time, without the need ...
(Date:8/25/2014)... separation from a device the size of a cell ... acoustic waves, according to a team of engineers., "For ... before analysis," said Tony Jun Huang, professor of engineering ... the integrity of the cells, damages them in any ... surface acoustic waves can separate cells using very small ...
Breaking Biology News(10 mins):WSU flu outbreak provides rare study material 2WSU flu outbreak provides rare study material 3Revolutionary handheld DNA diagnostic unit allows lab-quality analysis in the field 2Tilted acoustic tweezers separate cells gently 2
(Date:8/26/2014)... , Aug. 26, 2014  That,s Nice LLC, ... markets, today announced the formation of a new dedicated ... development. The expanded team will combine current and new ... at That,s Nice. Guy Tiene ... to lead the team. Tiene was previously Director of ...
(Date:8/26/2014)... InstantGMP, Inc., the only cloud-based manufacturing execution ... structure with increased user accounts to help current and ... Part 11 requirements. , “We want to help our ... said Rick Soltero, President of InstantGMP. “We found ... to have separate accounts for multiple quality managers and ...
(Date:8/26/2014)... August 26, 2014 Formedix, the ... announced the release of Transform for MARVIN: the ... Data Capture (EDC) product line. It was developed ... allows integration with MARVIN, the EDC and Clinical ... study setup time, by allowing instantaneous visualization of ...
(Date:8/26/2014)... 2014 /PRNewswire-iReach/ -- The crowdfunding campaign for PosturePulse ... on the popular crowdfunding platform Kickstarter. Backers have already ... biofeedback belt. The $75,000 funding goal for the campaign ... product. Photo - http://photos.prnewswire.com/prnh/20140825/139254 ... the lower back that silently vibrates if the wearer ...
Breaking Biology Technology:That's Nice Announces Expanded Offering For Strategic Content And Public Relations 2That's Nice Announces Expanded Offering For Strategic Content And Public Relations 3Introducing Transform for MARVIN: Providing Further Flexibility for CROs and Sponsors in Partnership with XClinical 2PosturePulse, A Biofeedback Posture-Improving Belt, Improves Posture While Sitting or Standing 2
Cached News: