HOME >> BIOLOGY >> NEWS
Gene Therapy For Pain

NIH scientists are attacking chronic pain with a novel form of gene therapy that targets the spinal cord. Though still in the animal testing stage, this approach has overcome one of the major obstacles to gene therapy as a way to manipulate spinal cord function. Rather than injecting genes directly into a localized area of the spinal cord, the pain-relieving gene is introduced into the sheath of tissue that surrounds the cord. From that strategic location, the gene can pump out its product and bathe many nerves, thus extending the range of its pain-numbing effect. The investigators hope that this simplified approach can be used to generate a variety of products in the tissue surrounding nerves, including factors that could stimulate new nerve growth.

The study, carried out by scientists from the National Institute of Dental and Craniofacial Research (NIDCR) and the University of Pennsylvania, was reported in the May 1 issue of Human Gene Therapy.

"We are totally pumped up that this approach is working in an animal model," said Dr. Mike Iadarola, chief of NIDCR's Neuronal Gene Expression Unit. "The animal studies have shown us that genes are readily taken up by the connective tissue cells that surround the central nervous system. So, given the right gene, our approach has application to a broad range conditions, from pain control to spinal cord injury and disorders like multiple sclerosis and Parkinson's disease."

In the study, investigators used an adenovirus--similar to a cold virus-- to deliver the beta-endorphin gene to the rat spinal cord. The virus particles were injected into the spinal fluid, where they were readily taken up by the protective sheath of connective tissue, called the pia mater, which surrounds the cord. Within 24 hours the sheath cells began secreting beta-endorphin, one of the body's natural sedatives for alleviating pain.

"The incredible simplicity and relative noninvasiveness of this approach provides a new fram
'"/>

Contact: Wayne Little
wayne.little@nih.gov
301-496-4261
NIH/National Institute of Dental and Craniofacial Research
1-May-1999


Page: 1 2 3

Related biology news :

1. 1st International Conference on Cell Therapy for Cardiovascular Disease
2. National Cancer Gene Therapy Foundation gives $4.0 million in research grants
3. Braunschweig Prize 2003 for Molecular Cancer Therapy
4. Alliance for Cancer Gene Therapy announces $1.5 million in national grants to young investigators
5. New research on safety of intracoronary delivery of adenovector reported in cover story of Molecular Therapy
6. Therapy hinders AIDS virus from evolving drug resistance, Hopkins researchers find
7. Invitation To Cover: American Society Of Gene Therapy Meeting
8. Role Of Protein Linked To Colon Cancer Identified, Offering Potential Target For Therapy
9. Shock Therapy Exceeds Expectations In Cleaning Up Contaminated Soils
10. Penn Researchers Develop Gene Therapy Technique That Reverses Muscle Membrane Weakness In Muscular Dystrophy Variant
11. University Of Pittsburgh Involved In First Successful Example Of Gene Therapy For Pain Control

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/6/2019)... (PRWEB) , ... August 05, 2019 , ... Keck Graduate ... KGI School of Pharmacy and Health Sciences (SPHS). , “Dean Zdanowicz is highly regarded ... of Trustees Chairman Jim Widergren. “He is a great choice to build on the ...
(Date:8/6/2019)... , ... August 06, 2019 , ... ... and environmental concerns. One plant-based food in particular quickly entered the limelight – ... product developers use a thermogelling and emulsifying ingredient such as methyl cellulose. This ...
(Date:8/4/2019)... PRINCETON, N.J. (PRWEB) , ... August 02, 2019 ... ... expertise to assist the life science industry in advancing the development of medical ... has been recognized by PharmaVOICE magazine as one of the “100 Most Inspiring ...
Breaking Biology News(10 mins):
(Date:8/14/2019)... ... 13, 2019 , ... INDIGO Biosciences, Inc. (INDIGO), the recognized ... appointment of Mark McLoughlin to the Company’s Board of Directors. Mark brings four ... his healthcare expertise and extensive background in laboratory and scientific products manufacturing, distribution, ...
(Date:8/6/2019)... ... August 06, 2019 , ... The San Diego Biotechnology ... the biweekly SDBN BUZZ podcast focused on connecting the region’s biotech community and ... to promote the region and attract external employers, investors, scientists, and others who ...
(Date:8/4/2019)... MINNEAPOLIS (PRWEB) , ... August 02, 2019 , ... Cirtec ... minimally invasive devices, today announced that it has begun construction on a 30,000 sq. ... about 15 miles from San Jose. , The facility, which is expected to ...
(Date:7/19/2019)... ... 2019 , ... Global precision motion and piezo technology solutions ... facilities in Lederhose, Germany, increasing their current footprint by half again. , The ... addition to general office space, a significant increase to its existing 129,000ft² structure. ...
Breaking Biology Technology:
Cached News: