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Gene Therapy In A Liquid May Lead To Quicker, Easier Methods For Treating,,Disease

Gene therapy's future may lie in swallowing a liquid. Scientists at Jefferson Medical College have successfully administered gene therapy orally, effectively curing lactose intolerance in rats. In proving that gene therapy may potentially be given this way, the work may eventually lead to treatments for important human diseases such as diabetes.

Neuroscientist Matthew During, M.D., professor of neurosurgery and director of the Central Nervous System Gene Therapy Center at Thomas Jefferson University in Philadelphia, and his colleagues put a gene for lactose intolerance inside a virus, and then into a liquid solution. When they gave the solution to laboratory rats, the gene began working in about 20 percent of the rats' proximal intestinal cells--enough, he says, to correct the experimentally induced lactose intolerance in the animals. The effect lasted four months, the length of the experiment.

He and his co-workers report their findings in the October issue of Nature Medicine.

Dr. During and his colleagues inserted a beta-galactosidase gene--which encodes for an enzyme that breaks down lactose--into an adeno-associated virus vector. They then gave this orally through a special tube to lactose-intolerant rats. The gene incorporated into the cells lining the rats' gastrointestinal tract, allowing them to break down lactose.

"We showed several important things," he says. "We could deliver a gene noninvasively, we could achieve long-term gene expression through a simple oral route, and there was enough gene expression to treat a disease such as lactose intolerance."

The work has potential applications for treating other diseases such as diabetes, he notes, "for which you want to deliver a protein into the circulation."

The researchers' goal wasn't necessarily to find a cure for lactose intolerance--rather, they used the disorder as a model. "We used lactose intolerance to help
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Contact: Steve Benowitz
steven.benowitz@mail.tju.edu
(215) 955-6300
Thomas Jefferson University
28-Sep-1998


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