HOME >> BIOLOGY >> NEWS
Gene Therapy Incorporates Molecular Rheostat For Controlled, Long-Term Drug Delivery

Using a unique combination of innovative technologies, scientists have demonstrated the ability to introduce therapeutic genes into the body and then, further, to precisely control the activity of those genes with a drug that could be given as a simple pill.

The novel gene therapy system, developed by researchers at the University of Pennsylvania Medical Center and ARIAD Pharmaceuticals in Cambridge, MA, represents an entirely new form of drug delivery, one that opens the door to many therapies not previously possible. A report on the experimental study, performed in mice and monkeys, will appear in the January 1, 1999, issue of Science. (Copies of the final version of the paper are available to reporters through the journal's news office at 202-326-6421.)

"We're excited about these results, because they create many new opportunities for experimental and then clinical applications of gene therapy that we couldn't consider before," says James M. Wilson, MD, PhD, director of the Institute for Human Gene Therapy at Penn and senior author on the report. "This system will allow us to modulate the expression of a delivered gene in response to changes in a patient's disease."

The new system couples advances at Penn allowing the long-term introduction of genes into the body with a patented technology (ARGENT) to regulate gene activity from ARIAD.

As the culmination of several years of concerted effort, Penn researchers recently succeeded in optimizing a gene therapy viral vector to achieve long-term protein production without sparking an immune-system reaction. The vector is an engineered version of a virus known as adeno-associated virus, or AAV, which is a very small, innocuous virus.

For this project, the Penn and ARIAD scientists stripped two AAVs of their viral genes and reloaded them respectively with the gene for erythropoietin, or Epo, a recombinant protein that stimulates red blood cell product
'"/>

Contact: Franklin Hoke
hokef@mail.med.upenn.edu
215-349-5659
University of Pennsylvania School of Medicine
1-Jan-1999


Page: 1 2 3

Related biology news :

1. 1st International Conference on Cell Therapy for Cardiovascular Disease
2. National Cancer Gene Therapy Foundation gives $4.0 million in research grants
3. Braunschweig Prize 2003 for Molecular Cancer Therapy
4. Alliance for Cancer Gene Therapy announces $1.5 million in national grants to young investigators
5. New research on safety of intracoronary delivery of adenovector reported in cover story of Molecular Therapy
6. Therapy hinders AIDS virus from evolving drug resistance, Hopkins researchers find
7. Invitation To Cover: American Society Of Gene Therapy Meeting
8. Gene Therapy For Pain
9. Role Of Protein Linked To Colon Cancer Identified, Offering Potential Target For Therapy
10. Shock Therapy Exceeds Expectations In Cleaning Up Contaminated Soils
11. Penn Researchers Develop Gene Therapy Technique That Reverses Muscle Membrane Weakness In Muscular Dystrophy Variant

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/4/2020)... (PRWEB) , ... July 03, 2020 , ... ... proud to earn outstanding recognition and multiple awards for not only the products ... ABM portfolio, SoME® Skincare and Vivace® Microneedle RF. All the brands built by ...
(Date:7/1/2020)... ... July 01, 2020 , ... Catalent, ... the purchase of Teva-Takeda Pharmaceuticals’ packaging facility in Minakuchi, located in the Shiga ... supply facility located in Kakegawa, the new 60,000-square-foot facility will provide customers with ...
(Date:6/28/2020)... Fla. (PRWEB) , ... June 25, 2020 , ... In ... focus on innovations in accelerated Point of Care Testing solutions (POCT). Check local listings ... Samples are collected at medical offices and are shipped to labs throughout the country. ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... ... 2020 , ... dicentra , a leading Contract Research ... is pleased to announce that Charles Galea has joined its clinical trials division ... an accomplished and results-driven sales executive with over 10 years of expertise in ...
(Date:7/10/2020)... ... July 09, 2020 , ... In most ... used to suppress pigment formation in zebrafish embryos, maintaining optical transparency to facilitate ... Dr MA has been using the zebrafish model to investigate the causes of ...
(Date:7/7/2020)... , ... July 06, 2020 , ... ... Awards. Entries from Roche, Eli Lilly, Bristol-Myers Squibb, the University of Chicago, Massachusetts ... Bio-IT World has hosted an elite awards program, highlighting outstanding examples of how ...
(Date:7/1/2020)... ... June 30, 2020 , ... ... the launch of a new clinical diagnostics immuno-oncology service, TissueInsight . ... (TME). , “Flagship’s TissueInsight is a service that aids pathologists, oncologists, and ...
Breaking Biology Technology:
Cached News: