HOME >> BIOLOGY >> NEWS
Gene alteration points to longevity, thinness

Imagine that by altering the function of a single gene, you could live longer, be thinner and have lower cholesterol and fat levels in your blood.

Medical College of Georgia researchers are using a tiny worm called C. elegans to transform that vision into reality.

Researchers You-Jun Fei and Vadivel Ganapathy have found the Indy gene is critical in providing cells with energy, producing a transporter that helps deliver key ingredients of the fuel that drives cells. Indy delivers metabolic substrates such as citrate and succinate to cells where they enter the powerhouse called the mitochondria. Inside the powerhouse, oxygen also is critical to the biochemical reaction that occurs to produce ATP, the fuel for cells, says Dr. Fei, molecular biologist.

An unfortunate byproduct of this oxygen metabolism is reactive oxygen species, a sort of cellular trash that ages cells and may contribute to diseases from Parkinson's to Alzheimer's. "This is why people think we age; these byproducts of oxygen metabolism cause cells to degenerate," says Dr. Ganapathy, biochemist who becomes chair of the MCG Department of Biochemistry and Molecular Biology July 1.

That also is why decreased activity of the Indy transporter seems to make animal models at least live longer, healthier lives.

The MCG researchers have identified this longevity gene in humans, mice, rats and zebrafish as well as C. elegans.

Armed with a new $605,000, three-year grant from the National Institutes of Health's Institute on Aging, the researchers want to know the activity level that optimizes longevity and find compounds to control that level.

"The human lifespan is a phenotype determined by multiple genes," says Dr. Fei, principal investigator on the grant. "Our Indy gene is only one of the life-determinant genes. But I can say that when the function of this single gene is knocked down, the animal can extend its lifespan."

University of Connecticut r
'"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
30-Jun-2004


Page: 1 2 3 4

Related biology news :

1. Clusters of alterations on PIK3CA gene found in brain cancers
2. Tamoxifen stimulates breast cancer growth following alteration of estrogen receptor
3. Fox Chase Cancer Center researchers identify significant smoking-induced genetic alteration
4. Researchers identify molecular alterations in patients with irritable bowel syndrome
5. Bacterial alterations source of persistent COPD lung infections
6. Gene alteration spurs growth of colon cancer
7. Unique genetic alteration in presenilin 1 gene predisposes some Caribbean Hispanics to early-onset Alzheimers disease
8. Gene alterations for cystic fibrosis may also account for chronic sinus problems in some
9. Gene alterations may predict response to new cancer therapy
10. Hunt for a new plant hormone points to carotenoids
11. Research points to potential obesity treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2020)... ... June 24, 2020 , ... eClinical ... clinical data services that accelerate drug development, is collaborating with Karyopharm Therapeutics (Nasdaq: ... in hospitalized patients with severe COVID-19. This is the first study of an ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... healthcare, and Renovagen Ltd, a UK supplier and manufacturer of innovative portable renewable ... testing operations in the fight against the COVID-19 pandemic in Zambia. , One ...
(Date:6/23/2020)... Texas (PRWEB) , ... June 23, 2020 , ... ... analytical instrumentation, is pleased to announce the next event in a series of ... scattering. , The TOPIQ series of webinars was developed in response to social ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is now offering ... 50 million stem cells total, patients may choose which extremities they would like treated. ... joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is obtained from ...
(Date:7/31/2020)... ... July 29, 2020 , ... eSource has long been touted as ... cover the history of eSource, the reasons it did not take off as quickly ... site source, the industry is moving towards capturing data electronically for clinical trials and ...
(Date:7/18/2020)... ... July 16, 2020 , ... “We are thrilled to deliver this new ... only technology of its kind on the market and we were pleased that the ... capacity of traditional cultured ingredients, creating a natural way to extend the shelf life ...
(Date:7/10/2020)... ... July 09, 2020 , ... In most research ... to suppress pigment formation in zebrafish embryos, maintaining optical transparency to facilitate microscopic ... MA has been using the zebrafish model to investigate the causes of leukaemia ...
Breaking Biology Technology:
Cached News: