HOME >> BIOLOGY >> NEWS
Gene alteration spurs growth of colon cancer

This type of methylation produces an abnormal off switch that in this case inappropriately shuts down production of a tumor suppressor protein, said Markowitz. The methylation process has also been implicated in turning off other tumor suppressor genes and is recognized as a contributor to the development of cancer.

When the scientists introduced a functional copy of the HLTF gene into the colon cancer cell lines that lacked the gene, the cells stopped growing. This finding suggests that the HLTF gene is itself a tumor suppressor gene that can stop tumors from growing.

Markowitz said that the studies also hint that drugs that reverse methylation may be a new type of cancer treatment. These drugs are now in the early stages of development. In the short term, however, Markowitz believes the finding may help doctors diagnose colon cancer and perhaps differentiate aggressive, invasive tumors from less aggressive forms of colon cancer.

When Markowitz and his colleagues looked in lung and breast cancer cells, they found the HLTF gene was normal. Based on this result, they concluded that the HLTF gene may be involved specifically in colon cancer progression. Furthermore, the scientists had previously detected abnormal methylated DNA in the blood of some colon cancer patients, suggesting that if the findings hold for the commonly methylated HLTF gene, it could be a target for a new diagnostic test for colon cancer. Markowitz cautioned that the result needs to be duplicated and other cancer cells need to be tested.

Markowitz is optimistic, and he cites recent work by HHMI investigator Bert Vogelstein at The Johns Hopkins University School of Medicine that demonstrates a new targeted, non-invasive test for finding about half of colon cancers using the APC tumor sup
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
2-Apr-2002


Page: 1 2 3

Related biology news :

1. Clusters of alterations on PIK3CA gene found in brain cancers
2. Gene alteration points to longevity, thinness
3. Tamoxifen stimulates breast cancer growth following alteration of estrogen receptor
4. Fox Chase Cancer Center researchers identify significant smoking-induced genetic alteration
5. Researchers identify molecular alterations in patients with irritable bowel syndrome
6. Bacterial alterations source of persistent COPD lung infections
7. Unique genetic alteration in presenilin 1 gene predisposes some Caribbean Hispanics to early-onset Alzheimers disease
8. Gene alterations for cystic fibrosis may also account for chronic sinus problems in some
9. Gene alterations may predict response to new cancer therapy
10. Chemical industry research commitment spurs CIIT growth
11. Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2017)... ITHACA, N.Y. , June 23, 2017 ... a leader in dairy research, today announced a new ... help reduce the chances that the global milk supply ... this dairy project, Cornell University has become the newest ... Food Supply Chain, a food safety initiative that includes ...
(Date:5/23/2017)...  Hunova, the first robotic gym for the rehabilitation and functional motor ... Genoa, Italy . The first 30 robots will be ... USA . The technology was developed and patented at the ... spin-off Movendo Technology thanks to a 10 million euro investment from entrepreneur ... ...
(Date:5/16/2017)...   Bridge Patient Portal , an enterprise ... EMR Systems , an electronic medical record solutions ... established a partnership to build an interface between ... Centricity™ products, including Centricity Practice Solution (CPS), Centricity ... new integrations will allow healthcare delivery networks using ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... 12, 2017 , ... DuPont Pioneer and recently formed CasZyme, ... into a multiyear collaboration to identify and characterize novel CRISPR-Cas nucleases. The goal ... editing across all applications. , Under the terms of the agreement, Pioneer will ...
(Date:10/11/2017)... ... 11, 2017 , ... At its national board meeting in ... Sheikh, the co-founder, CEO and chief research scientist of Minnesota-based Advanced Space Technology ... in ARCS Alumni Hall of Fame . ASTER Labs is a technology ...
(Date:10/11/2017)... -- VMS BioMarketing, a leading provider of patient support solutions, has ... (CNE) network, which will launch this week. The VMS CNEs ... professionals to enhance the patient care experience by delivering peer-to-peer ... care professionals to help women who have been diagnosed and ... ...
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... San Diego-based ... of its corporate rebranding initiative announced today. The bold new look is part ... as the company moves into a significant growth period. , It will also expand ...
Breaking Biology Technology:
Cached News: