HOME >> BIOLOGY >> NEWS
Gene associatied with lupus identified

Researchers at the University of Minnesota have identified, for the first time, a gene variation associated with systemic lupus erythematosus (SLE), a complex, inflammatory autoimmune disease that affects multiple organs. The gene variation, known as PTPN22, is found in approximately 16 percent (or one in six) of healthy Caucasians in the United States. However, nearly one in four (or 23 percent) lupus patients carry this variant, which has also now been associated with risk for type 1 diabetes and rheumatoid arthritis. The study is published in the September edition of the American Journal of Human Genetics.

"This appears to be a very important gene for lupus," said Timothy W. Behrens, M.D., professor of medicine, Medical School, and principal investigator, "and this is the first time we have identified a variant that predisposes to many different autoimmune diseases. We hope that this discovery will lead to the identification of other genes associated with lupus and other immune disorders." Behrens believes that dozens of genes may be responsible for lupus and that discovering the combination of these genes will be important to developing better diagnosis and treatment of the disease.

In SLE, a person's immune system begins attacking its own tissues. Organs commonly targeted in SLE include the skin, kidneys, joints, lungs, and the central nervous system. The severity of disease and the response to therapy vary widely between patients, said Behrens, and this leads to significant challenges in the diagnosis and management of lupus. "If we know which genes predispose a person to lupus, we may be able to diagnose and treat the disease earlier," he said. "In addition to discovering which combination of genes lead to lupus and other immune diseases, we also hope this information will help us identify new drugs and therapies."


'"/>

Contact: Brenda Hudson
bhudson@umn.edu
612-624-5680
University of Chicago Press Journals
18-Aug-2004


Page: 1

Related biology news :

1. Lack of immune system protein prevents lupus-like condition in mice
2. Lupus Research Institute awards $3 million in novel research grants to further new science in lupus
3. High heart risk for lupus patients linked to death of cells lining blood vessels
4. Researchers determine a contributing genetic factor of photosensitivity in lupus patients
5. Researchers show autoantibodies occur before lupus in New England Journal of Medicine
6. Gene defect produces lupus-like disorder
7. Binding studies suggest drug development strategy for lupus
8. Treatment of lupus in mice may point the way to human treatment
9. Yale researchers shed light on B cells involvement in autoimmune diseases like lupus
10. FDA clears for market new diagnostic test for lupus
11. Biologists track down central cause of lupus

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene associatied with lupus identified

(Date:3/17/2015)... 2015  MecklerMedia Corporation (OTCQX: MECK) announced its ... robots ever held in New York ... 11-13, 2015 at the Javits Convention Center. ... include: Acorn Product Development; Axis NJ; c-Link Systems; ... Littler; NewBotic Corporation; Neya Systems LLC; Reliabotics; RoboKind; ...
(Date:3/12/2015)... 12, 2015 Beta Systems ... and access management (IAM) solution for a fixed ... Beta System,s new IAM package, customers benefit from ... from multiple IAM implementations across different industries. The ... well as any necessary services and consulting. It ...
(Date:3/10/2015)... -- Continuing its 167-year history of offering the Best, the ... Eye Scanning Password Authenticator , a device that confirms ... or sensitive data. Employing the same biometric ... device has a small camera that scans and saves ... them into an encrypted ID that cannot be forged ...
Breaking Biology News(10 mins):MecklerMedia's RoboUniverse New York Announces Sponsors and Exhibitors, May 11-13, 2015 2Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2Hammacher Schlemmer Introduces The Eye Scanning Password Authenticator 2
(Date:3/29/2015)... 29, 2015 As a symbol of ... by our pharmaceutical manufacturing clients, Whitehouse Laboratories is excited ... the Berkenstock Race Team for the 2015 race season. ... speed, but a strong sense of precision and attention ... to success in the quality control testing laboratory. Sponsorship ...
(Date:3/27/2015)... March 27, 2015 The consumption of ... of the recession and high prices in 2008. However, ... recovered and keeps on gaining momentum now. , To ... at more than 100,000 thousand tonnes. No considerable growth ... the global capacity rocketed during 2012-2013, registering 11% growth ...
(Date:3/27/2015)... March 27, 2015  Neogen Corporation (NASDAQ: NEOG ... a prearranged trading plan in accordance with Securities and ... and CEO of Neogen Corporation, is a minority owner ... common stock. Herbert does not have control ... The filing is only for a portion of the ...
(Date:3/27/2015)...  Peter Walter was chosen as winner of the ... on how proteins are transported between cellular compartments and ... cells use to handle stress tied to the aggregation ... biochemistry at the University of California, San Francisco. His ... human diseases related to defective protein folding and transport. ...
Breaking Biology Technology:Whitehouse Laboratories Reaffirms Commitment to Speedy Results – Renews Sponsorship of Berkenstock Racing Team 2World NPK Fertilizers Market Keeps On Gaining Momentum, According to BAC Reports Study Available at MarketPublishers.com 2World NPK Fertilizers Market Keeps On Gaining Momentum, According to BAC Reports Study Available at MarketPublishers.com 3Neogen CEO adopts 10b5-1 Trading Plan 2German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 2German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 3
Cached News: