HOME >> BIOLOGY >> NEWS
Gene associatied with lupus identified

Researchers at the University of Minnesota have identified, for the first time, a gene variation associated with systemic lupus erythematosus (SLE), a complex, inflammatory autoimmune disease that affects multiple organs. The gene variation, known as PTPN22, is found in approximately 16 percent (or one in six) of healthy Caucasians in the United States. However, nearly one in four (or 23 percent) lupus patients carry this variant, which has also now been associated with risk for type 1 diabetes and rheumatoid arthritis. The study is published in the September edition of the American Journal of Human Genetics.

"This appears to be a very important gene for lupus," said Timothy W. Behrens, M.D., professor of medicine, Medical School, and principal investigator, "and this is the first time we have identified a variant that predisposes to many different autoimmune diseases. We hope that this discovery will lead to the identification of other genes associated with lupus and other immune disorders." Behrens believes that dozens of genes may be responsible for lupus and that discovering the combination of these genes will be important to developing better diagnosis and treatment of the disease.

In SLE, a person's immune system begins attacking its own tissues. Organs commonly targeted in SLE include the skin, kidneys, joints, lungs, and the central nervous system. The severity of disease and the response to therapy vary widely between patients, said Behrens, and this leads to significant challenges in the diagnosis and management of lupus. "If we know which genes predispose a person to lupus, we may be able to diagnose and treat the disease earlier," he said. "In addition to discovering which combination of genes lead to lupus and other immune diseases, we also hope this information will help us identify new drugs and therapies."


'"/>

Contact: Brenda Hudson
bhudson@umn.edu
612-624-5680
University of Chicago Press Journals
18-Aug-2004


Page: 1

Related biology news :

1. Lack of immune system protein prevents lupus-like condition in mice
2. Lupus Research Institute awards $3 million in novel research grants to further new science in lupus
3. High heart risk for lupus patients linked to death of cells lining blood vessels
4. Researchers determine a contributing genetic factor of photosensitivity in lupus patients
5. Researchers show autoantibodies occur before lupus in New England Journal of Medicine
6. Gene defect produces lupus-like disorder
7. Binding studies suggest drug development strategy for lupus
8. Treatment of lupus in mice may point the way to human treatment
9. Yale researchers shed light on B cells involvement in autoimmune diseases like lupus
10. FDA clears for market new diagnostic test for lupus
11. Biologists track down central cause of lupus

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene associatied with lupus identified

(Date:5/28/2015)... , May 28, 2015 Industry analyst ... a new report titled "Markets for Self-Healing Materials: ... inorganic capsule and vascular systems, biomaterials, relevant shape ... to around $2.7 billion by 2020. ... extensive coverage of smart materials. Other recent n-tech reports ...
(Date:5/27/2015)... 27, 2015   Codonics (codonics.com), ... and image documentation solutions and Omnicell ... automation solutions, is pleased to announce their ... Safe Label System® (SLS), an award-winning FDA ... the Omnicell Anesthesia Workstation, helps prevent medication ...
(Date:5/26/2015)... Research and Markets ( ... "Saudi Arabia Biometric Systems Market Forecast and ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,The biometric systems market in ... to grow at over 22% CAGR through 2020 ... the surging demand for better biometric technologies in ...
Breaking Biology News(10 mins):The Market for Self-Healing Materials to Reach $2.7 Billion by 2020 Says New n-tech Research Study 2The Market for Self-Healing Materials to Reach $2.7 Billion by 2020 Says New n-tech Research Study 3Codonics and Omnicell Expand Partnership 2Codonics and Omnicell Expand Partnership 3Codonics and Omnicell Expand Partnership 4Saudi Arabia Biometric Systems Market Forecast and Opportunities, 2020 with Morpho Safran, ZK Technlogy, and Suprema Dominating 2
(Date:5/28/2015)... 28, 2015  Quest Diagnostics Incorporated (NYSE: DGX ... announced that it is scheduled to speak at the ... Steve Rusckowski , the company,s President and CEO, will ...  The presentation is scheduled for Tuesday, June 2, 2015 ... will be webcast live during the conference and will ...
(Date:5/28/2015)... 28, 2015 ... announced the addition of Jain PharmaBiotech,s ... Markets and Companies"  to their offering.  ... describes and evaluates animal biotechnology and ... pharmaceuticals as well as improvement in ...
(Date:5/28/2015)... , May 27, 2015 Research ... addition of Jain PharmaBiotech,s new report ... their offering. An increasing use ... industries is anticipated. Nanotechnology will be applied ... from formulations for optimal delivery to diagnostic ...
(Date:5/28/2015)... 2015 Research and Markets( http://www.researchandmarkets.com/research/l9dqwt/animal_genetics ) has ... by Products, by Testing services - Global Forecast to ... global animal genetics market is estimated to be worth ... CAGR of 8-9% during the forecast period of 2014 ... by increasing animal protein consumption, increasing adoption of advanced ...
Breaking Biology Technology:Quest Diagnostics to Speak at the Jefferies 2015 Global Healthcare Conference 2Global Animal Biotechnology Report 2015 - Technologies, Markets and Companies Analysis to 2024 2Global Animal Biotechnology Report 2015 - Technologies, Markets and Companies Analysis to 2024 3Global Nanobiotechnology Market 2015-2024 - Applications, Markets and Companies 2Global Nanobiotechnology Market 2015-2024 - Applications, Markets and Companies 3Global Animal Genetics (Canine, Equine, Poultry, Porcine, Bovine, and Genetic Material) Market 2015 - Global Forecast to 2020 2
Cached News: