Gene associatied with lupus identified

Researchers at the University of Minnesota have identified, for the first time, a gene variation associated with systemic lupus erythematosus (SLE), a complex, inflammatory autoimmune disease that affects multiple organs. The gene variation, known as PTPN22, is found in approximately 16 percent (or one in six) of healthy Caucasians in the United States. However, nearly one in four (or 23 percent) lupus patients carry this variant, which has also now been associated with risk for type 1 diabetes and rheumatoid arthritis. The study is published in the September edition of the American Journal of Human Genetics.

"This appears to be a very important gene for lupus," said Timothy W. Behrens, M.D., professor of medicine, Medical School, and principal investigator, "and this is the first time we have identified a variant that predisposes to many different autoimmune diseases. We hope that this discovery will lead to the identification of other genes associated with lupus and other immune disorders." Behrens believes that dozens of genes may be responsible for lupus and that discovering the combination of these genes will be important to developing better diagnosis and treatment of the disease.

In SLE, a person's immune system begins attacking its own tissues. Organs commonly targeted in SLE include the skin, kidneys, joints, lungs, and the central nervous system. The severity of disease and the response to therapy vary widely between patients, said Behrens, and this leads to significant challenges in the diagnosis and management of lupus. "If we know which genes predispose a person to lupus, we may be able to diagnose and treat the disease earlier," he said. "In addition to discovering which combination of genes lead to lupus and other immune diseases, we also hope this information will help us identify new drugs and therapies."


Contact: Brenda Hudson
University of Chicago Press Journals

Page: 1

Related biology news :

1. Lack of immune system protein prevents lupus-like condition in mice
2. Lupus Research Institute awards $3 million in novel research grants to further new science in lupus
3. High heart risk for lupus patients linked to death of cells lining blood vessels
4. Researchers determine a contributing genetic factor of photosensitivity in lupus patients
5. Researchers show autoantibodies occur before lupus in New England Journal of Medicine
6. Gene defect produces lupus-like disorder
7. Binding studies suggest drug development strategy for lupus
8. Treatment of lupus in mice may point the way to human treatment
9. Yale researchers shed light on B cells involvement in autoimmune diseases like lupus
10. FDA clears for market new diagnostic test for lupus
11. Biologists track down central cause of lupus

Post Your Comments:

(Date:11/17/2015)... EASTON, Mass. , Nov. 17, 2015 ... a leader in the development and sale of broadly ... the worldwide life sciences industry, today announced it has ... of its $5 million Private Placement (the "Offering"), increasing ... to $4,025,000.  One or more additional closings are expected ...
(Date:11/12/2015)... BOSTON , Nov. 12, 2015  A golden ... for Duchenne muscular dystrophy (DMD) has provided a new ... Boston Children,s Hospital, the Broad Institute of MIT and ... Brazil . Cell, ... some dogs "escape" the disease,s effects. The Boston Children,s ...
(Date:11/12/2015)... , Nov. 11, 2015   Growing ... reliable analytical tools has been paving the way ... qualitative determination of discrete analytes in clinical, agricultural, ... are being predominantly used in medical applications, however, ... environmental sectors due to continuous emphasis on improving ...
Breaking Biology News(10 mins):
(Date:11/23/2015)... Nov. 24, 2015 Women with a certain type ... face a higher risk of lung cancer than men with ... week at the annual meeting of the Radiological Society of ... --> --> Lung nodules are small ... solid or subsolid based on their appearance on CT. Solid ...
(Date:11/23/2015)... 2015 China Cord Blood Corporation (NYSE: ... of cord blood collection, laboratory testing, hematopoietic stem cell ... preliminary unaudited financial results for the second quarter and ... 2015. --> --> ... for the second quarter of fiscal 2016 increased by ...
(Date:11/23/2015)... Church, VA (PRWEB) , ... November 23, 2015 , ... ... Ellen McCarthy , former Director, Plans and Programs, National Geospatial Intelligence Agency (NGA), has ... to us with an incredibly distinguished career in the intelligence community and the private ...
(Date:11/23/2015)... and PISCATAWAY, New Jersey ... Cambridge Crystallographic Data Centre (CCDC) announces the ... Structural Database (CSD) and the CSD-System, now complemented ... worldwide: CSD-Discovery to support the discovery of new ... and CSD-Enterprise, the complete set of the CCDC,s ...
Breaking Biology Technology:
Cached News: