HOME >> BIOLOGY >> NEWS
Gene at root of urban air pollution's lung effects

ORLANDO, Fla. Duke University Medical Center pulmonologists have linked a gene to the lung irritation commonly suffered following chronic exposure to ozone, a major component of urban air pollution. Should the new finding in mice be corroborated in human studies, drugs that block the function of the gene might serve as useful treatments for patients with asthma, the researchers said.

The new study adds to earlier work highlighting the importance of genetic factors in determining the lung's response to environmental toxins by pinpointing a key player in the process, said Duke pulmonologist John Hollingsworth II, M.D., lead author of the study.

"The lung is constantly exposed to a broad spectrum of environmental toxins, which can impact the severity of asthma," said Hollingsworth. "While the body's response to environmental exposures can facilitate the clearance of pathogens, it can also lead to injury and compromised lung function. By understanding the molecular mechanisms that initiate inflammation and injury, we may advance on new treatments to prevent the damage."

Hollingsworth presented the research at the 100th International Conference of the American Thoracic Society on May 25, 2004. The study will also appear in a forthcoming issue of the American Journal of Respiratory and Critical Care Medicine. The work was supported by the Department of Veterans' Affairs, the National Institute of Environmental Health Sciences, the National Heart Lung and Blood Institute and GlaxoSmithKline.

Ozone is an unstable molecule comprising three oxygen atoms. Natural ozone in the upper atmosphere plays an important role in filtering out ultraviolet rays from the sun. In the lower atmosphere, however, man-made ozone pollution results from a chemical reaction with nitrous oxide compounds released in automobile exhaust and industrial emissions, particularly under warm, sunny conditions. Such ozone is toxic in small concentrations and can exacerbate as
'"/>

Contact: Kendall Morgan
kendall.morgan@duke.edu
919-684-4148
Duke University Medical Center
25-May-2004


Page: 1 2 3

Related biology news :

1. New Arizona State center brings science to policy on issues of water resources and urban growth
2. Diabetics face fewer healthy food choices in some urban areas
3. Better living through urban ecology
4. Warmer weather, human disturbances interact to change forests
5. Edible urban plants found to contain lead
6. Researchers find luxury effect helps determine plant diversity in urban areas
7. Highway deaths highest for males Male urban squirrels, that is
8. USDA Forest Service publishes wildland-urban interface assessment
9. Agriculture presents common ground for rural, urban people
10. People and fire at Floridas wildland-urban interface
11. Planning could preserve urban forests for future enjoyment

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene root urban air pollution lung effects

(Date:8/4/2015)... -- AMRI (NASDAQ: AMRI ) today reported financial and operating results ... , Second quarter contract revenue of $ 85.2 ... Adjusted contract margins of 26 % , ... decrease in EPS from royalties in the current quarter ... "We are very pleased to present another strong financial quarter, with ...
(Date:7/31/2015)... -- Den 10. internationale konference om Genomik (ICG-10, ... 25. oktober i Shenzhen , Kina. ... år. Siden starten i 2006 er ICB blevet en ... er en af de mest dynamiske, entusiastiske og sjove ... gennembrud og fremskridt inden for ,omik,-forskning, som yderligere vil ...
(Date:7/31/2015)... de julho de 2015 A 10 a. ... será realizada pela BGI de 22-25 de outubro de 2015, ... A conferência está celebrando seu 10 o. aniversário ... se tornou uma das reuniões mais influentes do mundo ... mais dinâmicos, entusiastas e prazerosos. A ...
Breaking Biology News(10 mins):AMRI Announces Second Quarter 2015 Results 2AMRI Announces Second Quarter 2015 Results 3AMRI Announces Second Quarter 2015 Results 4AMRI Announces Second Quarter 2015 Results 5AMRI Announces Second Quarter 2015 Results 6AMRI Announces Second Quarter 2015 Results 7AMRI Announces Second Quarter 2015 Results 8AMRI Announces Second Quarter 2015 Results 9AMRI Announces Second Quarter 2015 Results 10AMRI Announces Second Quarter 2015 Results 11AMRI Announces Second Quarter 2015 Results 12AMRI Announces Second Quarter 2015 Results 13AMRI Announces Second Quarter 2015 Results 14AMRI Announces Second Quarter 2015 Results 15AMRI Announces Second Quarter 2015 Results 16AMRI Announces Second Quarter 2015 Results 17AMRI Announces Second Quarter 2015 Results 18AMRI Announces Second Quarter 2015 Results 19AMRI Announces Second Quarter 2015 Results 20AMRI Announces Second Quarter 2015 Results 21AMRI Announces Second Quarter 2015 Results 22AMRI Announces Second Quarter 2015 Results 23AMRI Announces Second Quarter 2015 Results 24Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3
(Date:8/3/2015)... Delaware , August 3, 2015 ... in the commercialization of its Bio-electrical Signal Therapy device ... noninvasive treatment of hard to heal chronic wounds, today ... agreement with Chemipal, an Israeli distributor specializing in medical ... device. Chemipal is a 70 years old, ...
(Date:7/31/2015)... July 31, 2015 In today,s fast ... help them drive positive health outcomes, improve profitability ... of patient care in their communities. At ThoughtSpot ... and conference, AmerisourceBergen announced a new set of ... Administration Organization and help independent pharmacies endure the ...
(Date:7/30/2015)... 2015 AACC welcomed thousands of medical ... Annual Meeting & Clinical Lab Expo in ... meeting showcased revolutionary advancements in clinical testing technology ... providers to diagnose patients quickly and accurately and ... As of Wednesday, July 29, more ...
(Date:7/30/2015)... San Diego , CA (PRWEB) , ... July ... ... Biopharma, announced the successful completion of a field clinical study of its canine ... being developed together with Aratana Therapeutics (Kansas City, KS) and will be marketed ...
Breaking Biology Technology:E-QURE Corp Signs Second Distribution Agreement in Israel 2E-QURE Corp Signs Second Distribution Agreement in Israel 3AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 2AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 3Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 2Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 3Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 4VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 3
Cached News: