HOME >> BIOLOGY >> NEWS
Gene at root of urban air pollution's lung effects

ORLANDO, Fla. Duke University Medical Center pulmonologists have linked a gene to the lung irritation commonly suffered following chronic exposure to ozone, a major component of urban air pollution. Should the new finding in mice be corroborated in human studies, drugs that block the function of the gene might serve as useful treatments for patients with asthma, the researchers said.

The new study adds to earlier work highlighting the importance of genetic factors in determining the lung's response to environmental toxins by pinpointing a key player in the process, said Duke pulmonologist John Hollingsworth II, M.D., lead author of the study.

"The lung is constantly exposed to a broad spectrum of environmental toxins, which can impact the severity of asthma," said Hollingsworth. "While the body's response to environmental exposures can facilitate the clearance of pathogens, it can also lead to injury and compromised lung function. By understanding the molecular mechanisms that initiate inflammation and injury, we may advance on new treatments to prevent the damage."

Hollingsworth presented the research at the 100th International Conference of the American Thoracic Society on May 25, 2004. The study will also appear in a forthcoming issue of the American Journal of Respiratory and Critical Care Medicine. The work was supported by the Department of Veterans' Affairs, the National Institute of Environmental Health Sciences, the National Heart Lung and Blood Institute and GlaxoSmithKline.

Ozone is an unstable molecule comprising three oxygen atoms. Natural ozone in the upper atmosphere plays an important role in filtering out ultraviolet rays from the sun. In the lower atmosphere, however, man-made ozone pollution results from a chemical reaction with nitrous oxide compounds released in automobile exhaust and industrial emissions, particularly under warm, sunny conditions. Such ozone is toxic in small concentrations and can exacerbate as
'"/>

Contact: Kendall Morgan
kendall.morgan@duke.edu
919-684-4148
Duke University Medical Center
25-May-2004


Page: 1 2 3

Related biology news :

1. New Arizona State center brings science to policy on issues of water resources and urban growth
2. Diabetics face fewer healthy food choices in some urban areas
3. Better living through urban ecology
4. Warmer weather, human disturbances interact to change forests
5. Edible urban plants found to contain lead
6. Researchers find luxury effect helps determine plant diversity in urban areas
7. Highway deaths highest for males Male urban squirrels, that is
8. USDA Forest Service publishes wildland-urban interface assessment
9. Agriculture presents common ground for rural, urban people
10. People and fire at Floridas wildland-urban interface
11. Planning could preserve urban forests for future enjoyment

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene root urban air pollution lung effects

(Date:12/17/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ) ... Galaxy S5 - Home Button Synaptics Fingerprint Sensor ... http://photos.prnewswire.com/prnh/20130307/600769 ... the iPhone 5S, Samsung introduces for the first ... The Galaxy S5 home button presents an ...
(Date:12/17/2014)... DENVER , Dec. 16, 2014  Automation ... is this more evident than at international borders. ... secure document scanners have allowed veteran travelers to ... Automated Passport Control (APC) Kiosks at an increasing ... the globe. According to ...
(Date:12/11/2014)... PAUL, Minn. , Dec. 10, 2014 /PRNewswire/ ... wireless physiologic monitoring, has released a new series ... needs of preclinical toxicology researchers. M series, part ... help toxicologists collect the best possible physiologic data ... Adding functional endpoints to toxicology studies ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2New telemetry implants expected to change how large animal toxicology studies are conducted 2
(Date:12/19/2014)...   ISN has released its third annual ... publication series. With data aggregated from over eight ... within its online contractor management platform, ISNetworld, this three-part ... (KPI) statistics. The Contractor ... is available in two industry specific volumes: Oil ...
(Date:12/17/2014)... December 17, 2014 Based on ... overall surgical imaging market is dominated by four ... surgical imaging market. These players include GE Healthcare ... Imaging (Germany). , Full Report Copy at ... GE Healthcare can be attributed to its strong ...
(Date:12/17/2014)... 17, 2014 Ipsen Biopharmaceuticals, Inc., ... ADR: IPSEY), today announced that Somatuline® ... Somatuline®) was approved by the U.S. Food and ... neuroendocrine tumors (GEP-NETs) in adult patients with unresectable, ... disease to improve progression-free survival (PFS). , “The ...
(Date:12/17/2014)... Xeno Diagnostics has again received an ... COLA inspection. Xeno has met all criteria for ... organization. Accreditation is earned only by laboratories that ... demonstrate continued accuracy in the performance of proficiency ... , While the Laboratory Excellence award ...
Breaking Biology Technology:ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 4Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 2Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 3Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 4Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 5Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 6Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 7Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 8Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2
Cached News: