HOME >> BIOLOGY >> NEWS
Gene-based screen sorts cancer cases, say Stanford researchers

STANFORD, Calif. - Six genes may hold the answer to whether a person's lymphoma is likely to respond to treatment. This finding by researchers at Stanford University School of Medicine could result in the first gene-based screen to identify people who need the most aggressive therapy.

When a person is diagnosed with diffuse large-B-cell lymphoma, doctors use a group of indicators called the International Prognostic Index, or IPI, which includes a person's age, tumor stage and blood markers to decide how to treat the cancer. Those with the highest IPI scores get the most aggressive therapy. However, two people with the same score may still react differently to treatment. One thought has been that a genetic screen may fine-tune the distinction between the most aggressive and least aggressive cancers.

"It makes a big difference in your treatment decisions if you think you have a high chance of success or if you don't," said Ronald Levy, MD, the Robert K. and Helen K. Summy Professor, who led the study. He said if doctors know a patient isn't likely to respond well to standard therapy, the patient may be a candidate for novel therapies undergoing clinical trials.

"New therapies are usually tested in people who have failed the standard therapy," Levy said. "If you know in advance who won't respond well, you can treat them more aggressively or include these patients in trials of the many promising, new targeted therapies."

Over the past five years groups of researchers have used microarrays, which take a snapshot of which genes are active in different tissues, to find large groups of genes that predict a person's survival. These studies have resulted in huge lists of mostly non-overlapping genes. Not only are there too many genes to be screened by most medical labs, the research groups haven't agreed on which genes should be part of those screens.

Levy and his colleagues narrowed the list of potentially informative genes down to the
'"/>

Contact: Amy Adams
650-723-3900
Stanford University Medical Center
28-Apr-2004


Page: 1 2 3

Related biology news :

1. March of Dimes statement on newborn screening report
2. Virus known for its photo ops makes its movie screen debut
3. Only 21 states offer newborn screening tests recommended by March of Dimes
4. New screening method turns up potential compound for treating anthrax
5. Genome-wide screen reveals new tricks of old genes
6. Genetic screening study at Stanford IDs most aggressive adult leukemia strains
7. New, non-radioactive screen for antimalarial compounds
8. Genetic screening recommended to detect new neurodegenerative disorder in men over age 50
9. HPV testing could be future strategy for primary screening for cervical cancer
10. Newborn screening for certain genetic disorders has benefits and some drawbacks
11. UCSD scientists develop novel way to screen molecules

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/29/2019)... ... August 28, 2019 , ... ... and Clinical Research Organization), have recently passed their five-year milestone of collaboration ... and psychoneuroendocrine stress expertise, with a primary focus towards performing feasibility studies, ...
(Date:8/27/2019)... , ... August 27, 2019 , ... ... service, is pleased to announce that it has partnered with Bertec, a leading ... designs and manufactures Balance Advantage systems, a full line of clinical systems for ...
(Date:8/27/2019)... ... 27, 2019 , ... Advancements with Ted Danson will focus ... to broadcast 4Q/2019. Check local listings for more information. , This segment ... The show will highlight how Debiopharm is working to champion the synergy between ...
Breaking Biology News(10 mins):
(Date:9/11/2019)... ... 2019 , ... Catalent, the leading global provider of advanced ... health products, today announced that Alex Haig, Senior Director, Engineering will present at ... Hall, Germany, on Sept. 18-19, 2019. , On Wednesday, Sept. 18 at 10:45 ...
(Date:9/8/2019)... (PRWEB) , ... September 05, 2019 , ... ... that Blaine Fitzgerald, former Vice President of Finance for Shopify, has been named ... Jones and healthcare venture capitalist Joel Finlayson as strategic advisors. Additionally, Spartan has ...
(Date:8/29/2019)... , ... August 29, 2019 , ... ... disease affecting grapevines, a feat they hope will ultimately help protect the multibillion-dollar ... including several Rochester Institute of Technology faculty and alumni sequenced the microbiome found ...
(Date:8/27/2019)... , ... August 27, 2019 , ... Dr. Kim Carlson ... recently opened North Peninsula Veterinary Surgical Group , a new surgical practice in ... are plans to expand and add more veterinary specialists as the practice grows. , ...
Breaking Biology Technology:
Cached News: