HOME >> BIOLOGY >> NEWS
Gene changes linked to increased eye pressure may have implications for glaucoma therapy

CHAPEL HILL University of North Carolina at Chapel Hill scientists have discovered that increased pressure within the eye alters a set of genes normally involved in preventing hardening of tissue.

Increased eye pressure often occurs in glaucoma, a blinding eye disease that affects about 70 million people worldwide, and the new findings may have implications for treating this disease. The study currently appears in the online October issue of the Journal of Cellular Physiology.

"Pressure is required in the eye to keep its shape, and this pressure is maintained in the front part of the eye by a fluid, the aqueous humor," said Dr. Teresa Borrs, the paper's senior author and professor of ophthalmology in UNC's School of Medicine. From 1997 to 2002, Borrs held a Research to Prevent Blindness Jules and Doris Stein Professorship Award.

The aqueous humor is created by the ciliary body, a tissue beneath the eye's iris. The fluid flows around the iris and out through the trabecular meshwork, or TM, a spongy tissue that provides resistance and maintains the pressure, Borrs said.

Often in glaucoma, the TM stops working and fluid builds up within the eye, causing pressure inside the eye to rise. When this happens, the optic nerve in the back of the eye can become squeezed. As this is the area that carries the visual signals from eye to brain, vision loss can occur, Borrs said.

In earlier studies, Borrs and her research group had shown that a greater outflow of fluid occurred when researchers artificially increased the pressure in human donor eyes.

"It was like the TM had a homeostatic counteracting mechanism that could sense an increase in pressure and open up a little bit, to help move the fluid out of the eye," said Borrs.

However, it was unclear how the TM achieved this pressure regulation. This study was aimed at measuring what genes were turned on or off in the TM after the pressu
'"/>

Contact: Leslie H. Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
12-Aug-2004


Page: 1 2

Related biology news :

1. Adaptive changes in the genome may provide insight into the genetics of complex disease
2. Study finds plant enzyme function changes with location in cell
3. Protein controls acid in cells by direct detection of volume changes, study finds
4. Gene mutation causes progressive changes to cell structure in children with Progeria
5. Researchers develop blood test that can detect genetic changes in progressive breast cancer
6. Unexpected changes in Earths climate observed on the dark side of the moon
7. Small gene changes in some leukemia patients may explain varying responses to chemotherapy
8. Childrens eating patterns show striking changes in two decades
9. New method is first to mimic subtle genetic changes
10. Researchers identify the pattern of gene-expression changes for tuberculosis in a living host
11. Scientist works to interrupt early changes resulting in diabetic vision loss

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/6/2019)... MEXICO CITY (PRWEB) , ... June 05, 2019 ... ... temperature-controlled packaging, announces the opening of a new network station and service center ... America — and 12th in the world — with more than $1.75 billion ...
(Date:6/4/2019)... ... June 04, 2019 , ... Most preclinical EEG ... seizure risk signals, usually based on variations of amplitude, frequency or spike train ... diagnostic methodology due to the complexity and variability of the signal, and automation ...
(Date:5/31/2019)... ... May 30, 2019 , ... ... and Mayo Clinic, have documented significant differences in the prevalence of hereditary genetic ... populations compared to non-Hispanic White women. Results will be presented at the 2019 ...
Breaking Biology News(10 mins):
(Date:6/6/2019)... ... June 05, 2019 , ... WCCT Global, Inc ... device industries, announced today that they will be receiving 3 awards at the 2019 ... WCCT received 2 awards in the categories of overall Quality and Compatibility (Access to ...
(Date:5/31/2019)... , ... May 30, 2019 , ... ... is pleased to announce the strategic acquisition of Metabiologics, Inc., a globally recognized ... provides Object exclusive ownership and commercialization rights to a full spectrum of botulinum ...
(Date:5/15/2019)... ... ... Milton Hershey School® has named William Charles Ballough Harding ’78 the 2019 ... he is changing lives by creating solutions to global healthcare challenges through the development ... our founders – Milton and Catherine Hershey – who always hoped for Milton Hershey ...
(Date:5/8/2019)... ... May 07, 2019 , ... Standing at 16.2 hands, Atlas is on the large side ... drill team and barrel racing, among other activities. When loping around a corner in ... from being a busy horse to only being able to walk. Fortunately Atlas’ owner, ...
Breaking Biology Technology:
Cached News: