Gene clusters predict atherosclerosis severity, susc...( locations groups. The genes in the seve...)

Gene clusters predict atherosclerosis severity, susceptibility

locations groups. The genes in the severity cluster tended to be involved in the inflammation process, while those related to susceptibility tend to mediate cellular responses that occur prior to the inflammatory process.

"While the methods we used to identify these genes do not have immediate clinical applications, they do play an important role in identifying genes for further study," Seo said. "The identification of these genes advances our understanding of the biological pathways relevant to atherosclerosis.

"Many of these genes are likely to be implicated in the disease process and may become targets of future therapies," Seo continued. "By identifying variants within these genes, we may be able to identify combinations of such variants that when taken together with known clinical risk factors, may lead to new prognostic and diagnostic tools for cardiovascular disease."

The research team plans further studies in animal mouse models of atherosclerosis to further refine their techniques. Since it is not practical to test samples of aortas in living patients, the also researchers hope to develop a way to correlate their findings in the aorta with possible markers in circulating blood.

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Contact: Richard Merritt
Merri006@mc.duke.edu
919-684-4148
Duke University Medical Center
28-Sep-2004

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