HOME >> BIOLOGY >> NEWS
Gene controls age at onset of Alzheimer's and Parkinson's diseases

DURHAM, N.C. - By applying a new technique that combines independent lines of genomic evidence, Duke University Medical Center researchers and colleagues have identified a single gene that influences the age at which individuals first show symptoms of Alzheimer's and Parkinson's diseases.

Such genes that can impact patients' age at onset for the two very prevalent neurological disorders are of particular interest as alternative targets for treatment, said Margaret Pericak-Vance, Ph.D., director of the Duke Center for Human Genetics. Drugs that delay the onset of Alzheimer's or Parkinson's diseases beyond the normal human lifespan would effectively prevent them in patients at risk for the disorders, she added.

Alzheimer's disease is the most common cause of dementia among people over the age of 65, affecting up to 4 million Americans. Parkinson's disease -- characterized by tremors, stiffness of the limbs and trunk, slow movements and a lack of balance -- afflicts approximately 50,000 Americans each year. Both are complex disorders involving multiple genes.

"Although physicians generally consider Alzheimer and Parkinson diseases to be distinct disorders, the two exhibit a lot of overlap both clinically and pathophysiologically," said Jeffery Vance, M.D., director of Duke's Morris K. Udall Parkinson's Disease Research Center and associate director of the Duke Center for Human Genetics. "This study emphasizes the similarity between the two diseases by highlighting a single gene that influences their age of onset."

The team reports their findings in the Dec. 15, 2003, issue (available online Oct. 21) of Human Molecular Genetics and will present the work as a keynote paper at the annual meeting of the American Society of Human Genetics, which will be held Nov. 4-8, in Los Angeles. The major funding for the study was provided by the National Institute on Aging, the National Institute of Neurological Disorders and Stroke, the Alzheimer
'"/>

Contact: Kendall Morgan
kendall.morgan@duke.edu
919-684-4148
Duke University Medical Center
21-Oct-2003


Page: 1 2 3

Related biology news :

1. Protein controls acid in cells by direct detection of volume changes, study finds
2. Biologists discover nerve activity, not just genetics controls kinds of neurotransmitters produced
3. Newly discovered gene controls levels of bad cholesterol in mice
4. Researchers find a protein that controls cell growth
5. Structure solved by Scripps scientists shows one way that body controls gene expression
6. New findings implicate cell size controls in a variety of diseases
7. Transplantation of embryonic pancreatic tissue controls Type 1 diabetes in rats
8. DNA throttle controls molecular machine
9. Modifier gene controls severity of neurological disease in mice
10. Salt controls size of DNA structures, could improve gene therapy
11. Single gene controls leaf form

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/4/2016)... , Feb. 4, 2016 The field ... one of the most popular hubs of the ... and other huge studies of human microbiota, have ... few years, the microbiome space has literally exploded ... research. This report focuses on biomedical aspects ...
(Date:2/2/2016)... 2016  BioMEMS devices deployed in hospitals ... medical screening and diagnostic applications, such as ... that facilitate and assure continuous monitoring without ... being bolstered through new opportunities offered by ... coupled with wireless connectivity and low power ...
(Date:2/2/2016)... 2, 2016  Based on its recent analysis ... recognizes US-based Intelligent Retinal Imaging Systems (IRIS) with ... for New Product Innovation. IRIS, a prominent cloud-based ... America , is poised to set the ... retinopathy market. The IRIS technology presents superior price-performance ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... 2016 Should antibiotic bone cement products be ... prevent infection after standard total hip or knee replacement ... Institute have been fielding a lot lately. ... Line?" --> "Antibiotic Bone Cement: ... --> While there isn,t a simple answer, ...
(Date:2/8/2016)... , February 8, 2016 ... Oncology Private Limited, an innovation-driven oncology company developing ... and less toxic, today announced that chairman emeritus ... has invested in the company as part of ... round, joining existing investors Navam Capital and Aarin ...
(Date:2/8/2016)... ... February 08, 2016 , ... Thomas ... is the Executive Vice President for Corporate Services and the Chief Financial Officer ... Payable, Payroll, Billing Operations, Treasury, Managed Care Contracting, Supply Chain, and Investments. , ...
(Date:2/8/2016)... Calverton, Maryland (PRWEB) , ... February 08, 2016 , ... ... our BSI Web product. The upgrade represents a completely new technical foundation and ... Engage will offer a responsive design interface, significantly increased speed for search results, a ...
Breaking Biology Technology:
Cached News: