Gene controls neural stem cell growth

Researchers have discovered that a gene previously implicated in a variety of forms of cancer is also a key regulator of neural stem cell proliferation. Understanding how the gene, called PTEN, promotes the proliferation of neural stem cells could aid efforts to use stem cells in treating neurological disorders.

Howard Hughes Medical Institute investigator Hong Wu and colleagues at the UCLA School of Medicine reported on the regulatory role of Pten in the November 1, 2001, Science Express, the online counterpart of the journal Science.

According to Wu, PTEN is the second most frequently deleted tumor suppressor gene, giving rise to human cancers including brain, breast, prostate, and endometrial cancers.

There was also evidence, said Wu, that the PTEN protein produced by the gene played a normal role in neural development. It was known that humans who have inherited deletions or mutations of the PTEN gene often showed macrocephaly, or abnormally large brains, she said.

The gene is expressed in the central nervous systems of developing human and mouse embryos, but no one had ever done a detailed study to understand the precise role of PTEN in the nervous system.

Knocking out the gene in mice caused early death in embryos, before significant brain development. So, Wu and her colleagues used the Cre-loxP system to genetically manipulate the mice so that the gene would be knocked out later in gestation. The researchers discovered that knocking out Pten in the mouse embryos appeared to hyper-activate a signaling pathway that regulates cell proliferation and cell death in the brain.

Anatomical studies revealed a significant increase in brain size in the mutant animals. The researchers also noted an increase in the size of the brain cells themselves the first evidence that the PTEN protein regulates cell size in mammals, said Wu. The scientists next used antibodies to mark specific types of brain cells.


Contact: Jim Keeley
Howard Hughes Medical Institute

Page: 1 2 3

Related biology news :

1. Protein controls acid in cells by direct detection of volume changes, study finds
2. Biologists discover nerve activity, not just genetics controls kinds of neurotransmitters produced
3. Newly discovered gene controls levels of bad cholesterol in mice
4. Researchers find a protein that controls cell growth
5. Structure solved by Scripps scientists shows one way that body controls gene expression
6. New findings implicate cell size controls in a variety of diseases
7. Gene controls age at onset of Alzheimers and Parkinsons diseases
8. Transplantation of embryonic pancreatic tissue controls Type 1 diabetes in rats
9. DNA throttle controls molecular machine
10. Modifier gene controls severity of neurological disease in mice
11. Salt controls size of DNA structures, could improve gene therapy

Post Your Comments:

(Date:5/11/2020)... ... May 11, 2020 , ... ... platform for patients with implanted cardiac devices. The Octagos software allows healthcare professionals ... The software greatly simplifies the management of remote transmissions and at the same ...
(Date:5/6/2020)... ... May 06, 2020 , ... The LaunchPort™ ... the latest out-of-state company to partner with the device accelerator located in ... a point-of-care analyzer capable of accurately performing enzyme-linked immunosorbent assays (ELISAs), the ...
(Date:5/1/2020)... ... 2020 , ... Flagship Biosciences , providers of expert ... and regulatory services advisor. The companies now deliver regulatory strategy and support to ... a collaborative approach to empower more confident and informed regulatory decisions through every ...
Breaking Biology News(10 mins):
(Date:5/14/2020)... WILMINGTON, Del. (PRWEB) , ... May 12, 2020 ... ... selection of Interdisp JCS as the new distribution partner for all personal care ... the DuPont GENENCARE®OSMS portfolio and DuPont preservative portfolio for personal care. , ...
(Date:5/14/2020)... ... May 13, 2020 , ... ... or phenotypic readouts, providing little or no information on the drug’s mechanism of ... comprehensive characterization of compounds by measuring the activity of molecular pathways. This information ...
(Date:5/5/2020)... ... May 05, 2020 , ... ProductLife Group has marked ... Duburcq joins the group after 13 years at Altran, where he was Group VP ... in Immunology and being a Pharmacist, Xavier was involved in his early career in ...
(Date:4/26/2020)... ... April 23, 2020 , ... Indegene Omnipresence, Inc. announced ... applications and services for use on Microsoft Azure. The customer experience management (CXM) ... online for a built-for-purpose customer engagement capability to use in their commercial or ...
Breaking Biology Technology:
Cached News: