Gene could hold key to predicting, combating life-threatening abnormal heart growth

DALLAS Aug. 23, 2002 Researchers at UT Southwestern Medical Center at Dallas have identified a gene they believe could predict risk for developing enlarged hearts and lead to treatments to control life-threatening heart growth.

In a study published in today's edition of Cell, a team led by Dr. Eric Olson, chairman of molecular biology at UT Southwestern, reports that the gene HDAC9 limits abnormal heart-muscle growth.

Olson said doctors have long understood that the heart becomes enlarged a condition called cardiac hypertrophy when it responds to stresses, including irregular heartbeat and high blood pressure.

Enlarged hearts frequently become dilated their inner chambers stretched beyond normal size and work less efficiently. The excess muscle also can disrupt the electrical signals that control heart rhythm. Cardiac hypertrophy frequently is a cause of sudden death among young athletes, who suffer cardiac arrest due to enlarged hearts without ever knowing they had the condition.

"Stress accelerates hypertrophic growth, and HDAC9 functions to restrict cardiac growth," said Olson. "If HDAC9 isn't present, it's like you have no brakes and the heart grows uncontrolled."

The new research also shows that HDAC9 specifically restricts cardiac growth in response to stress, but it does not restrict normal cardiac growth during development or in response to exercise.

Previous research had demonstrated that when the heart works harder than normal, a calcium sensor called calcineurin is activated and drives heart-muscle growth. The researchers showed that HDAC9 counteracts the calcineurin activity to short-circuit muscle growth.

While the gene doesn't completely stop heart enlargement, UT Southwestern researchers showed that HDAC9's presence significantly slows growth. Olson said the next step is to look at human subjects to see if abnormalities in HDAC9 coincide with abnormal heart growth.

"This gene exhibi

Contact: Wayne Carter
UT Southwestern Medical Center

Page: 1 2

Related biology news :

1. Landmark agreement between Samoa and UC Berkeley could help search for AIDS cure
2. Circulation of disaster myths in Haiti could hinder appropriate disposal of bodies
3. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
4. Marijuana use could cause tubal pregnancies
5. Gene chips research in cotton could lead to superior variety
6. Groundbreaking research could ignite new solutions to heat transfer in nano-devices
7. Bullish chemical could repel yellow fever mosquitoes
8. Termites could hold the key to self-sufficient buildings
9. Wastewater could treat itself, power city
10. Sugar-coated sea urchin eggs could have sweet implications for human fertility
11. Identifying tick genes could halt disease, bioterrorism threat

Post Your Comments:

(Date:6/13/2020)... ... June 11, 2020 , ... Bode Technology ... of its forensic genealogy team. Bode’s Forensic Genealogy Service (FGS) continues ... and DNA analysis methods. The team has added experienced genealogists, each having over ...
(Date:6/11/2020)... ... June 09, 2020 , ... Superior Controls, Inc. ... automation and IT solutions for the life sciences industry, is pleased to announce the ... working out of the company’s Seabrook, New Hampshire office. In his new role, ...
(Date:6/5/2020)... ... , ... “Although we are disappointed to have to make this decision our ... public. We remain committed to creating a global platform to showcase the science, ... President of WMIS. , The abstract deadline for the virtual meeting ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... Va. (PRWEB) , ... July 08, 2020 , ... ... testing services and products, announces a significant expansion of laboratory operations through its ... collection for agencies implementing testing programs. , Bode-CARES provides a ...
(Date:7/10/2020)... ... 2020 , ... In most research using the zebrafish model, ... in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging. Over the past ... the zebrafish model to investigate the causes of leukaemia and its relationship with ...
(Date:7/7/2020)... ... July 06, 2020 , ... R3 International is now offering stem ... 200 million stem cells. Depending on the patient's condition, treatment may be offered IV, ... die having some form of Alzheimers dementia, and the incidence continues to increase as ...
(Date:7/1/2020)... ... June 29, 2020 , ... ... date growth of 40% in 2020, despite many obstacles created as a result ... to increase revenue for its partnered medical practices and medical manufacturers by expanding ...
Breaking Biology Technology:
Cached News: