HOME >> BIOLOGY >> NEWS
Gene defects tied to inability of cells to repair DNA damage

In new research carrying implications for human disease development, University of North Carolina scientists and others have linked gene defects to the inability of cells to repair damaged DNA.

The findings published April 13 in the journal Cell offer new insights into how cells repair the DNA damage that may occur during normal metabolism. Such naturally occurring oxidative damage promotes tissue changes thought to be associated with disease development, including cancer, heart disease and rheumatoid arthritis.

Study co-author Steven A. Leadon, Ph.D., head of molecular radiobiology at the UNC Lineberger Comprehensive Cancer Center said "oxidative damage is probably the most common type of damage humans are exposed to because we live and breath oxygen, and oxygen can be reactive and cause DNA damage." Within cells, oxidation leads to formation of free radicals, short-lived highly active particles that occur naturally during metabolism. These are also introduced into the body through smoking, inhaling environmental pollutants, or exposure to the sun's ultraviolet (UV) radiation. From numerous studies, free radicals are known to interact readily with nearby molecules to cause cellular damage, including damage to genetic material.

Damage repair to an active gene, one that continually produces proteins crucial to cellular function, normally occurs through a process known as transcription coupled repair. "We were trying to understand how defects in one of the proteins required for this process works," Leadon said. "And what we were looking at was whether or not the defect has something to do with the inability to repair oxidative damage that occurs in a gene."

In 1998, Leadon and his UNC colleagues were the first to link the defective breast cancer gene BRCA1 to the inability of cells to correct DNA oxidative damage. His work directly demonstrated that BRCA1 was required for transcription-coupled repair. Those studies involved altered cells derived fro
'"/>

Contact: Leslie H. Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
13-Apr-2000


Page: 1 2 3

Related biology news :

1. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
2. Gene defects found in age-related macular degeneration
3. Antioxidants during pregnancy may help prevent birth defects tied to alcohol
4. LARGE protein can overcome defects in some types of muscular dystrophy
5. Cardiofunk mutation: Probable source of congenital heart defects
6. Fat cells heal skull defects in mice, Stanford research shows
7. Missing gene a potential risk factor for birth defects
8. Cystic fibrosis gene linked to fatty acid defects
9. Researchers show absence of key oxygen-sensing molecule leads to developmental defects
10. Researchers identify second gene responsible for rare syndrome associated with skeletal defects
11. Stem cell defects are key to Hirschsprungs disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/15/2016)... 2016 Transparency Market Research ... Market by Application Market - Global Industry Analysis Size Share ... the report, the  global gesture recognition market  was ... is estimated to grow at a CAGR of ... Increasing application of gesture recognition technology ...
(Date:6/9/2016)... Paris Police Prefecture and ... ensure the safety of people and operations in several locations ... Teleste, an international technology group specialised in broadband ... its video security solution will be utilised by ... across the country. The system roll-out is scheduled for the ...
(Date:6/3/2016)... 3, 2016 Das ... Nepal hat ein 44 ... geprägter Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, ... Produktion und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte ... Januar teilgenommen, aber Decatur wurde als konformste ...
Breaking Biology News(10 mins):
(Date:12/4/2016)... ... December 03, 2016 , ... Microbial genomics leader uBiome is ... has been made to Dr. Renato Polimanti of Yale University School of Medicine, ... microbiome. Grant proposals have been vetted by the company’s scientific review committee. ...
(Date:12/2/2016)... ... December 02, 2016 , ... In ... cervical and lumbar disc production, company President, Jake Lubinski will be traveling to ... the AxioMed disc in Bern, Lucerne, and Zurich to discuss the benefits of ...
(Date:12/2/2016)... Dec. 2, 2016 Amgen (NASDAQ: AMGN ... announced the submission of a Marketing Authorization Application (MAA) to ... candidate to Avastin ® (bevacizumab). The companies believe this ... EMA. "The submission of ABP 215 to ... expand our oncology portfolio," said Sean E. Harper , ...
(Date:12/2/2016)... , ... December 01, 2016 , ... ACEA Biosciences, Inc. ... Phase I/II clinical trials for AC0010 at the World Conference on Lung Cancer 2016, ... an update on the phase I/II clinical trials for AC0010 in patients with advanced ...
Breaking Biology Technology:
Cached News: