Gene defects tied to inability of cells to repair DNA damage

In new research carrying implications for human disease development, University of North Carolina scientists and others have linked gene defects to the inability of cells to repair damaged DNA.

The findings published April 13 in the journal Cell offer new insights into how cells repair the DNA damage that may occur during normal metabolism. Such naturally occurring oxidative damage promotes tissue changes thought to be associated with disease development, including cancer, heart disease and rheumatoid arthritis.

Study co-author Steven A. Leadon, Ph.D., head of molecular radiobiology at the UNC Lineberger Comprehensive Cancer Center said "oxidative damage is probably the most common type of damage humans are exposed to because we live and breath oxygen, and oxygen can be reactive and cause DNA damage." Within cells, oxidation leads to formation of free radicals, short-lived highly active particles that occur naturally during metabolism. These are also introduced into the body through smoking, inhaling environmental pollutants, or exposure to the sun's ultraviolet (UV) radiation. From numerous studies, free radicals are known to interact readily with nearby molecules to cause cellular damage, including damage to genetic material.

Damage repair to an active gene, one that continually produces proteins crucial to cellular function, normally occurs through a process known as transcription coupled repair. "We were trying to understand how defects in one of the proteins required for this process works," Leadon said. "And what we were looking at was whether or not the defect has something to do with the inability to repair oxidative damage that occurs in a gene."

In 1998, Leadon and his UNC colleagues were the first to link the defective breast cancer gene BRCA1 to the inability of cells to correct DNA oxidative damage. His work directly demonstrated that BRCA1 was required for transcription-coupled repair. Those studies involved altered cells derived fro

Contact: Leslie H. Lang
University of North Carolina School of Medicine

Page: 1 2 3

Related biology news :

1. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
2. Gene defects found in age-related macular degeneration
3. Antioxidants during pregnancy may help prevent birth defects tied to alcohol
4. LARGE protein can overcome defects in some types of muscular dystrophy
5. Cardiofunk mutation: Probable source of congenital heart defects
6. Fat cells heal skull defects in mice, Stanford research shows
7. Missing gene a potential risk factor for birth defects
8. Cystic fibrosis gene linked to fatty acid defects
9. Researchers show absence of key oxygen-sensing molecule leads to developmental defects
10. Researchers identify second gene responsible for rare syndrome associated with skeletal defects
11. Stem cell defects are key to Hirschsprungs disease

Post Your Comments:

(Date:5/9/2016)... , UAE, May 9, 2016 ... it comes to expanding freedom for high net worth ... Even in today,s globally connected world, there is still ... system could ever duplicate sealing your deal with a ... second passports by taking advantage of citizenship via investment ...
(Date:4/26/2016)... India and LONDON ... Infosys Finacle, part of EdgeVerve Systems, a product ... and Onegini today announced a partnership to integrate ... solutions.      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ... to provide their customers enhanced security to access ...
(Date:4/15/2016)... 2016 Research and Markets has ... Market 2016-2020,"  report to their offering.  , ... ,The global gait biometrics market is expected to ... period 2016-2020. Gait analysis generates multiple ... used to compute factors that are not or ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 2016  Liquid Biotech USA ... a Sponsored Research Agreement with The University of ... from cancer patients.  The funding will be used ... with clinical outcomes in cancer patients undergoing a ... be employed to support the design of a ...
(Date:6/24/2016)... 2016 Epic Sciences unveiled a liquid ... to PARP inhibitors by targeting homologous recombination deficiency ... new test has already been incorporated into numerous ... types. Over 230 clinical trials are ... including PARP, ATM, ATR, DNA-PK and WEE-1. Drugs ...
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, a ... eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced clinical research ... by providing practical tips, tools, and strategies for clinical researchers. , “The landscape ...
(Date:6/23/2016)... 23, 2016 /PRNewswire/ - FACIT has announced the ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or ... of a portfolio of first-in-class WDR5 inhibitors for ... as WDR5 represent an exciting class of therapies, ... medicine for cancer patients. Substantial advances have been ...
Breaking Biology Technology:
Cached News: