HOME >> BIOLOGY >> NEWS
Gene defects tied to inability of cells to repair DNA damage

In new research carrying implications for human disease development, University of North Carolina scientists and others have linked gene defects to the inability of cells to repair damaged DNA.

The findings published April 13 in the journal Cell offer new insights into how cells repair the DNA damage that may occur during normal metabolism. Such naturally occurring oxidative damage promotes tissue changes thought to be associated with disease development, including cancer, heart disease and rheumatoid arthritis.

Study co-author Steven A. Leadon, Ph.D., head of molecular radiobiology at the UNC Lineberger Comprehensive Cancer Center said "oxidative damage is probably the most common type of damage humans are exposed to because we live and breath oxygen, and oxygen can be reactive and cause DNA damage." Within cells, oxidation leads to formation of free radicals, short-lived highly active particles that occur naturally during metabolism. These are also introduced into the body through smoking, inhaling environmental pollutants, or exposure to the sun's ultraviolet (UV) radiation. From numerous studies, free radicals are known to interact readily with nearby molecules to cause cellular damage, including damage to genetic material.

Damage repair to an active gene, one that continually produces proteins crucial to cellular function, normally occurs through a process known as transcription coupled repair. "We were trying to understand how defects in one of the proteins required for this process works," Leadon said. "And what we were looking at was whether or not the defect has something to do with the inability to repair oxidative damage that occurs in a gene."

In 1998, Leadon and his UNC colleagues were the first to link the defective breast cancer gene BRCA1 to the inability of cells to correct DNA oxidative damage. His work directly demonstrated that BRCA1 was required for transcription-coupled repair. Those studies involved altered cells derived fro
'"/>

Contact: Leslie H. Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
13-Apr-2000


Page: 1 2 3

Related biology news :

1. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
2. Gene defects found in age-related macular degeneration
3. Antioxidants during pregnancy may help prevent birth defects tied to alcohol
4. LARGE protein can overcome defects in some types of muscular dystrophy
5. Cardiofunk mutation: Probable source of congenital heart defects
6. Fat cells heal skull defects in mice, Stanford research shows
7. Missing gene a potential risk factor for birth defects
8. Cystic fibrosis gene linked to fatty acid defects
9. Researchers show absence of key oxygen-sensing molecule leads to developmental defects
10. Researchers identify second gene responsible for rare syndrome associated with skeletal defects
11. Stem cell defects are key to Hirschsprungs disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/20/2016)... , May 20, 2016  VoiceIt is excited ... with VoicePass. By working together, VoiceIt ...  Because VoiceIt and VoicePass take slightly different approaches ... increases both security and usability. ... about this new partnership. "This marketing ...
(Date:5/12/2016)... 2016 WearablesResearch.com , a brand of ... results from the Q1 wave of its quarterly wearables ... consumers, receptivity to a program where they would receive ... insurance company. "We were surprised to see ... Michael LaColla , CEO of Troubadour Research, "primarily because ...
(Date:5/3/2016)... May 3, 2016  Neurotechnology, a provider of ... MegaMatcher Automated Biometric Identification System (ABIS) , a ... projects. MegaMatcher ABIS can process multiple complex biometric ... combination of fingerprint, face or iris biometrics. It ... and MegaMatcher Accelerator , which have ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... ... and Mold) microbial test has received AOAC Research Institute approval 061601. , “This ... introduced last year,” stated Bob Salter, Vice President of Regulatory and Industrial Affairs. ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the Industry ... Supplyframe Design Lab . Located in Pasadena, Calif., the Design Lab’s mission ... hardware projects are designed, built and brought to market. , The Design Lab ...
(Date:6/23/2016)... NEWPORT BEACH, Calif. , June 23, 2016 /PRNewswire/ ... offering new biological discoveries to the medical community, has ... and co-founder Matthew Nunez . "We ... provide us with the capital we need to meet ... funding will essentially provide us the runway to complete ...
(Date:6/23/2016)... ... June 23, 2016 , ... Regulatory Compliance ... consulting, provides a free webinar on Performing Quality Investigations: Getting to ... 12pm CT at no charge. , Incomplete investigations are still a major concern ...
Breaking Biology Technology:
Cached News: