HOME >> BIOLOGY >> NEWS
Gene expression in liver tumors and patient prognosis

tures. They also had higher expression of genes involved in ubiquitination and histone modification, which suggests an involvement of these processes in aggressive HCC.

"Our results indicate that HCC prognosis can be readily predicted from the gene expression profiles of primary tumors," the authors report. Furthermore, they suggest that the unique molecular characteristics of each subclass could be useful in developing new therapies for liver cancer patients.

"Even if a curative therapy for HCC patients cannot be offered at this stage, it may be possible to identify therapeutic targets that can slow the course of disease progression," the authors conclude. "For example, small molecules that inhibit activities of some transcription factors are already available and may provide opportunities to alter the course of HCC progression in both subclass A and B."

An accompanying editorial by Joseph Locker, M.D. of Albert Einstein College of Medicine in New York, underscores the conclusions of the study by Lee et al. and points out that their work has produced an extremely large data set that is a valuable resource for many kinds of studies.

"Lee et al. focused on unsupervised clustering and prognosis, but there are numerous other important questions that could be approached with further analysis of their comprehensive data sets," writes Locker. "Most important, expression profiling will reveal specific targets for rational therapy."


'"/>

Contact: David Greenberg
dgreenbe@wiley.com
201-748-6484
John Wiley & Sons, Inc.
13-Sep-2004


Page: 1 2

Related biology news :

1. A novel, safer strategy for regulating gene expression
2. Analysis of gene expression in lymphoid cells can determine lymphoma cancer
3. Jefferson scientists find gene expression pattern may predict behavior of leukemia
4. Outcome for acute lymphoblastic leukemia linked to gene expression patterns
5. Microarrays, key genome expression trackers, work better when probes are sequence-verified
6. Gene expression patterns may help predict risk and progression of prostate cancer
7. Altered expression of key developmental genes underlies evolution of butterfly wing patterns
8. New technique images gene expression in mice
9. Sex-specific differences in gene expression related to drug metabolism and hypertension
10. Gene expression ratio identifies risk of recurrence in breast cancer patients receiving tamoxifen
11. Gene expression profiling may predict head, neck cancer recurrence

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/25/2020)... OXFORD, United Kingdom (PRWEB) , ... May 22, 2020 , ... ... test (assay) for the detection of SARS-CoV-2, the virus that causes COVID-19. ... cater to on-demand analysis of smaller sample numbers, to very large numbers of samples. ...
(Date:5/21/2020)... (PRWEB) , ... May 19, ... ... the leading software-as-a-service (SaaS) provider of operations management solutions, today introduced BioMed ... module provides a cloud-based platform for connecting the people and systems around ...
(Date:5/21/2020)... ... May 20, 2020 , ... Law Enforcement has always been ... all of us. The positions of these men and women put them constantly in ... not following rules precisely. Officers have always had to face very high daily stress. ...
Breaking Biology News(10 mins):
(Date:5/5/2020)... PARIS (PRWEB) , ... May 05, 2020 , ... ... appointing a high-profile CEO. Xavier Duburcq joins the group after 13 years at Altran, ... Chemicals. , Holding a PhD in Immunology and being a Pharmacist, Xavier was involved ...
(Date:4/22/2020)... BUDAPEST, Hungary and CAMBRIDGE, Mass. (PRWEB) , ... ... ... headquartered in Budapest with US offices in Cambridge, MA, announced today that Omixon’s ... Meintjes led the early commercialisation of Omixon’s flagship product Holotype HLA since 2014 ...
(Date:4/7/2020)... ... April 06, 2020 , ... Red Nucleus, a ... industry, has announced the release of at-home virtual learning resources for all client ... health and safety of our employees as we continue to implement measures to ...
(Date:4/1/2020)... ... March 31, 2020 , ... Bedoukian Research, ... of a Joint Development Agreement that builds on each company’s expertise in developing ... leader in the supply of high-quality insect pheromones as well as flavors and ...
Breaking Biology Technology:
Cached News: