Gene expression profiling may predict head, neck cancer recurrence

CHAPEL HILL -- Results from a new study of tumor genetics may give doctors valuable information in deciding how aggressively to treat patients with head and neck cancer. Head and neck tumors account for more than 40,000 new cancers annually in the United States. The most common of these is squamous cell carcinoma. Prognosis is based largely on location and size of the tumor, and if the cancer has spread, or metastasized, to lymph nodes and distant sites in the body.

The study identified four tumor gene expression patterns that may serve as biomarkers of prognosis, including tumor recurrence or metastasis, for patients with head and neck squamous cell cancer and for whom aggressive therapy might be best.

Dr. Charles M. Perou, assistant professor of genetics and pathology and laboratory medicine at the University of North Carolina at Chapel Hill School of Medicine, led the study.

Writing in the May 18 issue of the journal Cancer Cell, Perou, also a member of the UNC Lineberger Comprehensive Cancer Center, and colleagues from UNC and Vanderbilt University presented their findings based on the gene expression patterns of 60 head and neck tumor samples that were assayed using DNA microarrays, a technology Perou pioneered. The samples came from patients at UNC Hospitals.

"This technology allows us to determine the expression level of tens of thousands of genes at once," Perou said. "What excites me about gene expression profiling is that it allows us to study real human tumor samples and collect thousands of data points which we could not do before. There is no animal model system here. We're studying the disease as people have it."

Gene expression refers to the transcription of the information contained within DNA, the repository of genetic information, into messenger RNA (mRNA) molecules that are then translated into the proteins that perform most of the cells' critical functions.

Scientists then study the kinds and amount

Contact: Leslie H. Lang
University of North Carolina School of Medicine

Page: 1 2 3

Related biology news :

1. A novel, safer strategy for regulating gene expression
2. Gene expression in liver tumors and patient prognosis
3. Analysis of gene expression in lymphoid cells can determine lymphoma cancer
4. Jefferson scientists find gene expression pattern may predict behavior of leukemia
5. Outcome for acute lymphoblastic leukemia linked to gene expression patterns
6. Microarrays, key genome expression trackers, work better when probes are sequence-verified
7. Gene expression patterns may help predict risk and progression of prostate cancer
8. Altered expression of key developmental genes underlies evolution of butterfly wing patterns
9. New technique images gene expression in mice
10. Sex-specific differences in gene expression related to drug metabolism and hypertension
11. Gene expression ratio identifies risk of recurrence in breast cancer patients receiving tamoxifen

Post Your Comments:

(Date:5/23/2017)... robotic gym for the rehabilitation and functional motor sense evaluation of lower ... . The first 30 robots will be available from June in ... The technology was developed and patented at the IIT laboratories and has ... to a 10 million euro investment from entrepreneur Sergio Dompè. ... ...
(Date:4/24/2017)... 24, 2017 Janice Kephart , ... Identity Strategy Partners, LLP (IdSP) , today issues ... President Trump,s March 6, 2017 Executive Order: ... vetting can be instilled with greater confidence, enabling ... all refugee applications are suspended by until at ...
(Date:4/13/2017)... MONICA, Calif. , April 13, 2017 ... New York will feature emerging and evolving ... Summits. Both Innovation Summits will run alongside the expo ... of speaker sessions, panels and demonstrations focused on trending ... coast,s largest advanced design and manufacturing event will take ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... , ... Dr. Bob Harman, founder and CEO of VetStem Biopharma, Inc. ... The event entitled “Stem Cells and Their Regenerative Powers,” was held on August ... MPVM was joined by two human doctors: Peter B. Hanson, M.D., Chief of Orthopedic ...
(Date:10/10/2017)... , Oct. 10, 2017 SomaGenics announced the ... NIH to develop RealSeq®-SC (Single Cell), expected to be ... small RNAs (including microRNAs) from single cells using NGS ... the need to accelerate development of approaches to analyze ... "New techniques for measuring levels of mRNAs ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... 13 prestigious awards honoring scientists who have made outstanding contributions ... scheduled symposium during Pittcon 2018, the world’s leading conference and exposition for laboratory ...
(Date:10/9/2017)... ... ... The award-winning American Farmer television series will feature 3 Bar Biologics in ... 8:30aET on RFD-TV. , With global population estimates nearing ten billion people by ... feed a growing nation. At the same time, many of our valuable resources are ...
Breaking Biology Technology:
Cached News: