HOME >> BIOLOGY >> NEWS
Gene linked to cleft lip and palate identified

WHITE PLAINS, AUGUST 19, 2004 -- An international team of researchers has identified a gene variant that is a major contributor to oral clefts and triples the risk of recurrence in affected families, it was reported today in The New England Journal of Medicine.

"Cleft lip and cleft palate are among the most common birth defects in the United States," says Nancy S. Green, M.D., medical director of the March of Dimes, which helped fund the study. "This new finding brings us closer to understanding the multiple genetic factors underlying these very serious birth defects, with probable environmental effects."

The discovery also has important implications for genetic counseling for families who have had one or more children with an isolated cleft lip and/or cleft palate (not associated with any syndrome or other malformation), Dr. Green says.

"A special strength of this study is that its findings come from a variety of ethnic groups, including Europeans, South Americans, and Asians," Dr. Green says. "This gives us confidence that the linkage of this gene variant to oral clefts is true across different populations in the U.S. and worldwide."

The March of Dimes provided funding to Eduardo E. Castilla, M.D., Ph.D., Professor at ECLAMC, a genetic resource facility in Brazil, as well as to a collaboration between Andrew Lidral, D.D.S., Ph.D., Associate Professor, Department of Orthodontics, University of Iowa, Iowa City, and Mauricio Arcos-Burgos, M.D., Ph.D., at the University of Antioquia, Medellin, Colombia.

Cleft lip (with and without cleft palate) occurs in about 1 in every 1,000 births in the U.S., or more than 4,000 babies each year. A cleft is an opening or separation in a body structure. Clefts that occur in the oral-facial region often involve the upper lip, the roof of the mouth (hard palate), or the soft tissue in the back of the mouth (soft palate). More than 70 percent of babies with cleft lip also have cleft
'"/>

Contact: Michele Kling
mkling@marchofdimes.com
914-997-4613
March of Dimes Birth Defects Foundation
18-Aug-2004


Page: 1 2

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival
3. Protein involved in childhood disorder linked to cancer
4. Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis
5. Schizophrenia gene variant linked to risk traits
6. Gene changes linked to increased eye pressure may have implications for glaucoma therapy
7. Excess levels of nitrogen, phosphorus linked to deformed frogs
8. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
9. LBP-1a gene mutation linked to disruption of normal fetal development
10. Outcome for acute lymphoblastic leukemia linked to gene expression patterns
11. UCI study reveals gene linked to breast cancer can suppress tumors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/7/2016)... India , December 7, 2016 According to a ... Machine Learning), Software Tool (Facial Expression, Voice Recognition), Service, Application Area, End User, ... is estimated to grow from USD 6.72 Billion in 2016 to USD 36.07 ... Continue Reading ... ...
(Date:12/7/2016)...   Veridium , a leader in biometrics-based ... CEO James Stickland . Stickland, a seasoned ... has served in senior executive roles for HSBC, ... expanding a pipeline of venture capital and accelerating ... served as managing director of U.K.-based fintech firm ...
(Date:12/6/2016)... , Dec. 6, 2016 Securus Technologies, ... technology solutions for public safety, investigation, corrections and ... announced today a five (5) year funding commitment ... to expand the rehabilitation and reentry support to ... History Established in 2004, the Prison Entrepreneurship Program ...
Breaking Biology News(10 mins):
(Date:1/12/2017)... Linda, Ca (PRWEB) , ... ... ... for low-cost, disposable devices with short response times capable of performing routine ... food fields, disposable screen-printed electrodes provide fast, sensitive detection and quantification of ...
(Date:1/12/2017)... ... January 12, 2017 , ... After her ... Rosendahl’s doctors gave her only a few months to live. Now a paper ... has stabilized Rosendahl’s disease and increased both the quantity and quality of her ...
(Date:1/12/2017)... 2017   Protein Sciences Corporation , a ... Flublok Influenza Vaccine ®, announced today that its ... safety results and induced strong neutralizing antibodies against ... is expected to advance into human clinical trials ... Institute of Technology in Immunobiologicals of the Oswaldo ...
(Date:1/12/2017)... The report "Direct-Fed Microbials Market by Type (Lactic Acid Bacteria and Bacillus), Livestock (Pork/Swine, ... Forecast to 2022", published by MarketsandMarkets, the global market is estimated to be ... Million by 2022, at a CAGR of 6.96% from 2016. ... ... Logo ...
Breaking Biology Technology:
Cached News: