HOME >> BIOLOGY >> NEWS
Gene linked to cleft lip and palate identified

WHITE PLAINS, AUGUST 19, 2004 -- An international team of researchers has identified a gene variant that is a major contributor to oral clefts and triples the risk of recurrence in affected families, it was reported today in The New England Journal of Medicine.

"Cleft lip and cleft palate are among the most common birth defects in the United States," says Nancy S. Green, M.D., medical director of the March of Dimes, which helped fund the study. "This new finding brings us closer to understanding the multiple genetic factors underlying these very serious birth defects, with probable environmental effects."

The discovery also has important implications for genetic counseling for families who have had one or more children with an isolated cleft lip and/or cleft palate (not associated with any syndrome or other malformation), Dr. Green says.

"A special strength of this study is that its findings come from a variety of ethnic groups, including Europeans, South Americans, and Asians," Dr. Green says. "This gives us confidence that the linkage of this gene variant to oral clefts is true across different populations in the U.S. and worldwide."

The March of Dimes provided funding to Eduardo E. Castilla, M.D., Ph.D., Professor at ECLAMC, a genetic resource facility in Brazil, as well as to a collaboration between Andrew Lidral, D.D.S., Ph.D., Associate Professor, Department of Orthodontics, University of Iowa, Iowa City, and Mauricio Arcos-Burgos, M.D., Ph.D., at the University of Antioquia, Medellin, Colombia.

Cleft lip (with and without cleft palate) occurs in about 1 in every 1,000 births in the U.S., or more than 4,000 babies each year. A cleft is an opening or separation in a body structure. Clefts that occur in the oral-facial region often involve the upper lip, the roof of the mouth (hard palate), or the soft tissue in the back of the mouth (soft palate). More than 70 percent of babies with cleft lip also have cleft
'"/>

Contact: Michele Kling
mkling@marchofdimes.com
914-997-4613
March of Dimes Birth Defects Foundation
18-Aug-2004


Page: 1 2

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival
3. Protein involved in childhood disorder linked to cancer
4. Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis
5. Schizophrenia gene variant linked to risk traits
6. Gene changes linked to increased eye pressure may have implications for glaucoma therapy
7. Excess levels of nitrogen, phosphorus linked to deformed frogs
8. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
9. LBP-1a gene mutation linked to disruption of normal fetal development
10. Outcome for acute lymphoblastic leukemia linked to gene expression patterns
11. UCI study reveals gene linked to breast cancer can suppress tumors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/16/2016)... The global Biometric ... USD 1.83 billion by 2024, according to a ... proliferation and increasing demand in commercial buildings, consumer ... the market growth.      (Logo: ... of advanced multimodal techniques for biometric authentication and ...
(Date:6/9/2016)... innovation leader in attendance control systems is proud to announce the introduction of fingerprint ... sure the right employees are actually signing in, and to even control the opening ... ... ... Photo ...
(Date:6/7/2016)... 2016  Syngrafii Inc. and San Antonio Credit ... includes integrating Syngrafii,s patented LongPen™ eSignature "Wet" solution ... will result in greater convenience for SACU members ... maintaining existing document workflow and compliance requirements. ... Highlights: ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Md. , June 23, 2016 A person ... from the crime scene to track the criminal down. ... the U.S. Food and Drug Administration (FDA) uses DNA evidence ... Sound far-fetched? It,s not. The FDA ... sequencing to support investigations of foodborne illnesses. Put as simply ...
(Date:6/23/2016)... , June, 23, 2016  The Biodesign Challenge (BDC), ... new ways to harness living systems and biotechnology, announced ... (MoMA) in New York City . ... participating students, showcased projects at MoMA,s Celeste Bartos Theater ... Antonelli , MoMA,s senior curator of architecture and design, ...
(Date:6/23/2016)... NC (PRWEB) , ... June 23, 2016 , ... In ... University Hospital in Denmark detail how a patient who developed lymphedema after being treated ... tissue. The results could change the paradigm for dealing with this debilitating, frequent side ...
(Date:6/23/2016)... 2016 On Wednesday, June 22, 2016, ... 0.22%; the Dow Jones Industrial Average edged 0.27% lower to ... down 0.17%. Stock-Callers.com has initiated coverage on the following equities: ... (NASDAQ: NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ... BIND ). Learn more about these stocks by accessing their ...
Breaking Biology Technology:
Cached News: