HOME >> BIOLOGY >> NEWS
Gene linked to cleft lip and palate identified

WHITE PLAINS, AUGUST 19, 2004 -- An international team of researchers has identified a gene variant that is a major contributor to oral clefts and triples the risk of recurrence in affected families, it was reported today in The New England Journal of Medicine.

"Cleft lip and cleft palate are among the most common birth defects in the United States," says Nancy S. Green, M.D., medical director of the March of Dimes, which helped fund the study. "This new finding brings us closer to understanding the multiple genetic factors underlying these very serious birth defects, with probable environmental effects."

The discovery also has important implications for genetic counseling for families who have had one or more children with an isolated cleft lip and/or cleft palate (not associated with any syndrome or other malformation), Dr. Green says.

"A special strength of this study is that its findings come from a variety of ethnic groups, including Europeans, South Americans, and Asians," Dr. Green says. "This gives us confidence that the linkage of this gene variant to oral clefts is true across different populations in the U.S. and worldwide."

The March of Dimes provided funding to Eduardo E. Castilla, M.D., Ph.D., Professor at ECLAMC, a genetic resource facility in Brazil, as well as to a collaboration between Andrew Lidral, D.D.S., Ph.D., Associate Professor, Department of Orthodontics, University of Iowa, Iowa City, and Mauricio Arcos-Burgos, M.D., Ph.D., at the University of Antioquia, Medellin, Colombia.

Cleft lip (with and without cleft palate) occurs in about 1 in every 1,000 births in the U.S., or more than 4,000 babies each year. A cleft is an opening or separation in a body structure. Clefts that occur in the oral-facial region often involve the upper lip, the roof of the mouth (hard palate), or the soft tissue in the back of the mouth (soft palate). More than 70 percent of babies with cleft lip also have cleft
'"/>

Contact: Michele Kling
mkling@marchofdimes.com
914-997-4613
March of Dimes Birth Defects Foundation
18-Aug-2004


Page: 1 2

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival
3. Protein involved in childhood disorder linked to cancer
4. Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis
5. Schizophrenia gene variant linked to risk traits
6. Gene changes linked to increased eye pressure may have implications for glaucoma therapy
7. Excess levels of nitrogen, phosphorus linked to deformed frogs
8. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
9. LBP-1a gene mutation linked to disruption of normal fetal development
10. Outcome for acute lymphoblastic leukemia linked to gene expression patterns
11. UCI study reveals gene linked to breast cancer can suppress tumors

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene linked cleft lip and palate identified

(Date:7/8/2015)... DIEGO , July 8, 2015  Trovagene, ... cell-free molecular diagnostics, today announced the launch of ... the Company,s Precision Cancer Monitoring℠ (PCM) technology for ... receiving one or a combination of the novel ... Opdivo® (nivolumab), a PD-1 inhibitor. The 50-patient study ...
(Date:7/7/2015)... -- Research and Markets ( ... "Capacitive Fingerprint Sensors Patent Landscape" report ... fingerprint sensing technology is the most reliable and ... developed. This patent landscape focuses on fingerprint sensors ... of capacitive fingerprint sensors is closely linked to ...
(Date:7/7/2015)... July 7, 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... growing mobile commerce market announces a revised version of one of ... commercial will air on CNBC in New York ... and San Francisco metro areas.    ... on Wocket,s ability to replace all the cards in your wallet ...
Breaking Biology News(10 mins):Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 2Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 3Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 4Worldwide Capacitive Fingerprint Sensors Patent Landscape Market Report 2015-2020 - Main IP Holders include Seiko Epson, AuthenTec, Sony and STMicroelectronics 2Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 2Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 3
(Date:7/27/2015)... ... July 27, 2015 , ... Brady ... new video: 3 Ways to GHS Labels . This video provides useful ... Harmonized System (GHS) by effectively labeling chemical containers. , “With the fourth and ...
(Date:7/27/2015)... -- According to the new Market Research Report ... by Application (Biobanking, Regenerative Medicine, Drug Discovery), by Geography ( ... Asia-Pacific , Rest of the World) - ... was valued at $247.7 million in 2014, which is estimated ... CAGR of 18.2% between 2014 and 2019. Browse ...
(Date:7/27/2015)... (PRWEB) , ... July 27, 2015 , ... Visual Assay ... and celebrate the top 100 most innovative technologies and services of the past year. ... named in the Software/Services category. The winners will be announced at the 2015 R&D ...
(Date:7/24/2015)... (PRWEB) , ... July 24, 2015 , ... VetStem Biopharma, ... Center in support of stem cell therapy training and clinical opportunities. , “We are ... opportunity to veterinarians in the San Diego area. Stem cell therapy is an established ...
Breaking Biology Technology:Brady Releases “3 Roads to GHS Labels” Video 2Global Biopreservation Media Market to be Worth $571.5 Million by 2019 2Global Biopreservation Media Market to be Worth $571.5 Million by 2019 3Visual Assay® Named Finalist in 53rd Annual R&D 100 Awards 2VetStem Biopharma, proudly announces a new long term partnership with VCA Emergency Animal Hospital & Referral Center. 2VetStem Biopharma, proudly announces a new long term partnership with VCA Emergency Animal Hospital & Referral Center. 3
Cached News: